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Search Results for " leukotriene b4 "

62

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14045	Leukotriene B4 LTB4,5(S),12(R)-DiHETE	Others	Others
	Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T37619	Leukotriene B4 Ethanolamide
	The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4...
T37618	Leukotriene B4 dimethyl amide Leukotriene B4 dimethyl amide
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
T37256	12-oxo Leukotriene B4 12-oxo Leukotriene B4
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give ...
T38087	20-hydroxy Leukotriene B4 20-hydroxy Leukotriene B4
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2...
T37970	12-epi Leukotriene B4 12-epi Leukotriene B4
	Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr...
T37260	14,15-dehydro Leukotriene B4 14,15-dehydro Leukotriene B4
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value ...
T73793	20-Carboxy-Leukotriene B4
	20-Carboxy-Leukotriene B4 (20-COOH LTB4) 是 Leukotriene B4 (LTB4) 的代谢物。20-Carboxy-Leukotriene B4 以高亲和力与 BLT1 受体结合。20-Carboxy-Leukotriene B4 抑制 LTB4 介导的中性粒细胞反应，迁移、脱粒、白三烯生物合成。
T72144	6-trans-12-epi-Leukotriene B4
	6-trans-12-epi-Leukotriene B4 是一种花生四烯酸代谢物，是一种有效的抗炎剂。
T15002	CP-105696 Pfizer 105696	LTR	Immunology/Inflammation
	CP-105696 是一种具有强效性和选择性白三烯 B4 (LTB4) 受体拮抗剂，可用于研究异体移植物排斥反应。
T77638	BIRM 271	Phospholipase; LTR	Immunology/Inflammation; Metabolism
	BIRM 271 是一种新型花生四烯酸释放抑制剂，可阻断白三烯B4和人中性粒细胞中的血小板活化因子生物合成。BIRM 271 和 BIRM 270 属于对映异构体，对白三烯B4 的产生有抑制作用，IC50 为40 nM。
T3715	Acebilustat 阿西鲁司特,CTX-4430	Aminopeptidase; LTR	Immunology/Inflammation; Metabolism
	Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂，可用于炎症研究。
T17191	Bunaprolast U66858	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Bunaprolast (U66858) 是一种新型有效的白三烯 B4 (LTB4) 抑制剂。Bunaprolast 具有氧化降解活性，对脂氧合酶 (lipoxygenase)和 TXB2 释放具有抑制作用。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T68119	Ontazolast BIRM-270	LTR	Immunology/Inflammation
	Ontazolast 是一种小分子白三烯B4受体（LTB4R）拮抗剂，可用于治疗免疫系统疾病和呼吸系统疾病。Ontazolast 是治疗哮喘的候选化合物。
T68108L	Moxilubant HCl Moxilubant hcl(146978-48-5 Free base)	LTR	Immunology/Inflammation
	Moxilubant HCl 是一种小分子白三烯 B4 受体 1（LTB4R）拮抗剂，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究银屑病和类风湿关节炎。
T28974	Ticolubant	Calcium Channel; LTR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ticolubant 是一种具有口服活性的白三烯 B4 拮抗剂，对人类中性粒细胞 LTB4 受体具有很高的亲和力（Ki = 0.78 nM），能阻断 LTB4 诱导的 Ca2+ 迁移，IC50 为 6.6±1.5 nM，并在小鼠皮肤炎症模型中显示出局部抗炎活性。
T22358	Etalocib LY293111,VML295	Apoptosis; Leukotriene Receptor; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。
T9878	Croconazole	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
T28667	SB 201146 SB-201146,SB201146
	SB 201146 is a leukotriene B4 antagonist with high affinity.
T28527	RG 14893
	RG 14893 is a antagonist of high-affinity leukotriene B4 receptor.
T27913	LY 292728 LY292728,LY-292728
	LY 292728 is a highly potent antagonist of leukotriene B4 receptor.
T27896	LY 213024 LY-213024,LY213024
	LY 213024 is an antagonist of leukotriene B4 receptor.
T15801	LY210073	Others	Others
	LY210073 is an antagonist of the Leukotriene B4 (LTB4) receptor (IC50: 6.2 nM).
T26809	BIIL 260 BIIL260,BIIL-260
	BIIL 260 is a leukotriene B4 (BLT1) receptor antagonist with anti-inflammatory activity.
T70477	SC 53228
