133
9
Cat. No. | Product Name | Target | Signaling Pathways |
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T22465 |
1,2-Distearoyl-sn-glycerol
|
Others | Others |
1,2-Distearoyl-sn-glycerol 是一种内标物,可用于分离和鉴定 1,2-diacyl-sn-glycerol (DAG) 的分子种类。 | |||
T6335 |
Tie2 kinase inhibitor 1
Tie2 kinase inhibitor |
Tie-2 | Tyrosine Kinase/Adaptors |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。 | |||
T19658 |
Enflurane
NSC115944,Ethrane,NSC-115944,恩氟烷,Efrane,NSC 115944 |
Others | Others |
Enflurane (Efrane) 是一种挥发性麻醉剂,是 Chara australis 高电导 Ca2+ 激活的 K+ 通道的有效抑制剂。 安氟醚是通过顶空气相色谱-质谱法监测卤化挥发性麻醉剂的内标。 它可以快速调整麻醉深度,而脉搏或呼吸频率几乎没有变化。 | |||
T21230 |
Butyl decanoate
Butyl caprate,AI3-33573,Decanoic acid, butyl ester |
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Butyl decanoate could substitute hazardous compounds used in tissue processing and dewaxing, along with other compounds without impairing the diagnostic value of the tissue sections. It is also used as an internal standard to calculate the acid concentrat | |||
T22214 |
1,5,5-Trimethylhydantoin
1,5,5-三甲基海因,TMH |
Others | Others |
1,5,5-Trimethylhydantoin (TMH) 是非同位素内标化合物的一种。 | |||
T35618 |
D-Fructose-13C6
D-果糖 13C6 |
Others | Others |
D-Fructose-13C6 可用作通过 GC-或 LC-MS 定量 D-果糖的内标。 | |||
T73712 |
Metformin-d6 hydrochloride
1,1-Dimethylbiguanide-d6 hydrochloride |
AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物,可用于研究 Metformin 在体内的代谢,常作为Metformin的内标。 | |||
T77493 |
Murlentamab
3C23K,GM102 |
Others | Others |
Murlentamab (GM102) 是一种人源化抗 AMHRII 抗体。Murlentama 具有潜在的抗肿瘤活性,可诱导巨噬细胞介导的抗体依赖的细胞介导的细胞毒性作用 (ADCC)。Murl可通过募,集、活化T细胞激发促炎和抗肿瘤内环境。Murlentama 通过促进幼稚的巨噬细胞定向,促进肿瘤相关巨噬细胞 (TAM) 重编程来发挥抗肿瘤活性。 | |||
T9428 |
HM43239
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
HM43239 是一种具有口服活性和选择性 FLT3抑制剂,IC50值为 1.1 nM (FLT3 野生型)、1.8 nM (FLT3 ITD 突变型) 和 1.0 nM (FLT3 D835Y 突变型)。HM43239 作为可逆的 I 型抑制剂直接抑制 FLT3 的激酶活性,并调节 p-STAT5, p-ERK SYK, JAK1/2 和 TAK1。HM43239 抑制白血病细胞的增殖并诱导其凋亡 (apoptosis)。 | |||
T34027 |
PhIP-D3
PhIP D3 |
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PhIP-D3 is a deuterated internal standard for PhIP. | |||
T68949 |
Chlorocitalopram hydrobromide
|
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Chlorocitalopram hydrobromide is an internal standard of Citalopram -- an inhibitor of serotonin (5-HT) uptake. | |||
T15552 |
Iferanserin
S-MPEC |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential for internal hemorrhoid disease treatment. | |||
T38182 |
C17 Sphingomyelin (d18:1/17:0)
C17 Sphingomyelin (d18:1/17:0) |
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C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin. | |||
T37365 |
7-hydroxy Coumarin sulfate (potassium salt)
|
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7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS. | |||
T20616 |
Coumachlor
G-23133,Ratilan,G23133,Tomorin,G 23133 |
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Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage. | |||
T19849 |
2-PADQZ
2PADQZ,2-PADQZ |
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DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B. | |||
T12555 |
PROTAC FLT-3 degrader 1
|
Others; PROTACs | Others; PROTAC |
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity. | |||
T30935 |
ci-IP3/PM
|
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CI-IP3 /PM is a cell-permeable caged inositol triphosphate that promotes the release of Ca2+ from internal storage under UV photolysis. | |||
T72001 |
CB096
|
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CB096 is a novel inhibitor of RAN translation. specifically binds to a repeating 1 × 1 GG internal loop structure, 5'CGG/3'GGC, that is formed when r(G4C2)exp folds, also acting as a potent vasorelaxant agent, showing antihypertensive effect. | |||
T38185 |
C2 3'-sulfo Galactosylceramide (d18:1/2:0)
C2 3'-sulfo Galactosylceramide (d18:1/2:0) |
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C2 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma. | |||
T70350 |
Caspofungin
