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26

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1779	SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM)，具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性，可以活化 Hedgehog 信号通路。
T35559	SAG 21k	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG 21k 是一种可透过血脑屏障且具有口服生物活性和有效性的 Hedgehog 信号激活剂，可用于研究软骨再生。
T40465	SAG dihydrochloride	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG dihydrochloride 是一种强效的 Smoothened（Smo）受体激动剂（EC 50 =3 nM；K d =59 nM）。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。
T4211	SAG hydrochloride (912545-86-9(free base)) Smoothened Agonist HCl	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。
T24754	Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。
T20845	Kopexil Mexoryl SAG,Aminexil
	Kopexil, an N-oxide, is used to treat hair loss.
T24159	IHR-1 IHR 1	Smo	Stem Cells
	IHR-1 是一种Smo 拮抗剂，不能透过细胞膜。
T23027	MRT-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂，通过多种 Hedgehog (Hh) 测定，其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。
T17044	Tesaglitazar	PPAR	DNA Damage/DNA Repair; Metabolism
	Tesaglitazar 是一种有效且具有选择性的过氧化物 PPAR α / γ受体双重激动剂，对 PPARγ的亲和力比 PPARα更有效，对大鼠PPARα和人PPARα的EC50分别为13.4 μM 和3.6 μM,对大鼠PPARγ和人类 PPARγ的EC50都是0.2 μM。Tesaglitazar 诱导大鼠皮下组织间质间充质细胞DNA 合成和纤维肉瘤形成。
T6962	Rasagiline Mesylate TVP1012,甲磺酸雷沙吉兰,AGN1135,Azilect	Apoptosis; MAO; Autophagy; Monoamine Oxidase	Apoptosis; Autophagy; Metabolism; Neuroscience
	Rasagiline Mesylate (AGN1135) 是一种高效的，不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的IC50分别为 4.43 nM 和 412 nM。
T1119	Rasagiline 雷沙吉兰,AGN1135,TVP1012	BCL; MAO; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience
	Rasagiline (AGN1135) 是不可逆的、高效的、选择性的线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC50分别为 4.43 nM 和 412 nM。
T80981	Tisagenlecleucel CTL019
	Tisagenlecleucel (CTL019) 是一种自体抗CD19嵌合抗原受体 (CAR) T 细胞治疗，专门针对并消除表达CD19的 B 细胞。该疗法主要用于研究治疗难治性侵袭性弥漫性大 B 细胞淋巴瘤。
T13252L	(S)-Rasagiline mesylate TVP1022 (mesylate),(S)-雷沙吉兰甲磺酸,S-PAI mesylate	Others	Others
	(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson.
T16273	Napsagatran hydrate Ro 46-6240/010 hydrate,Ro 46-6240 hydrate	Others	Others
	Napsagatran hydrate is a novel and specific inhibitor of thrombin.
T8683	Mipsagargin G-202	Others	Others
	Mipsagargin (G-202) 是一种抑制 DNA 生物合成的新型抗生素。
T82346	Galanin message associated peptide (1-41) amide
	Galanin message-associated peptide (1-41) amide 是肽类激素，结构由41个氨基酸残基组成，并以酰胺形式存在。
T12693	Rasagiline 13C3 mesylate racemic TVP1012 13C3 racemic,AGN1135 13C3 racemic	Others	Others
	Rasagiline 13C3 mesylate racemic is the deuterium labeled Rasagiline, which is an irreversible monoamine oxidase inhibitor.
T13252	(S)-Rasagiline TVP1022,(S)-雷沙吉兰,S-PAI	Others	Others
	(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson.
T71910	Racemic rasagiline
	Racemic rasagiline，也称为 AGN-1135，是一种单胺氧化酶 B 型抑制剂(MAOI)。然而，在食用富含酪胺的食物的患者中，这种药物的应用可能导致致命的高血压危象。TVP-1022是雷沙吉兰的(S)异构体，具有心脏保护剂的作用。
T124794	Kokusaginine
	Kokusaginine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124794。
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...
T69480	Sagopilone
	Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites wa...
T28995	Tosagestin Org 30659,Org30659,Org-30659
	Tosagestin is a progesterone receptor agonist.
T22089	HPI 1	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活（Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM） .
T11070L	DO34	Others	Others
	DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG).
T35562	Nat-20(S)-yne
	Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, whi...

