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Search Results for " laci "

Targets Recommended: Others

26

抑制剂 & 化合物

12

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0035	Fulacimstat BAY1142524	Others	Others
	Fulacimstat (BAY1142524) 是可口服的糜酶抑制剂，能够作用于人糜酶(IC50:4 nM)和仓鼠糜酶(IC50:3 nM)。
T6914	Oclacitinib maleate PF-03394197 maleate,奥拉替尼马来酸盐,PF-03394197	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Oclacitinib maleate (PF-03394197 maleate) 是一种新型JAK 抑制剂，有效抑制JAK1，IC50为 10 nM。
T1439	Lacidipine SN-305,拉西地平,GX-1048,GR-43659X	Apoptosis; Calcium Channel; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。
T2012	Oclacitinib PF-03394197	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Oclacitinib (PF-03394197) 是一种有效的选择性 JAKs 抑制剂，IC50 为 10-99 nM；不抑制一组 38 种非 JAK 激酶 (IC50 > 1000 nM)。
T13202	Trilaciclib hydrochloride G1T28 hydrochloride	CDK	Cell Cycle/Checkpoint
	Trilaciclib hydrochloride (G1T28 hydrochloride) 是一种CDK4/6的抑制剂，对 CDK4 和 CDK6 的IC50值分别为 1 nM 和 4 nM。
T21113	N2-Acetylaciclovir Aciclovir EP Impurity F	Antibacterial	Microbiology/Virology
	N2-Acetylaciclovir (Aciclovir EP Impurity F) 是抗病毒化合物Aciclovir 的衍生物，具有选择性T 细胞免疫毒性。
T27400L	Ganaplacide phosphate Ganaplacide phosphate (1261113-96-5 Free base)	Others	Others
	Ganaplacide phosphate 对疟原虫症状性无性血期感染具有多阶段抗疟活性，并且能够在动物模型中预防传播和阻断感染。
T70002	Salacinol
	Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.
T13202L	Trilaciclib G1T28	CDK	Cell Cycle/Checkpoint
	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
T76894	Abelacimab
	Abelacimab (MAA868) 是一种全人源IgG1单克隆抗体，可高亲和力与FXI 的催化结构域结合并将其锁定在酶原构象中，从而防止其被 FXIIa 或凝血酶激活。Abelacimab 可用于血栓栓塞性疾病研究。
T25950	Phosalacine
	Phosalacine, isolated from Kitasatosporia phosalacinea, is a new herbicidal antibiotic that contains phosphinothricin.
T125160	Harmalacidine
	Harmalacidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125160。
T39103	Pafolacianine OTL 38
	Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker utilized for identifying ovarian cancer lesions during surgeries.
T78283	Caplacizumab ALX-0081,ALX-0681
	Caplacizumab (ALX-0681)为人源化抗血管性血友病因子(vWF)纳米抗体，具有抑制vWF介导的血小板粘附作用，可阻止微血栓进一步形成。该化合物在血栓性血小板减少性紫癜（TTP）研究中应用。
T1087L	Valaciclovir
	Valacyclovir (Valaciclovir) 是一种具有口服活性的抗病毒药物，用于抑制单纯疱疹，带状疱疹和疱疹 B。Valacyclovir 抑制 HSV-1W (50=2.9 μg/ml)。Valacyclovir 是 Aciclovir 的前药。
T71450	Ilacirnon sodium
	Ilacirnon sodium is a potent CCR2 antagonist that may be useful in the treatment of renal diseases including Focal Segmental Glomerulosclerosis and Diabetic Nephropathy.
T23617	Aclacinomycin Aclacinomycins,Siwenmycin
	Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer.
T34815	Tetcyclacis Tetracyclacis,Ken BYO,Ken-BYO,KenBYO
	Tetcyclacis is a plant growth retardant.
T14781	Brilacidin PMX 30063	Others	Others
	Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.
T75246	Cyclacillin
	Cyclacillin (Wy-4508)，一种口服氨基青霉素类抗生素，展示对革兰氏阳性及阴性病原体的广泛抗菌活性。
T32524	Laciniatin
	Laciniatin belongs to the class of organic compounds named flavonols.
T62677	Ganaplacide hydrochloride
	Ganaplacide (KAF156) hydrochloride 是一种首创的、口服具有活力的咪唑哌嗪类抗疟药 (antimalarial)。Ganaplacide hydrochloride 对多种疟原虫（包括耐药寄生虫）有作用。Ganaplacide hydrochloride 对无性和有性血液阶段以及肝脏阶段均具有杀虫效果。
T38608	Brilacidin tetrahydrochloride PMX 30063 tetrahydrochloride
	Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is a defensin mimetic antibiotic compound, exhibiting potent anti-infective antimicrobial activity against a range of bacteria. It demonstrates MIC90 values of 1 μg/mL and 8 μg/mL against the Gram-positive bacteria Streptococcus pneumoniae and Streptococcus viridans, respectively. Additionally, it has a MIC90 value of 8 μg/mL for the Gram-negative bacteria Haemophilus influenzae and a MIC90 value of 4 μg/mL for Pseudomonas aeruginosa.
T27400	Ganaplacide KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156
	Ganaplacide is an antimalarials with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. KAF156 showed antimalarial activity without evident safety concerns in a small number of adults with uncompli
T25674	Leualacin
	Leualacin is a novel calcium blocker from Hapsidospora irregularis.
T124640	Fallacinol
	Fallacinol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124640。

