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Search Results for " p 11 "

63

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7554	Substance P (7-11) Substance P 7-11(TFA)	Others; Neurokinin receptor	GPCR/G Protein; Neuroscience; Others
	Substance P (7-11) (Substance P 7-11(TFA)) 是神经肽物质P 的C-末端片段，可引起细胞内钙浓度的增加。
TP1879L1	P11 acetate	Integrin	Cytoskeletal Signaling
	P11 acetate 是一种整合素 αvβ3-玻连蛋白相互作用拮抗剂 (IC50 = 2.74 nM)。
TP1369L	[Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide（每只大鼠 10-100 pmol，i.c.v.）在增加平均动脉血压 (MAP) 和心率 (HR)，但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻，而它是一种产生美容效果的化合物。
T7828	[Sar9,Met(O2)11]-Substance P Bhsar-sp,NA,精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P (NA) 是选择性速激肽NK1受体激动剂。
T34081	Piromelatine NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂，也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性，对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用，可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。
TP2326L	Oligopeptide P11-4 acetate(593266-60-5 free base)	Others	Others
	Oligopeptide P11-4 acetate(593266-60-5 free base) 是一种肽。
TP1369	[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free) [Sar9,Met(O2)11]-Substance P TFA
	[Sar9,Met(O2)11]-Substance P TFA is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissi
TP2352	Septide Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)
	Septide is an NK1 receptor agonist acting at a site distinct from substance P.
TP1831	[Nle11]-Substance P
	[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons.
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T76455	Substance P (4-11)
	Substance P (4-11) 是 Substance P (Substance P ) 的 C 末端片段，是一种 Substance P 激动剂，对NK1受体具有高度选择性。
T81079	Substance P (2-11)
	Substance P (2-11)为P物质（SP）片段肽，具有对豚鼠回肠产生收缩活性的特性。同时，Substance P (2-11)能够抑制3H SP在BBMEC单分子层中的渗透。
T76453	Substance P (6-11)
	Substance P (6-11)，Substance P 的C末端六肽酰胺，可与NK-1速激肽受体结合，展现出对运动神经元的去极化作用以及降压效应。
T76454	Substance P (5-11)
	Substance P (5-11) 是 Substance P (Substance P ) 的 C 端七肽，是一种神经肽，可以与NK-1速激肽受体结合。
T81078	Substance P (3-11)
	Substance P (3-11)，作为P 物质 (SP) 的片段肽，具备穿透血脑屏障的能力，且对豚鼠回肠显示出收缩活性。
T76483	[Sar4] Substance P (4-11)
	[Sar4] Substance P (4-11)为Substance P (4-11)的类似物，后者是Substance P (Substance P) C端片段并充当Substance P激动剂。
T76403	[Glp5] Substance P (5-11)
	[Glp5] Substance P (5-11)为一八肽，为大鼠中枢神经系统(CNS)主要P物质片段之一，局部调节大鼠纹状体多巴胺释放。
T76447	[DAla4] Substance P (4-11)
	[DAla4] Substance P (4-11) 作为Substance P的衍生物，能够有效抑制125I-Bolton Hunter标记的Eledoisin（IC50值为0.5 μM）及125I-Bolton Hunter标记的Substance P (IC50值为0.15 μM)与大鼠大脑皮层膜之间的结合。
T76402	[Glp6] Substance P (6-11)
	[Glp6] Substance P (6-11)为Substance P (6-11)的一种类似物，主要通过激活大鼠膀胱中的“隔膜敏感”速激素受体，促进[3H]-单磷酸肌醇 ([3H]-IP1)的生成。
T75769	[Sar9,Met(O2)11]-Substance P TFA
	[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽NK1受体激动剂。
T76462	[Glp5,Sar9] Substance P (5-11)
	[Glp5,Sar9] Substance P (5-11) 是一种Substance P 的类似物。
T76477	[His11]Substance P
	[His11]Substance P 是 Substance P (Substance P ) 的类似物。Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。
T76476	[Gly11] Substance P
	[Gly11] Substance P 是 Substance P (Substance P ) 的类似物。Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。
T76406	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)
	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) 为高效的神经激肽 NK1 拮抗剂，能够有效抑制金蛋白 P 物质 (GPSP) 与 P 物质 (SP) 的活性。
T83496	[D-Pro4,D-Trp7,9,10] Substance P (4-11)
	[D-Pro4,D-Trp7,9,10] Substance P (4-11) 是一种tachykinin拮抗剂，具有高效性。
T83495	[D-Pro4,D-Trp7,9] Substance P (4-11)
	[D-Pro4,D-Trp7,9]Substance P(4-11)为高效Substance P 拮抗剂，可降低血浆醛固酮(ALDO)浓度。
T76404	[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
	[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) 是一种 Substance P 类似物，在大鼠大脑中对神经激肽 1 受体 (NK1R) 的作用与 Substance P 大致相等，但作用时间大大延长。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 能选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 还可增加大鼠运动活性，诱导成瘾剂寻求行为的恢复。
