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Search Results for " nicotinic acid "

26

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0664	Nicotinic acid hydrazide	Others	Others
	Nicotinic acid hydrazide（NAH）是烟酸的酰肼衍生物，一种杂环有机物，是过氧化物酶抑制剂，可以形成具有较强生物活性的固态金属配合物。
T0067	Nicotinic acid N-oxide 烟酸-N-氧化物,Nicotinic acid 1-oxide,氧烟酸,Oxiniacic Acid	Others	Others
	Nicotinic acid N-oxide (Nicotinic acid 1-oxide) 是一种烟酸衍生物，用于治疗高脂血症。
T25867	Nicodan Percutan Nicotinic acid, propyl ester,Propylnicotinat,烟酸丙酯,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447	Others	Others
	Nicodan Percutan (Propylnicotinat) 是烟酸的丙酯形式，烟酸在各种动物和植物组织中存在，用于形成辅酶NAD 和NADP。
T19438	Myristyl nicotinate Tetradecyl nicotinate,肉豆蔻醇烟酸酯	GPR	Endocrinology/Hormones; GPCR/G Protein
	Myristyl nicotinate (Tetradecyl nicotinate) 是 Nicotinic acid 的亲脂衍生物，是一种酯前药。它能够刺激光损伤的皮肤中的表皮分化，增加皮肤 NAD 含量并增强人皮肤屏障。它被开发用于将烟酸输送到皮肤中，以防止光化性角化病及其发展为皮肤癌。
T72188	Nicotinamide Hydrochloride Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式，可抑制SIRT2的体外活性，其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量，并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率，可用于黑色素瘤等皮肤癌相关的研究。
T1162	Acipimox Olbemox,K-9321,阿西莫司,阿昔莫司	Others	Others
	Acipimox (K-9321) 是烟酸类似物，能够急性抑制脂解作用，抑制全身游离脂肪水平，改善胰岛素敏感性。
T83801	ε-NAADP+ sodium Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate
	ε-NAADP+是钙动员诱导剂NAADP的荧光衍生物。在海胆卵细胞匀浆中诱导钙释放(EC50 = 5 µM)。ε-NAADP+在275 nm和410 nm分别显示激发/发射峰值，且在DMSO中的相对发射增加了三倍。
T20418	Tocopherol nicotinate Vitamin E nicotinate,Vitamin E nicotinic acid ester,Tocopheryl nicotinate
	Tocopherol nicotinate is an antioxidant. It is used for skin conditioning.
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T71359	ArgTX-93 TFA
	ArgTX-93 is a highly potent and subfamily selective antagonist of the NMDARs and AMPARs.
T34573	SCH-900271 SCH 900271	AChR	Neuroscience
	SCH-900271是一种有效的尼古丁酸受体，用于治疗血脂异常,常用来研究混合性高脂血症和原发性高胆固醇血症。
TP2063L	α-Conotoxin MII acetate α-Conotoxin MII acetate (175735-93-0 Free base)	AChR	Neuroscience
	α-Conotoxin MII acetate 是一种来自海洋蜗牛 Conus magus 毒液的 16 个氨基酸肽。它有效阻断由 α3β2 亚基组成的烟碱型乙酰胆碱受体，IC50 为 0.5 nM。它可有效阻断含 β3 的神经元烟碱乙酰胆碱受体。
T1299	3-Pyridinemethanol 烟醇,Nicotinyl alcohol,Roniacol	Others	Others
	3-Pyridinemethanol (Roniacol) 是一种具有降胆固醇作用的吡啶衍生物。
TQ0108	MK-6892	GPR	Endocrinology/Hormones; GPCR/G Protein
	MK-6892 是烟酸受体GPR109A 选择性激动剂。它作用于人 GPR109A 的Ki=4 nM，EC50=16 nM。
T60364	DHODH-IN-17	Dehydrogenase	Metabolism
	DHODH-IN-17是一种人DHODH抑制剂，IC50为0.40 μM。DHODH-IN-17 是一种 2- 苯胺酰烟酸，可用于研究急性髓系白血病 (AML) 。
T22670	cis-Ned 19	Others	Others
	nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist
T26201	Sorbinicate LG10017,Sorbinicatum,LG10,017,LG-10017,LG 10017
	Sorbinicate is an antihypercholesterolaemic and vasodilating nicotinic acid ester.
T32441	L 44-0 L44-0,L-44-0
	L 44-0 is a nicotinic acid derivative.
T68745	U 56324
	U-56324 is a hypoglycemic agent derived from nicotinic acid. It was found to inhibit the activity of ATP-sensitive potassium channels in excised patches from mouse pancreatic B-cells.
T75878	Catestatin TFA
	Catestatin TFA，一个含有21个氨基酸残基、阳离子性疏水性肽，作为内源性肽，调节心脏功能及血压。它通过烟碱型乙酰胆碱受体(nAChRs)以非竞争性方式抑制儿茶酚胺释放，功能为烟碱类拮抗剂。
T63649	Ned-K
	Ned-K 是一种烟酸腺嘌呤二核苷酸磷酸 (NAADP) 拮抗剂，对心肌缺血和再灌注 (sIR) 诱导的钙振荡表现出抑制作用。
T72745	Acipimox sodium K-9321 sodium
	Acipimox (K-9321) sodium 为烟酸类似物，能抗脂及抑制脂肪分解。该化合物通过刺激瘦素释放、抑制脂解作用及全身游离脂肪水平，进而改善胰岛素敏感性。
T37293	CMPI hydrochloride
	Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains. Hamouda (2016) Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)3(β2)2 nAChR-selective p...
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, ...
T35922	NAADP (sodium salt)
	Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to...
T83662	2,3-dinor-8-iso Prostaglandin F1α 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP
	2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。