化合物

Cat.No: TQ0035

Synonym: BAY1142524

Target: Others

Oclacitinib maleate

Cat.No: T6914

Synonym: PF-03394197 maleate,奥拉替尼马来酸盐,PF-03394197

Target: Tyrosine Kinases, JAK

Cat.No: T1439

Synonym: SN-305,拉西地平,GX-1048,GR-43659X

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species

Cat.No: T2012

Synonym: PF-03394197

Target: JAK

Trilaciclib hydrochloride

Cat.No: T13202

Synonym: G1T28 hydrochloride

Target: CDK

N2-Acetylaciclovir

Cat.No: T21113

Synonym: Aciclovir EP Impurity F

Target: Antibacterial

Ganaplacide phosphate

Cat.No: T27400L

Synonym: Ganaplacide phosphate (1261113-96-5 Free base)

Target: Others

Cat.No: T70002

Cat.No: T13202L

Synonym: G1T28

Target: CDK

Cat.No: T76894

Cat.No: T25950

Cat.No: T125160

Cat.No: T39103

Synonym: OTL 38

Cat.No: T78283

Synonym: ALX-0081,ALX-0681

Cat.No: T1087L

Ilacirnon sodium

Cat.No: T71450

Cat.No: T23617

Synonym: Aclacinomycins,Siwenmycin

Cat.No: T34815

Synonym: Tetracyclacis,Ken BYO,Ken-BYO,KenBYO

Cat.No: T14781

Synonym: PMX 30063

Target: Others

Cat.No: T75246

Cat.No: T32524

Ganaplacide hydrochloride

Cat.No: T62677

Brilacidin tetrahydrochloride

Cat.No: T38608

Synonym: PMX 30063 tetrahydrochloride

Cat.No: T27400

Synonym: KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156

Cat.No: T25674

Cat.No: T124640

Cat. No.	Product Name	Target	Signaling Pathways
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T21502	Aclacinomycin A
	Aclacinomycin A 在生命科学相关研究中具有广泛的应用。
T78498	Oxyphyllacinol
	Oxyphyllacinol为Alpinia oxyphylla果实中提取的一种天然化合物。
T3767	Polygalacic acid Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸	MMP; AChR; AChE	Neuroscience; Proteases/Proteasome
	Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜，可抑制 MMP 表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。它可以用于骨关节炎相关研究。
T80953	Tremulacin
	Tremulacin为Populus树皮及其叶子中的关键糖苷组分。
TN6437	Polygalacin D2
	Polygalacin D2 may have antimicrobial activity.
TN5330	Lacinilene C 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one
	Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through pot
T75528	Malacidin A
	Malacidin A 是一种钙依赖性抗生素。Malacidin A 对许多耐药病原体，特别是革兰氏阳性菌具有高度活性。
T10238	Aclacinomycin A hydrochloride 盐酸阿柔比星,Aclarubicin hydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.
T40298	Phallacidin
	Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.
T75529	Malacidin B
	Malacidin B 是一种大环脂肽抗生素，以钙依赖的方式发挥抗菌活性。
T32525	Laciniatoside V
	Laciniatoside V is a metabolite.

天然产物

Cat.No: TN2091

Target: Apoptosis, IAP

Aclacinomycin A

Cat.No: T21502

Cat.No: T78498

Polygalacic acid

Cat.No: T3767

Synonym: Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸

Target: MMP, AChR, AChE

Cat.No: T80953

Cat.No: TN6437

Cat.No: TN5330

Synonym: 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one

Cat.No: T75528

Aclacinomycin A hydrochloride

Cat.No: T10238

Synonym: 盐酸阿柔比星,Aclarubicin hydrochloride

Target: Proteasome

Cat.No: T40298

Cat.No: T75529

Laciniatoside V

Cat.No: T32525

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01030	TFPI Protein, Human, Recombinant (His) TFPI1,tissue factor pathway inhibitor (lipoprotein-associate...	Human	HEK293 Cells
	TFPI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1.
TMPK-00194	TFPI Protein, Human, Recombinant (His & Avi) LACI,EPI,TFPI,convertin,TFI,TFPI1	Human	HEK293 Cells
	Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1.
TMPK-00195	TFPI Protein, Human, Recombinant (His & Avi), Biotinylated convertin,TFI,LACI,EPI,TFPI,TFPI1	Human	HEK293 Cells
	Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1.
TMPY-00928	TFPI Protein, Mouse, Recombinant (His) AW552122,A630013F22Rik,tissue factor pathway inhibitor (lipo...	Mouse	HEK293 Cells
	TFPI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is O54819-1.
TMPY-05179	TFPI Protein, Human, Recombinant (His), Biotinylated TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ...	Human	HEK293 Cells
	TFPI Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1.
TMPH-03211	TFPI Protein, Rabbit, Recombinant (His)	Rabbit	HEK293 Cells
	Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P19761.
TMPH-03210	TFPI Protein, Rabbit, Recombinant (E. coli, His)	Rabbit	E. coli
	Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.8 kDa and the accession number is P19761.

重组蛋白

TFPI Protein, Human, Recombinant (His)

Cat.No: TMPY-01030

Species: Human

Expression System: HEK293 Cells

TFPI Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00194

Species: Human

Expression System: HEK293 Cells

TFPI Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00195

Species: Human

Expression System: HEK293 Cells

TFPI Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00928

Species: Mouse

Expression System: HEK293 Cells

TFPI Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05179

Species: Human

Expression System: HEK293 Cells

TFPI Protein, Rabbit, Recombinant (His)

Cat.No: TMPH-03211

Species: Rabbit

Expression System: HEK293 Cells

TFPI Protein, Rabbit, Recombinant (E. coli, His)

Cat.No: TMPH-03210

Species: Rabbit

Expression System: E. coli

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