T76484	[Tyr8,Nle11] Substance P
	[Tyr8,Nle11] Substance P 是 Substance P 的类似物。Substance P 是一种主要由神经元分泌的肽，参与许多生物学过程，包括痛觉和炎症。
T76445	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P
	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P 是神经肽 Substance P 的拮抗剂。
T83548	(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate
	'(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate)' 是一种对 Substance P 及 Bombesin 担任拮抗作用的化合物，能针对眼部三叉神经反向刺激引起的炎症反应产生效果。
T64608	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64608。
TP1087	Substance P Neurokinin P,P物质	Endogenous Metabolite; Neurokinin receptor	GPCR/G Protein; Metabolism; Neuroscience
	Substance P (Neurokinin P) 是一种神经肽，其内源性受体是神经激肽1受体，在中枢神经系统中作为神经递质和神经调节剂。
TP1862L	[Sar9] Substance P acetate(77128-75-7 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9] Substance P acetate(77128-75-7 free base) 是一种 NK-1 受体激动剂。 rNK1 特异性激动剂 [Sar-9,Met(O2)11]-SP 模拟了 SP 对孕酮代谢的作用。
T14765	BOS-172722	Kinesin	Cytoskeletal Signaling
	BOS-172722 是一种单极纺锤体 1 (MPS1) 检查点抑制剂，对MPS1 (1 mM ATP) 和P-MPS1 的IC50值分别为 11 nM 和 63 nM。它可研究多种乳腺癌。
T25122	Awl 60 Awl-60,Awl60,Tyr-pro-D-phe-phe-D-phe-D-trp-metnh2
	Awl 60 is a substance P (6-11) non-competitive antagonist.
T78069	RPR132595A hydrochloride NPC hydrochloride	Drug Metabolite	Metabolism
	RPR132595A (NPC) hydrochloride，CPT-11的活性代谢产物，由细胞色素P-450 3A4 (CYP3A4) 催化产生，经尿液排出体外。
TP1087L	Substance P acetate (87616-84-0 Free base)
	Substance P acetate (87616-84-0 Free base) 是一种十一肽（由11个氨基酸残基链组成的肽），属于速激肽神经肽家族。
T70456	Nolpitantium Free Base
	Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff...
T73466	Pulixin
	Pulixin 阻碍了 FREP1 与恶性疟原虫感染细胞的裂解物的结合，防止传播至蚊子，其中EC50值为11 µM。同时，Pulixin 抑制无性期恶性疟原虫的增殖，EC50值达47 nM。
TP1932	[D-Trp7,9,10]-Substance P
	Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
T60301	(Z)-p-cyano-α-Cyanostilbene
	(Z)-p-cyano-α-Cyanostilbene (compound 11) 是一种 phenantrene 衍生物，具有抗增殖活性。(Z)-p-cyano-α-Cyanostilbene 对 HeLa (IC50=0.21 μM) 和 HepG2 (IC50=0.230 μM) 细胞显示出显着的选择性，对正常皮肤成纤维细胞没有细胞毒性 (IC50>100 μM)。
T75726	ω-Conotoxin MVIIC TFA
	ω-Conotoxin MVIIC TFA 是一种阻断N和P/Q型钙通道(Ca2+ channel)的化合物，能显著抑制由11-keto-βboswellic acid介导的谷氨酸释放。
T19553	RPR132595A NPC	Others	Others
	RPR132595A is an active CPT-11 metabolite, it is generated by cytochrome P-450 3A4 (CYP3A4).
TP1862	[Sar9] Substance P
	[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
T29186	YM49598 YM-49598,YM 49598
	YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 +/- 0.02) and NK(2) (pK(i) = 9.94 +/- 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +/
TMIH-0002	(+/-)-Verapamil hydrochloride-d7
	(+/-)-Verapamil hydrochloride-d7 是 (+/-)-Verapamil hydrochloride 的氘代化合物。(+/-)-Verapamil hydrochloride 的 CAS 号为 152-11-4。Verapamil hydrochloride 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T62752	KRAS inhibitor-16
	KRAS inhibitor-16 (compound 3-11) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.457 μM)。KRAS inhibitor-16 在 MIA PaCA-2，A549 细胞中表现出 p-ERK 抑制作用，IC50s 分别为 3.06，11.1 μM。 KRAS inhibitor-16 具有潜力进行胰腺癌，结直肠癌和肺癌的研究。
T79438	c-Myc inhibitor 11	c-Myc	Cell Cycle/Checkpoint
	c-Myc inhibitor11（Compound 67e），一种c-MYC抑制剂（pEC50: 6.4），在大鼠药代动力学评估中表现出高清除率、中等体积分布和短半衰期，适用于癌症研究领域。
T35926	Bz-IEGR-pNA (acetate)
	Bz-IEGR-pNA is a colorimetric substrate for Factor Xa.1 Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.References1. Aruell, L., Friberger, P., Karlsson, G., et al. A new sensitive and highly specific chromogenic peptide substrate for factor Xa. Thromb. Res. 11(5), 595-609 (1977). Bz-IEGR-pNA is a colorimetric substrate for Fact...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9（compound 11）是一种有效Keap1-Nrf2PPI抑制剂，IC50为0.575 µM。该化合物能够提升Nrf2靶基因表达，涉及血红素加氧酶1 (Hmox1)、谷胱甘肽S转移酶P (GstP) 以及谷氨酸-半胱氨酸连接酶的催化(Gclc)与调节(Gclm)亚基。在ARPE19细胞中，Keap1-Nrf2-IN-9展现出无细胞毒活性。