化合物

Cat.No: T1779

Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist

Target: Hedgehog/Smoothened, Smo

Cat.No: T35559

Target: Hedgehog/Smoothened

SAG dihydrochloride

Cat.No: T40465

Target: Hedgehog/Smoothened

SAG hydrochloride (912545-86-9(free base))

Cat.No: T4211

Synonym: Smoothened Agonist HCl

Target: Hedgehog/Smoothened

Cat.No: T24754

Synonym: SAG-1.5,SAG1.5,SAG 1.5

Target: Hedgehog/Smoothened

Cat.No: T20845

Synonym: Mexoryl SAG,Aminexil

Cat.No: T24159

Synonym: IHR 1

Target: Smo

Cat.No: T23027

Target: Hedgehog/Smoothened

Cat.No: T17044

Target: PPAR

Rasagiline Mesylate

Cat.No: T6962

Synonym: TVP1012,甲磺酸雷沙吉兰,AGN1135,Azilect

Target: Apoptosis, MAO, Autophagy, Monoamine Oxidase

Cat.No: T1119

Synonym: 雷沙吉兰,AGN1135,TVP1012

Target: BCL, MAO, Monoamine Oxidase

Tisagenlecleucel

Cat.No: T80981

Synonym: CTL019

(S)-Rasagiline mesylate

Cat.No: T13252L

Synonym: TVP1022 (mesylate),(S)-雷沙吉兰甲磺酸,S-PAI mesylate

Target: Others

Napsagatran hydrate

Cat.No: T16273

Synonym: Ro 46-6240/010 hydrate,Ro 46-6240 hydrate

Target: Others

Cat.No: T8683

Synonym: G-202

Target: Others

Galanin message associated peptide (1-41) amide

Cat.No: T82346

Rasagiline 13C3 mesylate racemic

Cat.No: T12693

Synonym: TVP1012 13C3 racemic,AGN1135 13C3 racemic

Target: Others

Cat.No: T13252

Synonym: TVP1022,(S)-雷沙吉兰,S-PAI

Target: Others

Racemic rasagiline

Cat.No: T71910

Cat.No: T124794

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

Cat.No: T69480

Cat.No: T28995

Synonym: Org 30659,Org30659,Org-30659

Cat.No: T22089

Target: Hedgehog/Smoothened

Cat.No: T11070L

Target: Others

Cat.No: T35562

Cat. No.	Product Name	Target	Signaling Pathways
T81482	Physagulide J
	Physagulide J, 一种睡茄内酯类化合物，可从苦蘵 (Physalis angulata L.) 分离。此化合物与苦蘵的其他活性成分共同展现抗炎及抗肿瘤活性。
TQ0163	Sagittatoside A Icariin-A,箭藿苷 A	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
TQ0168	Sagittatoside B	Others	Others
	Sagittatoside B is a natural product from Epimedium brevicornu Maxim.
TN4932	Sageone	PARP; Akt; Caspase; Antifection	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
TN2168	Sagittatoside C 箭藿苷 C,箭藿苷C	Others	Others
	Sagittatoside C is a natural product
TN4259	Iso-sagittatoside A	Others	Others
	Iso-sagittatoside A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4259，CAS号为 503456-08-4。

天然产物

Cat.No: T81482

Sagittatoside A

Cat.No: TQ0163

Synonym: Icariin-A,箭藿苷 A

Target: Estrogen/progestogen Receptor

Sagittatoside B

Cat.No: TQ0168

Target: Others

Cat.No: TN4932

Target: PARP, Akt, Caspase, Antifection

Sagittatoside C

Cat.No: TN2168

Synonym: 箭藿苷 C,箭藿苷C

Target: Others

Iso-sagittatoside A

Cat.No: TN4259

Target: Others

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