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Search Results for " nsp "

Targets Recommended: Monoamine Transporter Na-K-Cl cotransporter Monocarboxylate transporter transporter Serotonin Transporter PDE

26

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12267	NSP-805	PDE	Metabolism
	NSP-805 是一种强心剂，是一种选择性的 phosphodiesterase 3 抑制剂，具有舒张血管的作用。
T19040	NSP-SA-NHS	Others	Others
	NSP-SA-NHS 是一种可用于免疫测定的化学发光吖啶酯。
T16985	Tanaproget NSP-989	Others	Others
	Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),
T63615	SARS-CoV-2 nsp13-IN-5
	SARS-CoV-2 nsp13-IN-5 是 SARS-CoV-2 nsp13 的有效抑制剂，能够作用于 ssDNA+ATPase (IC50: 50 μM) 和 ssDNA-ATPase (IC50: 55 μM)。SARS-CoV-2 nsp13-IN-5 能够用于抗 COVID-19 的研究。
T60271	SARS-CoV-2 nsp3-IN-2
	SARS-CoV-2 nsp3-IN-2 是一种 SARS-CoV-2 nsp3 Mac1抑制剂，IC50值为 180 μM。SARS-CoV-2 nsp3 宏结构域是一种 ADP-核糖基水解酶，对冠状病毒的复制和发病机制至关重要。 SARS-CoV-2 nsp3-IN-2 是一种小分子化学探针，可用于研究病毒。
T78725	SARS-CoV-2 nsp14-IN-3	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 nsp14-IN-3 (4975)为一种针对SARS-CoV-2 Nsp14 N7-甲基转移酶的抑制剂，具有IC50值为7 μM。
T62819	SARS-CoV-2 nsp14-IN-2
	SARS-CoV-2 nsp14-IN-2 是一种 SARS-CoV-2 Nsp14 甲基转移酶 (SARS-CoV-2 Nsp14 methyltransferase) 的有效抑制剂 (IC50: 0.093 μM)。SARS-CoV-2 nsp14-IN-2 具有抗病毒活性，并表现出血浆和肝脏 S9 稳定性。SARS-CoV-2 nsp14-IN-2 具有潜力进行 COVID-19 的研究。
T62829	SARS-CoV-2 nsp14-IN-1
	SARS-CoV-2 nsp14-IN-1 (Compound 3) 是一种典型的 SARS-CoV-2Nsp14 Mtase 双底物抑制剂 (IC50: 0.061 μM)。SARS-CoV-2 nsp14-IN-1 对人类甲基转移酶表现出良好的选择性，可拮抗 10 种人甲基转移酶（如组蛋白赖氨酸、蛋白精氨酸、DNA 和 RNA 等）。
T62248	SARS-CoV-2 nsp13-IN-6
	SARS-CoV-2 nsp13-IN-6 (compound C5) 是一种 SARS-CoV-2 非结构蛋白 13 (nsp13) 的有效抑制剂，能够作用于 ssDNA+ATPase (IC50: 27 μM)和 ssDNA-ATPase (IC50: 33 μM)。SARS-CoV-2 nsp13-IN-6 可以用于抗 COVID-19 的研究。
T60861	SARS-CoV-2 nsp3-IN-1
	SARS-CoV-2 nsp3-IN-1 (Compound 15c) 对冠状病毒的大结构域，尤其是 SARS-CoV-2 Mac1，表现出显著性的选择性。SARS-CoV-2 nsp3-IN-1 可抑制 Mac1 ADP-核苷酸水解酶的活性，是 Mac1的抑制剂 (IC50 = 6.1 μM)。
T62031	SARS-CoV-2 nsp13-IN-4
	SARS-CoV-2 nsp13-IN -4 (C4 (d)) 是强效的、选择性的 nsp13 helicase 小分子抑制剂。SARS-CoV-2 nsp13-IN -4 抑制 nsp13 的 ssDNA+ ATPase 活性，IC50值为57 μM。SARS-CoV-2 nsp13-IN-4 显示广谱抗病毒作用。
T62264	SARS-CoV-2 nsp13-IN-2
	SARS-CoV-2 nsp13-IN-2 (Compound C2) 是一种 SARS-CoV-2 非结构蛋白 13（nsp13）小分子抑制剂，能够作用于 nsp13 ssDNA+ATPase (IC50: 42 μM)。
T62375	SARS-CoV-2 nsp13-IN-3