	SC 53228 is a specific leukotriene B4 receptor antagonist.
T68418	Furodysinin lactone
	Furodysinin lactone is an agonist of human leukotriene B4 receptor.
T22526	BML-111 5(S),6(R)-7-trihydroxymethyl Heptanoate	Others	Others
	inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis
T27916	LY 306669 LY-306669,LY306669
	LY 306669 is an antagonist of leukotriene B4 receptor.
T28699	SC-41930 CGS 24115,SC41930,CGS24115
	SC-41930 is a potent and selective antagonist of leukotriene B4 receptor.
T28325	PD 127443 PD127443,PD-127443
	PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.
T34555	SC 45694 SC45694,SC-45694
	SC 45694 is a leukotriene B4 (LTB4) analog.
T27906	LY 25648 LY-25648,LY25648
	LY 25648 is an antagonist of leukotriene B4.
T23895	WF 11605 WF11605,WF-11605
	WF 11605 is an antagonist of leukotriene B4 produced by a fungus and is a specific antagonist of LTB4.
T25592	Labdane F2
	Labdane F2 is an antagonist of thromboxane B2 and leukotriene B4 isolated from the Spanish herb Sideritis javalambrensis.
T68314	DG-051
	DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.
T68831	Furodysinin
	Furodysinin is an agonist of human leukotriene B4 receptor.
T31042	CP-195543 UNII-YB1F0V77MK,CP 195543
	CP-195543 is an effective leukotriene B4 antagonist for the treatment of inflammatory diseases.
T15803	LY223982 SKF107324,CGS23131	Others	Others
	LY223982 is an effective and specific inhibitor of the leukotriene B4 receptor (IC50: 13.2 nM). It also can against [3H]LTB4 binding to LTB4 receptor.
T71221	CGS 21595
	CGS 21595 inhibits the formation of 5-hydroxyeicosatetraenoic acid and leukotriene B4; rapidly metabolized to CGS 19213.
T27815	Leucettamol A Leucettamine A
	Leucettamol A is a leukotriene B4 receptor antagonist isolated from the marine sponge Leucetta microraphis. It inhibits the formation of a complex composed of the ubiquitin E2 enzyme Ubc13 and Uev1A.
T16395	ONO4057 ONO-LB457	Leukotriene Receptor	GPCR/G Protein
	ONO4057 是一种具有有效性和口服活性的 Leukotriene B4 受体拮抗剂，其 IC50 值为 0.7±0.3 μM。 ONO4057 对大鼠同种异体移植的免疫抑制作用。
T10543	BIIL-260 hydrochloride	Others	Others
	BIIL-260 hydrochloride is a potent and long-acting orally active antagonist of leukotriene B4 (LTB4) receptor with anti-inflammatory activity. It has a high affinity to the LTB4 receptor on isolated human neutrophil cell membranes (Ki: 1.7 nM).
T26958	CAY10583 CAY 10583,CAY-10583
	CAY10583 is an agonist of leukotriene B4 receptor type 2 (BLT2). CAY10583 directly promotes keratinocyte migration and indirectly enhances fibroblast proliferation by increasing keratinocyte production of bFGF1 and TGF-β, leadng to accelerate wound closur
T37460	Lipoxin B4 Lipoxin B4
	Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T78678	LTB4 antagonist 3	Leukotriene Receptor	GPCR/G Protein
	LTB4 antagonist 3 (compound 24e)为一种具有抗炎活性的LTB4拮抗剂，其IC50为477 nM。
T27026	CJ-13,610 CJ 13610,CJ-13610	Lipoxygenase	Metabolism
	CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
T72625	LTB4 antagonist 1	Leukotriene Receptor	GPCR/G Protein
	LTB4 antagonist 1为甲酰胺化合物，高效拮抗白三烯B4 (LTB4)，IC50值为288 nM，呈现出明显的抗炎活性。
T68108	Moxilubant	LTR	Immunology/Inflammation
	Moxilubant 是一种小分子白三烯B4受体1（LTB4R）拮抗剂，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究银屑病和类风湿关节炎。
T38308	Lipoxin B4 methyl ester
	Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.