|
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Caspofungin is a cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic mycoses. | |||
T38190 |
Tyr-α-CGRP (rat) (trifluoroacetate salt)
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Tyr-α-CGRP (rat) is an N-terminally tyrosinated analog of the neuropeptide α-CGRP that induces a fall in resting tension of isolated opossum internal anal sphincter (IAS) with an EC50 value of 178 nM. | |||
T36437 |
Sphinganine (d17:0)
Sphinganine (d17:0) |
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Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods. | |||
T19377 |
Ioxilan
|
Others | Others |
Ioxilan is a low-osmolar, nonionic, and tri-iodinated diagnostic contrast agent used for excretory urography and contrast-enhanced computed tomographic (CECT) imaging of the head and body. Intravascularly injected causes opacification of vessels, allowing for radiographic visualization of internal structures until significant hemodilution occurs. | |||
T37327 |
Prostaglandin F2α 1,15-lactone
Prostaglandin F2α 1,15-lactone |
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PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective. | |||
T36217 |
19-hydroxy Cholesterol
|
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19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.[1] | |||
T37438 |
C17 Globotriaosylceramide (d18:1/17:0)
C17 Globotriaosylceramide (d18:1/17:0) |
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C17 Globotriaosylceramide is a sphingolipid that has been used as an internal standard for the quantification of globotriaosylceramides in plasma and urine from patients with Fabry disease by GC-MS. | |||
T38056 |
Cholesteryl Arachidate
Cholesterol Arachidate |
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Cholesteryl arachidate is a cholesterol ester that has been found in human meibum.[1][2] It has been used as an internal standard for the quantification of fatty acids in B. napus.[3] | |||
T39818 |
Desmorpholinyl Quizartinib-PEG2-COOH
Desmorpholinyl Quizartinib-PEG2-COOH |
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Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM. | |||
T61415 | FLT3/ITD-IN-1 | ||
FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144.1 nM, respectively. Moreover, FLT3/ITD-IN-1 shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1]. | |||
T38037 |
Caffeic Acid-13C3
Caffeic Acid-13C3 |
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Caffeic acid-13C3 is an isotopically enriched form of caffeic acid that is intended for use as an internal standard for the quantification of caffeic acid by GC- or LC-MS. Caffeic acid is an inhibitor of 5-LO , with IC50 values of 3.7-72 μM, and 12-LO, with IC50 values of 5.1-30 μM. | |||
T35515 |
3-Acetyldeoxy Nivalenol-13C17
3-Acetyldeoxy Nivalenol-13C17 |
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3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami... | |||
T40419 |
IRES-C11
IRES-C11 |
c-Myc | Cell Cycle/Checkpoint |
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53. | |||
T76161 | Bacterial α-Amylase | ||
Bacterialα-Amylase 通过催化淀粉的α-1,4-糖苷键的水解反应,生成低分子量产物,例如葡萄糖和麦芽糖,广泛应用于生化研究中。 | |||
T37147 |
5'-O-DMT-N4-Ac-dC
5'-O-DMT-N4-Ac-dC |
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5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7) is a deoxynucleoside utilized in the synthesis of dodecyl phosphoramidite. Dodecyl phosphoramidite serves as a crucial precursor for dod-DNA production, which is amphiphilic DNA comprising dodecyl phosphotriester linkages and featuring an internal hydrophobic region[1][2]. | |||
T36383 |
L-Thyroxine-13C9,15N
L-Thyroxine-13C9,15N |
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L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode... | |||
T76385 |
[Tyr8] Bradykinin
|
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[Tyr8] Bradykinin 是B2激肽受体 (B2kinin receptor) 的激动剂,能刺激ERK1/2磷酸化,并可作为内标。 | |||
T37058 |
D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