	SARS-CoV-2 nsp13-IN-3 (Compound C3) 是一种 SARS-CoV-2 非结构蛋白 13（nsp13）小分子抑制剂，能够作用于 nsp13 ssDNA+ATPase (IC50: 32 μM)。
T79526	SARS-CoV-2 nsp14-IN-4	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 nsp14-IN-4（Compound 12q）是针对SARS-CoV-2 nsp14甲基转移酶的抑制剂，具有19 nM的IC50值。此化合物没有细胞毒性，并且可穿过细胞膜。它被应用于COVID-19的相关研究。
T62413	SARS-CoV-2 nsp13-IN-1
	SARS-CoV-2 nsp13-IN-1 (compound C1) 是一种 nsp13 (非结构蛋白 13) 的有效抑制剂。SARS-CoV-2 nsp13-IN-1 只抑制nsp13 ssDNA+ATPase (IC50: 6 μM)，不抑制 ssDNA-ATPase。SARS-CoV-2 nsp13-IN-1 能够用于研究 COVID-19。
T0383	Fenspiride hydrochloride Fenspiride HCl,Pneumorel,Fluiden,Decaspiride,盐酸芬司必利	Adrenergic Receptor; PDE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Fenspiride hydrochloride (Decaspiride) 是一种口服活性的非甾体抗炎剂，是 H1-组胺受体的拮抗剂，可用于呼吸系统疾病的研究。
T125993	Schisansphenin B
	Schisansphenin B 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125993，CAS号为 1357469-93-2。
TP1849	Transportan
	Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine.
T35060	VinSpinIn Vinnie's Spindlin Inhibitor,TD020824a
	VinSpinIn is a probe for the Spin family proteins.
T71141	Fenspiride-d5
	Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...
T126361	Epidanshenspiroketallactone
	Epidanshenspiroketallactone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126361。
T81962	Lactate transportor 1	Monocarboxylate transporter	Membrane transporter/Ion channel
	Lactate transporter 1 (compound 1) 作为一种活性乳酸运输蛋白，主要在活细胞内发挥作用。在Hela、CAL27、MCF7和MCF10A细胞系中，Lactate transporter 1 均显示出了明显的毒性，其半抑制浓度（IC50）值依次为3.36、3.27、5.58和7.66 μM。此外，在HeLa细胞中，Lactate transporter 1 与Cisplatin表现出了协同抑制的作用。
T60417	Fenspiride
	Fenspiride 是 H1-组胺受体的拮抗剂。 Fenspiride 是一种具有口服活性的非甾体类抗炎药，可用于治疗呼吸道感染和中耳炎。 Fenspiride 抑制磷酸二酯酶 4 和磷酸二酯酶 3 的活性，-logIC50 值分别为 4.16+/-0.09 和 3.44+/-0.12。磷酸二酯酶 5 活性也受到抑制，-logIC50 值约为 3.8。
T126549	Danshinspiroketallactone
	Danshinspiroketallactone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126549。
T35059	VinSpinIC Vinnie's Spindlin Inactive Control,TD020826a
	VinSpinIC is an inactive control for VinSpinIn.
T62494	Cathepsin C-IN-5
	CathepsinC-IN-5 (compound SF38) 为一高效、选择性、口服活性的组织蛋白酶 C (Cat C) 抑制剂，其针对Cat C、Cat L、Cat S、Cat B、Cat K 的IC50s 分别为 59.9 nM、4.26 µM、>5 µM、>5 µM、>5 µM。该化合物能够抑制骨髓和血液中的Cat C活性，降低中性粒细胞丝氨酸蛋白酶（NSP）的激活，并展现抗炎活性。

