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21

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3575	Acecainide hydrochloride ASL 601,NAPA	Others	Others
	Acecainide hydrochloride (NAPA) 是 PROCAINAMIDE 的主要代谢物。其抗心律失常作用可能导致肾衰竭时的心脏毒性。
T0249	N-Acetylprocainamide NAPA,Acecainide,乙酰普卡胺,N-乙酰普鲁卡因胺	Potassium Channel; Sodium Channel; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	N-Acetylprocainamide (NAPA) 是K+通道抑制剂，是第三代抗心律失常剂。
T60097	Methyl (E)-sinapate	Others	Others
	methyl (E)-sinapate 从 Polygala sibirica L.var. megalopha Fr 中分离得到。
T3218	Napabucasin BBI608	STAT	JAK/STAT signaling; Stem Cells
	Napabucasin (BBI608) 是一种口服的 Stat3 和 Y 干细胞活性抑制剂。
T0113	Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。
T9593	Senaparib IMP4297	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂，具有强效的抗肿瘤活性。
T6007	Birinapant TL32711,比瑞那帕	Apoptosis; IAP; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Birinapant (TL32711) 是一种二价 Smac 模拟物，是 XIAP 和 cIAP1的强效拮抗剂，Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP，并消除 TNF 诱导的 NF-κB 活化。
T6763	Xevinapant ARRY-334543,SM-406,AT406,Debio-1143	IAP	Apoptosis
	Xevinapant (Debio-1143) 是一种有效的 Smac 模拟物和 IAP 的拮抗剂，能够抑制 XIAP，cIAP1 和 cIAP2 蛋白，Ki 值分别为 66.4，1.9 和 5.1 nM。
T7587	Tenapanor RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722	Sodium Channel	Membrane transporter/Ion channel
	Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。
T16802	Lonapalene RS4317,氯萘帕林	Others	Others
	Lonapalene is a topically effective inhibitor of 5-lipoxygenase.
T26553	Aclatonium Napadisilate Acaltonium napadisilate
	Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.
T24995	Abediterol napadisylate LAS100977 napadisylate
	Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.
T3299	Xevinapant hydrochloride AT-406 HCl,SM-406	Apoptosis; IAP	Apoptosis
	Xevinapant hydrochloride (AT-406 HCl) 是口服生物可利用的 Smac 模拟物，也是细胞凋亡蛋白抑制剂的拮抗剂。它在无细胞功能测定中有效拮抗 XIAP BIR3 蛋白，诱导细胞 cIAP1 蛋白的快速降解，并抑制各种人类癌细胞系中的癌细胞生长。它在诱导异种移植肿瘤细胞凋亡方面非常有效。
T35940	Darinaparsin Dimethylarsinic glutathione,Darinaparsin
	Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...
T13405	Fanapanel hydrate MPQX hydrate,ZK200775 (hydrate)	Others	Others
	Fanapanel hydrate is a highly selective antagonist of AMPA/kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively).
T13405L	Fanapanel MPQX,ZK200775	Others	Others
	Fanapanel is a highly selective AMPA/kainate antagonist with little activity against NMDA. It also has Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
T7587L	Tenapanor HCl RDX-5791,AZD 1722,AZD-1722,AZD1722,RDX5791,RDX 5791
	Tenapanor( AZD-1722, RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which is used for sodium handling in the gastrointestinal tract and kidney.
T40572	Lesogaberan napadisylate AZD-3355 napadisylate
	Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, as determined by its displacement of [3H]GABA binding in brain membranes. Notably, Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.
T70762	Senaparib hydrochloride
	Senaparib hydrochloride is a potent and selective oral PARP1/2 inhibitor with strong antitumor activity.
T28131	Napamezole WIN51181,WIN-51181,WIN 51181
	Napamezole is an α2 adrenergic receptor antagonist. Napamezole antagonizes methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. Napamezole reverses clonidine-induced decreased in twitch height in the electrically stimula
T32827	L-Napamp
	L-Napamp is a bioactive chemical.

化合物

Acecainide hydrochloride

Cat.No: T3575

Synonym: ASL 601,NAPA

Target: Others

N-Acetylprocainamide

Cat.No: T0249

Synonym: NAPA,Acecainide,乙酰普卡胺,N-乙酰普鲁卡因胺

Target: Potassium Channel, Sodium Channel, Drug Metabolite

Methyl (E)-sinapate

Cat.No: T60097

Target: Others

Cat.No: T3218

Synonym: BBI608

Target: STAT

Mebhydrolin napadisylate

Cat.No: T0113

Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline

Target: 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T9593

Synonym: IMP4297

Target: PARP

Cat.No: T6007

Synonym: TL32711,比瑞那帕

Target: Apoptosis, IAP, HIV Protease

Cat.No: T6763

Synonym: ARRY-334543,SM-406,AT406,Debio-1143

Target: IAP

Cat.No: T7587

Synonym: RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722

Target: Sodium Channel

Cat.No: T16802

Synonym: RS4317,氯萘帕林

Target: Others

Aclatonium Napadisilate

Cat.No: T26553

Synonym: Acaltonium napadisilate

Abediterol napadisylate

Cat.No: T24995

Synonym: LAS100977 napadisylate

Xevinapant hydrochloride

Cat.No: T3299

Synonym: AT-406 HCl,SM-406

Target: Apoptosis, IAP

Cat.No: T35940

Synonym: Dimethylarsinic glutathione,Darinaparsin

Fanapanel hydrate

Cat.No: T13405

Synonym: MPQX hydrate,ZK200775 (hydrate)

Target: Others

Cat.No: T13405L

Synonym: MPQX,ZK200775

Target: Others

Cat.No: T7587L

Synonym: RDX-5791,AZD 1722,AZD-1722,AZD1722,RDX5791,RDX 5791

Lesogaberan napadisylate

Cat.No: T40572

Synonym: AZD-3355 napadisylate

Senaparib hydrochloride

Cat.No: T70762

Cat.No: T28131

Synonym: WIN51181,WIN-51181,WIN 51181

Cat.No: T32827

Cat. No.	Product Name	Target	Signaling Pathways
TN2281	Sinapaldehyde trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛	Antibacterial	Microbiology/Virology
	Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用，MIC 值都为 128 μg/mL。
TN5027	Sinapaldehyde glucoside	Others	Others
	Sinapaldehyde glucoside是一种天然产物，属于芸香科黄柏属，其产品编号为 TN5027，CAS号为 154461-65-1。Sinapaldehyde glucoside可用作对照参考。
TN6365	3-Deoxy-11,13-dihydroisosecotanapartholide
	3-Deoxy-11,13-dihydroisosecotanapartholide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6365，CAS号为 572924-43-7。
TN1929	Methyl sinapate 芥子酸甲酯	Others	Others
	Methyl sinapate can increase the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV.

天然产物

Cat.No: TN2281

Synonym: trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛

Target: Antibacterial

Sinapaldehyde glucoside

Cat.No: TN5027

Target: Others

3-Deoxy-11,13-dihydroisosecotanapartholide

Cat.No: TN6365

Methyl sinapate

Cat.No: TN1929

Synonym: 芥子酸甲酯

Target: Others

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