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Search Results for " p-selectin "

Targets Recommended: Others

15

抑制剂 & 化合物

2

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22889	KF38789 KF 38789	Others	Others
	KF38789 特异性的抑制P-selectin 与PSGL-1结合。它对 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 的结合具有抑制作用 (IC50:1.97 μM) 。
T16676	PSI-697 P-Selectin Inhibitor	Others	Others
	PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).
T78288	Inclacumab Anti-Human selectin P Recombinant Antibody
	Inclacumab（Anti-HumanselectinP Recombinant Antibody）是一种人源化IgG4单克隆抗体，专一性靶向P-selectin，Kd为9.9 nM。该抗体能够抑制P-selectin糖蛋白配体1（PSGL-1）模拟肽与P-selectin的结合，其IC50为1.9 µg/mL，且显著抑制细胞粘附。
T1893	Parmodulin 2 ML 161	Protease-activated Receptor	GPCR/G Protein
	Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂，IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂，可以抑制体外血小板聚集和体内血小板血栓形成。
T77399	Crizanlizumab ADAKVEO,SEG-101	Others	Others
	Crizanlizumab（Adakveo）是一种针对 P-选择素的人源化单克隆抗体，用于预防镰状细胞病的疼痛危象。
T14573	Bimosiamose disodium TBC-1269Z	Integrin	Cytoskeletal Signaling
	Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively.
T14574	Bimosiamose TBC-1269	Integrin	Cytoskeletal Signaling
	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
T24144	HMCEF
	HMCEF is a P-selectin inhibitor that acts by intercalating into calf thymus DNA, cutting off DNA pBR22. It also inhibits the proliferation of cancer cells.
T39121	Odatroltide DHDMIQK(KAP),Odatroltide
	Odatroltide is a nanoscale P-selectin inhibitor that serves as a nano-delivery system for 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to specifically target the thrombus.
T25911	Oxycinchophen Magnophenyl,Sintofene,Reumartril,Chinoxone
	Oxycinchophen 是一种喹啉类的有机物，抗风湿病的化合物。它已被用于研究 P- 选择素拮抗活性，DHOD 抑制活性，以及抗炎药对血管平滑肌的作用。
T71472	LN6023
	LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thrombosis.
T35884	Sialyl-Lewis X
	Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2].
T60303	Collagen-IN-1
	Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T35494	(±)11(12)-EET
	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t...

化合物

Cat.No: T22889

Synonym: KF 38789

Target: Others

Cat.No: T16676

Synonym: P-Selectin Inhibitor

Target: Others

Cat.No: T78288

Synonym: Anti-Human selectin P Recombinant Antibody

Cat.No: T1893

Synonym: ML 161

Target: Protease-activated Receptor

Cat.No: T77399

Synonym: ADAKVEO,SEG-101

Target: Others

Bimosiamose disodium

Cat.No: T14573

Synonym: TBC-1269Z

Target: Integrin

Cat.No: T14574

Synonym: TBC-1269

Target: Integrin

Cat.No: T24144

Cat.No: T39121

Synonym: DHDMIQK(KAP),Odatroltide

Cat.No: T25911

Synonym: Magnophenyl,Sintofene,Reumartril,Chinoxone

Cat.No: T71472

Cat.No: T35884

Cat.No: T60303

2-chloro Palmitic Acid

Cat.No: T36221

Cat.No: T35494

Cat. No.	Product Name	Target	Signaling Pathways
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。