化合物

Cat.No: T12267

Target: PDE

Cat.No: T19040

Target: Others

Cat.No: T16985

Synonym: NSP-989

Target: Others

SARS-CoV-2 nsp13-IN-5

Cat.No: T63615

SARS-CoV-2 nsp3-IN-2

Cat.No: T60271

SARS-CoV-2 nsp14-IN-3

Cat.No: T78725

Target: SARS-CoV

SARS-CoV-2 nsp14-IN-2

Cat.No: T62819

SARS-CoV-2 nsp14-IN-1

Cat.No: T62829

SARS-CoV-2 nsp13-IN-6

Cat.No: T62248

SARS-CoV-2 nsp3-IN-1

Cat.No: T60861

SARS-CoV-2 nsp13-IN-4

Cat.No: T62031

SARS-CoV-2 nsp13-IN-2

Cat.No: T62264

SARS-CoV-2 nsp13-IN-3

Cat.No: T62375

SARS-CoV-2 nsp14-IN-4

Cat.No: T79526

Target: SARS-CoV

SARS-CoV-2 nsp13-IN-1

Cat.No: T62413

Fenspiride hydrochloride

Cat.No: T0383

Synonym: Fenspiride HCl,Pneumorel,Fluiden,Decaspiride,盐酸芬司必利

Target: Adrenergic Receptor, PDE, Histamine Receptor

Schisansphenin B

Cat.No: T125993

Cat.No: TP1849

Cat.No: T35060

Synonym: Vinnie's Spindlin Inhibitor,TD020824a

Cat.No: T71141

Epidanshenspiroketallactone

Cat.No: T126361

Lactate transportor 1

Cat.No: T81962

Target: Monocarboxylate transporter

Cat.No: T60417

Danshinspiroketallactone

Cat.No: T126549

Cat.No: T35059

Synonym: Vinnie's Spindlin Inactive Control,TD020826a

Cathepsin C-IN-5

Cat.No: T62494

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02001	RTN4 Protein, Human, Recombinant (GST) UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X,NSP<...	Human	E. coli
	Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ...
TMPY-06011	SARS-CoV-2 NSP10 Protein (His)	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 15.7 ...
TMPY-05749	SARS-CoV-2 NSP8 Protein (Avi)	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num...
TMPY-06012	SARS-CoV-2 NSP10 Protein	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and ...
TMPJ-01427	SARS-CoV-2 NSP7 Protein (His) SARS-CoV 2 nsp7	SARS-CoV-2	E. coli
	The ∼30kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural proteins (nsps). The four proteins nsp7 to nsp10, which are conserved among all CoVs but have no functional homologs outside of the Coronaviridae, are translated as part of the viral polyproteins pp1a and pp1ab, and the mature proteins are released by the action of the SARS-CoV protease nsp5. Hexadecamer of nsp7 and nsp8 may possess dsRN...
TMPY-06416	SARS-CoV-2 NSP8 Protein	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is...
TMPJ-01425	SARS-CoV-2 NSP1 Protein (His) SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein	SARS-CoV-2	E. coli
	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close associa...
TMPJ-01426	SARS-CoV-2 NSP2 Protein (His) SARS-CoV 2 nsp2,SARS-CoV 2 p65 homolog	SARS-CoV-2	E. coli
	The positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development.
TMPY-05820	SARS-CoV-2 NSP3 Protein (His)	SARS-CoV-2	E. coli
	SARS-CoV-2 NSP3 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 19.87 kDa and the accession number is YP_009725299.1.
TMPY-06009	SARS-CoV-2 NSP7 Protein	SARS-CoV-2	E. coli
	NSP7 is conserved within the coronaviridae. NSP7 is a component of the coronavirus replicase polyprotein to comprise a repilication complex. NSP7 has been shown to interact with NSP10 and NSP1 which indicate that NSP7 has a founction in coronavirus-specific RNA replication mechanisms.
TMPJ-01428	SARS-CoV-2 NSP8 Protein (His) SARS-CoV 2 nsp8	SARS-CoV-2	E. coli
	Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependen...
TMPY-05712	SARS-CoV-2 NSP9 Protein (His & Avi)	SARS-CoV-2	E. coli
	SARS-CoV-2 NSP9 Protein (His & Avi) is expressed in E. coli expression system. The predicted molecular weight is 15.46 kDa and the accession number is YP_009725305.1.
TMPH-03491	SARS-CoV-2 Non-structural protein 9/NSP9 Protein (His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Non-structural protein 9/NSP9 Protein (His) is expressed in E. coli.
TMPH-03489	SARS-CoV-2 3C-like proteinase NSP5 Protein (His)	SARS-CoV-2	E. coli
	SARS-CoV-2 3C-like proteinase NSP5 Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is YP_009725301.1.
TMPH-03490	SARS-CoV-2 Non-structural protein 3/NSP3 Protein (His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Non-structural protein 3/NSP3 Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 41.7 kDa and the accession number is YP_009725299.1.
TMPH-03492	SARS-CoV-2 Non-structural protein 9/NSP9 Protein (Flag & hFc)	SARS-CoV-2	HEK293 Cells
	SARS-CoV-2 Non-structural protein 9/NSP9 Protein (Flag & hFc) is expressed in HEK293 mammalian cells with C-hFC-Flag tag. The predicted molecular weight is 44.5 kDa and the accession number is P0DTD1 YP_009742616.1.
TMPH-00206	Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO)	Bordetella pertussis	E. coli
	Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.8 kDa and the accession number is P14283.
TMPJ-01429	SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) SARS-CoV 2 nsp14,Guanine-N7 methyltransferase,SARS-...	SARS-CoV-2	E. coli
	The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.

重组蛋白

RTN4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02001

Species: Human

Expression System: E. coli

SARS-CoV-2 NSP10 Protein (His)

Cat.No: TMPY-06011

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (Avi)

Cat.No: TMPY-05749

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP10 Protein

Cat.No: TMPY-06012

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP7 Protein (His)

Cat.No: TMPJ-01427

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein

Cat.No: TMPY-06416

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP1 Protein (His)

Cat.No: TMPJ-01425

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP2 Protein (His)

Cat.No: TMPJ-01426

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP3 Protein (His)

Cat.No: TMPY-05820

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP7 Protein

Cat.No: TMPY-06009

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (His)

Cat.No: TMPJ-01428

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP9 Protein (His & Avi)

Cat.No: TMPY-05712

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Non-structural protein 9/NSP9 Protein (His)

Cat.No: TMPH-03491

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 3C-like proteinase NSP5 Protein (His)

Cat.No: TMPH-03489

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Non-structural protein 3/NSP3 Protein (His)

Cat.No: TMPH-03490

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Non-structural protein 9/NSP9 Protein (Flag & hFc)

Cat.No: TMPH-03492

Species: SARS-CoV-2

Expression System: HEK293 Cells

Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO)

Cat.No: TMPH-00206

Species: Bordetella pertussis

Expression System: E. coli

SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)

Cat.No: TMPJ-01429

Species: SARS-CoV-2

Expression System: E. coli

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