Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Napabucasin (BBI608) 是一种口服的 Stat3 和 Y 干细胞活性抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 277 | 现货 | ||
5 mg | ¥ 597 | 现货 | ||
10 mg | ¥ 925 | 现货 | ||
25 mg | ¥ 1,683 | 现货 | ||
50 mg | ¥ 2,868 | 现货 | ||
100 mg | ¥ 3,590 | 现货 | ||
200 mg | ¥ 5,190 | 现货 | ||
500 mg | ¥ 8,090 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 664 | 现货 |
产品描述 | Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor. |
体外活性 | Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells. [1] |
体内活性 | In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis. [1] |
细胞实验 | For cancer stem cells, spheres are dissociated and plated under cancer stem cell culture conditions on coated 96-well plates. After 72 h of culture, wells are dosed with the indicated compounds. Seventy-two hours or 24 h after dosing, CellTiter-Glo 2.0 is added to each well, and the luminescence is measured as described by the manufacturer. IC50 values are calculated by fitting a four parameter dose–response curve to normalized data using GraphPad Prism software. For bulk cells, cells are plated at 5,000 cells per well on 96-well plates. Twenty-four hours after plating, cells are treated with the indicated compounds. Viability is determined at 72 h as described above.(Only for Reference) |
别名 | BBI608 |
分子量 | 240.21 |
分子式 | C14H8O4 |
CAS No. | 83280-65-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 6.88 mg/mL (28.62 mM)
acetonitrile: 0.799 mg/ml (3.3278 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / acetonitrile | 1 mM | 4.163 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
DMSO | 5 mM | 0.8326 mL | 4.163 mL | 8.326 mL | 20.8151 mL |
10 mM | 0.4163 mL | 2.0815 mL | 4.163 mL | 10.4076 mL | |
20 mM | 0.2082 mL | 1.0408 mL | 2.0815 mL | 5.2038 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Napabucasin 83280-65-3 JAK/STAT signaling Stem Cells STAT inhibit BBI-608 BBI 608 Inhibitor BBI608 inhibitor