天然产物

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02709	P-Selectin Protein, Human, Recombinant (His) GMP140,CD62,CD62P,LECAM3,P-Se...	Human	HEK293 Cells
	P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1.
TMPY-03531	PSGL-1/CD162 Protein, Human, Recombinant (His) selectin P ligand,PSGL-1,P	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1.
TMPY-05013	PSGL-1/CD162 Protein, Human, Recombinant (mFc) PSGL-1,CLA,selectin P ligand,...	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 55.4 kDa and the accession number is AAC50061.1.
TMPY-04708	P-Selectin Protein, Rhesus, Recombinant (hFc) selectin P (granule membrane prot...	Rhesus	HEK293 Cells
	P-Selectin Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 106.8 kDa and the accession number is XP_001094728.1.
TMPY-04101	P-Selectin Protein, Rat, Recombinant (His) selectin P (granule membrane prot...	Rat	HEK293 Cells
	P-Selectin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.4 kDa and the accession number is Q3MID1.
TMPY-02643	P-Selectin Protein, Human, Recombinant (hFc) P-Selectin,CD62P,PSEL,	Human	HEK293 Cells
	P-Selectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107 kDa and the accession number is AAN06828.1.
TMPY-00244	P-Selectin Protein, Rat, Recombinant (hFc) selectin P (granule membrane prot...	Rat	HEK293 Cells
	P-Selectin Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.7 kDa and the accession number is Q3MID1.
TMPY-03415	P-Selectin Protein, Mouse, Recombinant (hFc) LECAM3,PADGEM,Grmp,CD62P,GMP<...	Mouse	HEK293 Cells
	P-Selectin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 99.6 kDa and the accession number is Q01102.
TMPY-03702	P-Selectin Protein, Mouse, Recombinant (His) Grmp,PADGEM,CD62P,LECAM3,sele...	Mouse	HEK293 Cells
	P-Selectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is Q01102.
TMPK-00830	P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated FLJ45155,CD62P,GRMP,CD62,P-Se...	Human	HEK293 Cells
	Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
TMPJ-00382	P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated PADGEM,CD62 antigen-like family member P,G...	Mouse	HEK293 Cells
	P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes...
TMPJ-00257	PSGL-1/CD162 Protein, Human, Recombinant (hFc) Selectin P ligand,P-selectin<...	Human	HEK293 Cells
	PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, ...
TMPY-03354	PSGL-1/CD162 Protein, Mouse, Recombinant Psgl1,Selpl,Psgl-1,Selp1...	Mouse	HEK293 Cells
	PSGL-1/CD162 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 31.2 kDa and the accession number is Q62170.
TMPY-02353	PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) Psgl1,Psgl-1,CD162,selectin P...	Mouse	HEK293 Cells
	PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is Q62170.
TMPY-00906	PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) CLA,selectin P ligand,CD162,PSGL-...	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 57.1 kDa and the accession number is AAC50061.1.
TMPK-00565	PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) PSGL-1,CD162,SELPLG,PSGL1,Sel...	Cynomolgus	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.57 kDa and the accession number is A0A7N9CVJ8.
TMPK-01033	PSGL-1/CD162 Protein, Mouse, Recombinant (His) CLA,SELPLG,Selpl,Selectin P	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.74 kDa and the accession number is Q62170.
TMPJ-00612	PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc) CLA,PSGL1,CD162,PSGL-1	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 ...

重组蛋白

P-Selectin Protein, Human, Recombinant (His)

Cat.No: TMPY-02709

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (His)

Cat.No: TMPY-03531

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05013

Species: Human

Expression System: HEK293 Cells

P-Selectin Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-04708

Species: Rhesus

Expression System: HEK293 Cells

P-Selectin Protein, Rat, Recombinant (His)

Cat.No: TMPY-04101

Species: Rat

Expression System: HEK293 Cells

P-Selectin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02643

Species: Human

Expression System: HEK293 Cells

P-Selectin Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-00244

Species: Rat

Expression System: HEK293 Cells

P-Selectin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03415

Species: Mouse

Expression System: HEK293 Cells

P-Selectin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03702

Species: Mouse

Expression System: HEK293 Cells

P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPK-00830

Species: Human

Expression System: HEK293 Cells

P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00382

Species: Mouse

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00257

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant

Cat.No: TMPY-03354

Species: Mouse

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02353

Species: Mouse

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00906

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00565

Species: Cynomolgus

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01033

Species: Mouse

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)

Cat.No: TMPJ-00612

Species: Mouse

Expression System: HEK293 Cells

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