Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fanapanel hydrate is a highly selective antagonist of AMPA/kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 420 | 5日内发货 | ||
100 mg | ¥ 7,570 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,280 | 5日内发货 |
产品描述 | Fanapanel hydrate is a highly selective antagonist of AMPA/kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively). |
体内活性 | In mice, ZK200775 elevated the threshold for AMPA- and kainate-induced clonic seizures with a THRD50 (threshold dose) of 2.9 (1.7–4.6) and 1.6 (1.3–2.0) mg/kg i.v., whereas the threshold for NMDA-induced seizures was elevated only in doses, THRD50 of 24.1 (21.9–26.5) mg/kg i.v., which affected motor coordination in the rotating rod, ED50 14.6 (12.1–17.6) mg/kg. The doses of ZK200775 are 10 and 30 mg/kg (intravenously). Reduced muscle tone in hereditary spastic rats [1]. ZK200775 (3.0 but not 1.5 or 6.0 mg/kg) significantly reduced nicotine-induced (0.6 mg/kg) DA release in NACC and nicotine-stimulated LMA.ZK200775 (1.5, 3.0, 6.0 mg/kg) alone influenced neither DA release nor LMA. ZK200775 showed 34-fold selectivity for AMPA receptors compared to NMDA receptors and no affinity to nicotine receptors [2]. |
别名 | MPQX hydrate, ZK200775 (hydrate) |
分子量 | 427.27 |
分子式 | C14H17F3N3O7P |
CAS No. | 1255517-78-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (11.70 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3404 mL | 11.7022 mL | 23.4044 mL | 58.511 mL |
5 mM | 0.4681 mL | 2.3404 mL | 4.6809 mL | 11.7022 mL | |
10 mM | 0.234 mL | 1.1702 mL | 2.3404 mL | 5.8511 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fanapanel hydrate 1255517-78-2 Others ZK-200775 ZK200775 MPQX Hydrate MPQX hydrate Fanapanel Hydrate ZK 200775 ZK200775 (hydrate) Inhibitor inhibitor inhibit