化合物

Nicotinic acid hydrazide

Cat.No: T0664

Target: Others

Nicotinic acid N-oxide

Cat.No: T0067

Synonym: 烟酸-N-氧化物,Nicotinic acid 1-oxide,氧烟酸,Oxiniacic Acid

Target: Others

Nicodan Percutan

Cat.No: T25867

Synonym: Nicotinic acid, propyl ester,Propylnicotinat,烟酸丙酯,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447

Target: Others

Myristyl nicotinate

Cat.No: T19438

Synonym: Tetradecyl nicotinate,肉豆蔻醇烟酸酯

Target: GPR

Nicotinamide Hydrochloride

Cat.No: T72188

Synonym: Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride

Cat.No: T1162

Synonym: Olbemox,K-9321,阿西莫司,阿昔莫司

Target: Others

ε-NAADP+ sodium

Cat.No: T83801

Synonym: Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate

Tocopherol nicotinate

Cat.No: T20418

Synonym: Vitamin E nicotinate,Vitamin E nicotinic acid ester,Tocopheryl nicotinate

Nicotinamide-d4

Cat.No: T69395

Cat.No: T71359

Cat.No: T34573

Synonym: SCH 900271

Target: AChR

α-Conotoxin MII acetate

Cat.No: TP2063L

Synonym: α-Conotoxin MII acetate (175735-93-0 Free base)

Target: AChR

3-Pyridinemethanol

Cat.No: T1299

Synonym: 烟醇,Nicotinyl alcohol,Roniacol

Target: Others

Cat.No: TQ0108

Target: GPR

Cat.No: T60364

Target: Dehydrogenase

Cat.No: T22670

Target: Others

Cat.No: T26201

Synonym: LG10017,Sorbinicatum,LG10,017,LG-10017,LG 10017

Cat.No: T32441

Synonym: L44-0,L-44-0

Cat.No: T68745

Cat.No: T75878

Cat.No: T63649

Acipimox sodium

Cat.No: T72745

Synonym: K-9321 sodium

CMPI hydrochloride

Cat.No: T37293

CHS-828 nicotinate

Cat.No: T71361

NAADP (sodium salt)

Cat.No: T35922

2,3-dinor-8-iso Prostaglandin F1α

Cat.No: T83662

Synonym: 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP

Cat. No.	Product Name	Target	Signaling Pathways
T19477	Nicotinic acid mononucleotide	Others	Others
	Nicotinic acid mononucleotide is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+.
T5233	N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。
T0879	Niacin Vitamin B3,烟酸(维生素B3),Nicotinic acid	Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Niacin (Nicotinic acid)，也称为烟酸和维生素 B3，是一种水溶性必需的 B 族维生素，用于治疗维生素缺乏症以及高脂血症，血脂异常，高甘油三酯血症，并降低心肌梗塞的风险
T2927	Trigonelline chloride Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others; Antibacterial; Antifungal; HSV	Microbiology/Virology; Others
	Trigonelline chloride (Coffearine Hydrochloride) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它还具有抗HSV-1，抗菌和抗真菌活性。
T67407	Nicotinic acid riboside
	Nicotinic acid riboside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T67407，CAS号为 17720-18-2。
TN1643	Ferulamide 4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺	PAFR; AChR	GPCR/G Protein; Neuroscience
	Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物，具有抗胆碱酯酶活性。
T8040	Cholesterol myristate 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate	Others; Potassium Channel; GABA Receptor; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Cholesterol myristate (Cholesteryl myristate) 是粗吻海龙中的一种类固醇，可与多种离子通道结合，例如nAChR、GABAA 受体和内向整流钾离子通道。
T65135	Kynurenic acid Fibrostop 2,Quinurenic acid	GPR; GluR; NMDAR	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物，是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂，也是 GPR35/CXCR8 激动剂，具有神经保护和抗惊厥特性，可用于研究神经分裂和与代谢相关的疾病。
Fr13756	Isonicotinic acid	Endogenous Metabolite; Drug Metabolite	Metabolism
	Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。
T4816	6-Hydroxynicotinic acid 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) 用于核磁共振波谱或气相色谱-质谱法诊断尿路感染中的铜绿假单胞菌。在引起尿液感染的常见细菌中，只有铜绿假单胞菌从烟酸中产生6-羟基烟酸。
T4721	β-Nicotinamide mononucleotide β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-Nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
T19128	3-Pyridineacetic acid	Others	Others
	3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids.

天然产物

Nicotinic acid mononucleotide

Cat.No: T19477

Target: Others

N-Methylnicotinamide

Cat.No: T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺

Target: Others, Endogenous Metabolite

Cat.No: T0879

Synonym: Vitamin B3,烟酸(维生素B3),Nicotinic acid

Target: Endogenous Metabolite, Autophagy

Trigonelline chloride

Cat.No: T2927

Synonym: Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

Nicotinic acid riboside

Cat.No: T67407

Cat.No: TN1643

Synonym: 4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺

Target: PAFR, AChR

Cholesterol myristate

Cat.No: T8040

Synonym: 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Kynurenic acid

Cat.No: T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Isonicotinic acid

Cat.No: Fr13756

Target: Endogenous Metabolite, Drug Metabolite

6-Hydroxynicotinic acid

Cat.No: T4816

Synonym: 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid

Target: Others, Endogenous Metabolite

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

3-Pyridineacetic acid

Cat.No: T19128

Target: Others

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