化合物

Substance P (7-11)

Cat.No: T7554

Synonym: Substance P 7-11(TFA)

Target: Others, Neurokinin receptor

Cat.No: TP1879L1

Target: Integrin

[Sar9,Met(O2)11]-Substance P acetate

Cat.No: TP1369L

Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)

Target: Neurokinin receptor

[Sar9,Met(O2)11]-Substance P

Cat.No: T7828

Synonym: Bhsar-sp,NA,精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺

Target: Neurokinin receptor

Cat.No: T34081

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Oligopeptide P11-4 acetate(593266-60-5 free base)

Cat.No: TP2326L

Target: Others

[Sar9,Met(O2)11]-Substance P TFA(110880-55-2,free)

Cat.No: TP1369

Synonym: [Sar9,Met(O2)11]-Substance P TFA

Cat.No: TP2352

Synonym: Substance P (6-11), pyroglutamyl(6)-proline(9)-,6-Glp-9-pro-substance P (6-11)

[Nle11]-Substance P

Cat.No: TP1831

Cat.No: TP1879

Synonym: P11

Substance P (4-11)

Cat.No: T76455

Substance P (2-11)

Cat.No: T81079

Substance P (6-11)

Cat.No: T76453

Substance P (5-11)

Cat.No: T76454

Substance P (3-11)

Cat.No: T81078

[Sar4] Substance P (4-11)

Cat.No: T76483

[Glp5] Substance P (5-11)

Cat.No: T76403

[DAla4] Substance P (4-11)

Cat.No: T76447

[Glp6] Substance P (6-11)

Cat.No: T76402

[Sar9,Met(O2)11]-Substance P TFA

Cat.No: T75769

[Glp5,Sar9] Substance P (5-11)

Cat.No: T76462

[His11]Substance P

Cat.No: T76477

[Gly11] Substance P

Cat.No: T76476

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)

Cat.No: T76406

[D-Pro4,D-Trp7,9,10] Substance P (4-11)

Cat.No: T83496

[D-Pro4,D-Trp7,9] Substance P (4-11)

Cat.No: T83495

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

Cat.No: T76404

[Tyr8,Nle11] Substance P

Cat.No: T76484

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P

Cat.No: T76445

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

Cat.No: T83548

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R

Cat.No: T64608

Cat.No: TP1087

Synonym: Neurokinin P,P物质

Target: Endogenous Metabolite, Neurokinin receptor

[Sar9] Substance P acetate(77128-75-7 free base)

Cat.No: TP1862L

Target: Neurokinin receptor

Cat.No: T14765

Target: Kinesin

Cat.No: T25122

Synonym: Awl-60,Awl60,Tyr-pro-D-phe-phe-D-phe-D-trp-metnh2

RPR132595A hydrochloride

Cat.No: T78069

Synonym: NPC hydrochloride

Target: Drug Metabolite

Substance P acetate (87616-84-0 Free base)

Cat.No: TP1087L

Nolpitantium Free Base

Cat.No: T70456

Cat.No: T73466

[D-Trp7,9,10]-Substance P

Cat.No: TP1932

(Z)-p-cyano-α-Cyanostilbene

Cat.No: T60301

ω-Conotoxin MVIIC TFA

Cat.No: T75726

Cat.No: T19553

Synonym: NPC

Target: Others

[Sar9] Substance P

Cat.No: TP1862

Cat.No: T29186

Synonym: YM-49598,YM 49598

(+/-)-Verapamil hydrochloride-d7

Cat.No: TMIH-0002

KRAS inhibitor-16

Cat.No: T62752

c-Myc inhibitor 11

Cat.No: T79438

Target: c-Myc

Bz-IEGR-pNA (acetate)

Cat.No: T35926

Keap1-Nrf2-IN-9

Cat.No: T74600

Cat. No.	Product Name	Target	Signaling Pathways
T37690	Phenylpyropene A
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 \|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...
T36179	Aspulvinone O
	Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Phenylpyropene A

Cat.No: T37690

Cat.No: T36179

3-Hydroxyterphenyllin

Cat.No: T36000

Cat.No: T35624

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上海市静安区江场三路238号8楼