化合物

Leukotriene B4

Cat.No: T14045

Synonym: LTB4,5(S),12(R)-DiHETE

Target: Others

Leukotriene B4 Ethanolamide

Cat.No: T37619

Leukotriene B4 dimethyl amide

Cat.No: T37618

Synonym: Leukotriene B4 dimethyl amide

12-oxo Leukotriene B4

Cat.No: T37256

Synonym: 12-oxo Leukotriene B4

20-hydroxy Leukotriene B4

Cat.No: T38087

Synonym: 20-hydroxy Leukotriene B4

12-epi Leukotriene B4

Cat.No: T37970

Synonym: 12-epi Leukotriene B4

14,15-dehydro Leukotriene B4

Cat.No: T37260

Synonym: 14,15-dehydro Leukotriene B4

20-Carboxy-Leukotriene B4

Cat.No: T73793

6-trans-12-epi-Leukotriene B4

Cat.No: T72144

Cat.No: T15002

Synonym: Pfizer 105696

Target: LTR

Cat.No: T77638

Target: Phospholipase, LTR

Cat.No: T3715

Synonym: 阿西鲁司特,CTX-4430

Target: Aminopeptidase, LTR

Cat.No: T17191

Synonym: U66858

Target: Lipoxygenase, LTR

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T68119

Synonym: BIRM-270

Target: LTR

Cat.No: T68108L

Synonym: Moxilubant hcl(146978-48-5 Free base)

Target: LTR

Cat.No: T28974

Target: Calcium Channel, LTR

Cat.No: T22358

Synonym: LY293111,VML295

Target: Apoptosis, Leukotriene Receptor, LTR

Cat.No: T9878

Target: Lipoxygenase, LTR

Cat.No: T28667

Synonym: SB-201146,SB201146

Cat.No: T28527

Cat.No: T27913

Synonym: LY292728,LY-292728

Cat.No: T27896

Synonym: LY-213024,LY213024

Cat.No: T15801

Target: Others

Cat.No: T26809

Synonym: BIIL260,BIIL-260

Cat.No: T70477

Furodysinin lactone

Cat.No: T68418

Cat.No: T22526

Synonym: 5(S),6(R)-7-trihydroxymethyl Heptanoate

Target: Others

Cat.No: T27916

Synonym: LY-306669,LY306669

Cat.No: T28699

Synonym: CGS 24115,SC41930,CGS24115

Cat.No: T28325

Synonym: PD127443,PD-127443

Cat.No: T34555

Synonym: SC45694,SC-45694

Cat.No: T27906

Synonym: LY-25648,LY25648

Cat.No: T23895

Synonym: WF11605,WF-11605

Cat.No: T25592

Cat.No: T68314

Cat.No: T68831

Cat.No: T31042

Synonym: UNII-YB1F0V77MK,CP 195543

Cat.No: T15803

Synonym: SKF107324,CGS23131

Target: Others

Cat.No: T71221

Cat.No: T27815

Synonym: Leucettamine A

Cat.No: T16395

Synonym: ONO-LB457

Target: Leukotriene Receptor

BIIL-260 hydrochloride

Cat.No: T10543

Target: Others

Cat.No: T26958

Synonym: CAY 10583,CAY-10583

Cat.No: T37460

Synonym: Lipoxin B4

LTB4 antagonist 3

Cat.No: T78678

Target: Leukotriene Receptor

Cat.No: T27026

Synonym: CJ 13610,CJ-13610

Target: Lipoxygenase

LTB4 antagonist 1

Cat.No: T72625

Target: Leukotriene Receptor

Cat.No: T68108

Target: LTR

Lipoxin B4 methyl ester

Cat.No: T38308

Cat. No.	Product Name	Target	Signaling Pathways
T21504	γ-Linolenic Acid methyl ester Methyl gamma-linolenate,γ-亚麻酸甲酯	LTR	Immunology/Inflammation
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
T19791	Chamazulene BA2784,BA 2784,BA-2784,Dimethulene
	Chamazulene is an anti-inflammatory agent as well as an antioxidant-type inhibitor of leukotriene B4 formation.
T37972	12-OxoETE
	12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.
T36051	Lipoxin A4 脂氧素 A4,LXA4
	Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4] Analytical and biological comparisons of synth...
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

γ-Linolenic Acid methyl ester

Cat.No: T21504

Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯

Target: LTR

Cat.No: T19791

Synonym: BA2784,BA 2784,BA-2784,Dimethulene

Cat.No: T37972

Cat.No: T36051

Synonym: 脂氧素 A4,LXA4

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

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