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Cat. No. | Product Name | Target | Signaling Pathways |
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T41323 |
Dihomo-γ-Linolenic acid methyl ester
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Others | Others |
Dihomo-γ-Linolenic acid methyl ester 是 Dihomo-γ-Linolenic acid 的甲酯形式,Dihomo-γ-Linolenic acid 具有抗炎和抗增殖作用。 | |||
T41235 |
γ-Linolenic acid ethyl ester
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γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) 是一种白三烯 B 受体 4(LTB4)的拮抗剂,具有潜在的抗炎作用。 | |||
T35417 |
α-Linolenic Acid (sodium salt)
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α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation. | |||
T36410 |
9(E),11(E),13(E)-Octadecatrienoic Acid
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9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces a... | |||
T36170 |
A1-Phytoprostane-I
A1-Phytoprostane-I |
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A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants. There are two A1-phytoprostanes, both having the single ketone group on the ring structure. This isoform results from cyclization between carbons 9 and 13 of linolenic acid, as opposed to carbons 3 and 7 in A1-phytoprostane-II. A1-Phytoprostanes induce the expression of glutathione-S-transferase, increase phytoalexin biosynthesis, and trigger the expression of sever... | |||
T37976 |
13(S)-HOTrE(γ)
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13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. It is synthesized in human platelets, but its specific function is not known. | |||
T38046 |
Cholesteryl Homo-γ-Linolenate
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Cholesteryl homo-γ-linolenate is a cholesterol ester. It accumulates in the adrenal gland of rabbits fed a diet high in linolenic acid. Levels of cholesteryl homo-γ-linolenate are decreased and positively correlate with cognitive decline in HIV-infected humans. | |||
T37855 |
7-hydroxycoumarinyl-γ-Linolenate
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7-hydroxycoumarinyl-γ-Linolenate is a γ-linolenic acid ester of 7-hydroxycoumarin (umbelliferone) that behaves as a substrate for cPLA2. Hydrolysis of 7-hydroxycoumarinyl-γ-linolenate by phospholipase results in the release of the fluorescent compound 7-hydroxycoumarin which can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm). | |||
T37233 |
(±)14(15)-EpEDE
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8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be pro... | |||
T37395 |
13(S)-HpOTrE(γ)
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13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE. At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1. | |||
T40880 |
(±)-Jasmonic acid
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(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings. | |||
T37500 |
Etherolenic Acid
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Etherolenic acid is a divinyl ether oxylipin.1,2It is a metabolite of linolenic acid that is formed in plantsvia13-lipoxygenase-mediated formation of 13(S)-HpOTrE followed by conversion to the divinyl ether by divinyl ether synthase. 1.Grechkin, A.N., Fazliev, F.N., and Mukhtarova, L.S.The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: Detection of the novel divinyl ether oxylipinsFEBS Letters371159-162(1995) 2.Hamberg, M.Biosynthesis of new divinyl ether oxylipins in Ranunculus plant... | |||
T36773 |
12(S)-HETrE
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12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro. | |||
T37159 |
8(S)-HETrE
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8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE . | |||
T37865 |
9(S)-HOTrE
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9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE is predominantly localized in cellular ester lipids of Glechoma hederacea leaves and is partially released during artificial dehydration. The biological role of 9(S)-HOTrE in G. hederacea leaves is still undetermined, but it may play a role in natural senescence. 9(S)-HOTrE is an inhibitor of spore germination and germ tube elongation of rice blast fungus with ED50 valu... | |||
T37400 |
15(S)-HETrE
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15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid . It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE. | |||
T83761 |
12-oxo-9(Z)-Dodecenoic Acid
12-oxo-9-cis-Dodecenoic Acid,12-keto-9Z-Dodecenoic Acid |
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12-oxo-9(Z)-Dodecenoic acid 是一种 ω-oxoacid 和 ω-6 PUFA 亚麻酸及ω-3 PUFA α-亚麻酸的代谢产物。通过植物中的脂氧合酶产生的13-羟基过氧化物中间体,由过氧化物裂解酶形成。12-oxo-9(Z)-Dodecenoic acid (100 µM) 对植物病原真菌 P. parasitica 有活性。 | |||
T36099 |
Jacaric Acid
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Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju... | |||
T37867 |
9(S)-HpOTrE
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9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid. The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to oc... | |||
T37919 |
Prostaglandin F1α
PGF1α,Prostaglandin F1α |
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Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3] | |||
T37394 |
13(S)-HpOTrE
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13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.1 In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.[2],[3],[4] Treatment of to... | |||
T37257 |
13,14-dihydro-15-keto Prostaglandin D1
13,14-dihydro-15-keto Prostaglandin D1 |
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Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto Prostaglandin D1 (13,14-dihydro-15-keto PGD1) is the theoretical metabolite of PGD1 via the 15-hydroxy PG dehydrogenase metabolic pathway. No biological studies for this compound have been repo... | |||
T37396 |
13-epi-12-oxo Phytodienoic Acid
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13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and fr... | |||
T36887 |
8(E),10(E),12(Z)-Octadecatrienoic Acid
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8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4868 |
gamma-Linolenic acid
gamolenic acid,γ-Linolenic acid,γ-亚麻酸 |
Endogenous Metabolite | Metabolism |
gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6),18 碳 (18C-) 多不饱和脂肪酸 (PUFA),可以从人乳和植物种子油中提取。 | |||
T3P2904 |
α-Linolenic acid
Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸 |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸,人体无法合成,从种子油中分离得到。它可调节 PI3K/Akt 信号传导,影响血栓形成过程。它具有抗心律失常的特性,并且与心血管疾病和癌症等有关。 | |||
T21504 |
γ-Linolenic Acid methyl ester
Methyl gamma-linolenate,γ-亚麻酸甲酯 |
LTR | Immunology/Inflammation |
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。 | |||
TN2374 |
Methyl Linolenate
α-亚麻酸甲酯,Linolenic acid methyl ester,亚麻酸甲酯 |
Others | Others |
Methyl Linolenate (Linolenic acid methyl ester) 是一种多不饱和脂肪酸。 它用于研究不饱和脂肪酸氧化/过氧化的机制和预防。 | |||
TQ0262 |
Dihomo-γ-linolenic acid
Diroleuton,顺式-8,11,14-二十烷三烯酸甲酯,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989 |
Others | Others |
Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids. | |||
TN2372 |
Ethyl linolenate
亚麻酸乙酯,Linolenic acid ethyl ester |
Others | Others |
Linolenic acid ethyl ester is derived from bamboo leaves and perilla seeds. Has the effect of treating hyperlipidemia. | |||
T78472 |
Punicic acid
Trichosanic acid |
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Punicic acid为石榴籽油中存在的一种生物活性化合物,为共轭α-亚麻酸及ω-5多不饱和脂肪酸的异构体,其具备研究慢性疾病潜力。 | |||
TN5153 |
Torilin
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MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome |
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症,它可以减轻关节炎的严重程度,改变 dLN 或关节中的白细胞活化,并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成,IC(50)值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性,它可能通过抑制肿瘤侵袭来抑制肿瘤发生,逆转癌细胞的多药耐药性,它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。 |