|
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D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell. | |||
T35521 |
Aflatoxin G2-13C17
Aflatoxin G2-13C17 |
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Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/kg) but is non-toxic to rats when administered at a dose of 200 mg/kg.2 1.Bennett, J.W., and Klich, M.MycotoxinsClin. Microbiol. Rev.16(3)497-516(2003) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins a... | |||
T37344 |
5,6-dimethyl-2-Thiouracil
|
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5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 |1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma... | |||
T37682 |
3-hydroxy Tridecanoic Acid
|
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3-hydroxy Tridecanoic acid is a 13-carbon saturated fatty acid found in bacterial lipopolysaccharides (LPS). It can be used as an internal standard to detect markers of microorganisms in complex samples, including 3-hydroxy fatty acids found in LPS-containing bacteria and muramic acid found in bacterial cell wall peptidoglycan. | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
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5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | |||
T37178 |
Norhyodeoxycholic Acid
|
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Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of δ5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3 |1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon ... | |||
T36537 |
Nitrofurantoin-13C3
Nitrofurantoin-13C3 |
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Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca... | |||
T35697 |
Lauric Acid-13C
|
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Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2 | |||
T78353 |
alpha-2,6-Sialyltransferase (Pd26ST)
|
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alpha-2,6-Sialyltransferase (Pd26ST) 能够催化末端和内部半乳糖及N-乙酰半乳糖胺的唾液酸化,形成末端α2,6-唾液酸苷。 | |||
T76153 |
PNGase F
|
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PNGase F 是一种糖苷酶,可催化寡糖中内部糖苷键的裂解。PNGase F 可从糖蛋白中去除几乎所有的 N-连接寡糖。 | |||
T71326 |
1,3,7-Trimethyluric Acid-d9
|
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1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes. | |||
T35503 |
(±)-5,7-Dimethyltocol
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(±)-5,7-Dimethyltocol is a form of tocopherol. It has similar antioxidant activity to α-tocol, but lower activity than γ-tocol, in antioxidant assays using menhaden oil or squalene as substrates. It also increases microviscosity of rat liver liposomes containing phosphatidylcholine (PC) by 70.6% when used at a molar ratio of 0.2 to PC. (±)-Dimethyltocol has been used as an internal standard for the quantification of 5,7-tocol, α- and γ-tocopherol, and α- and γ-tocopheryl quinone by HPLC. | |||
T71893 |
Clobetasol Propionate-d5
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Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T8067 |
Methyl Nonadecanoate
Nonadecanoic Acid methyl ester,正十九酸甲酯 |
Others | Others |
Methyl Nonadecanoate (Nonadecanoic Acid methyl ester)是一种内标物,能够用于生物柴油中脂肪酸甲酯含量的测定。 | |||
T8027 |
2-Ethylbutyric Acid
|
Others | Others |
2-Ethylbutyric acid 是一种内标物,可用于粪便的 VFA 分析标准的校准方法。 | |||
T19615 |
α-Amylase
|
Amylase | Metabolism |
α-Amylase 是一种能够催化淀粉中 α-1,4-糖苷键水解的水解酶,使淀粉产生葡萄糖、麦芽糖等产物。 | |||
TN1136 |
Procyanidin A1
原花青素 A1,Proanthocyanidin A1,原花色素A1 |
LDL; Calcium Channel; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism |
Procyanidin A1 (Proanthocyanidin A1) 是一种原花青素二聚体,具有抗过敏作用,可抑制蛋白激酶 C 激活下游脱粒或 RBL-213 细胞内部储存的 Ca2+流入。 | |||
T5917 |
2-Hydroxy-6-methoxybenzoic acid
6-甲氧基水杨酸,2-羟基-6-甲氧基苯甲酸,6-Methoxysalicylic acid |
Others | Others |
2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) 可用于动物血浆中乙酸水杨酸及其主要代谢物水杨酸含量的测定,表现出较好的抗缓解疼痛活性。 | |||
T1353 |
DL-Mevalonolactone
甲瓦龙酸内酯,Mevalonolactone |
Others; Endogenous Metabolite | Metabolism; Others |
DL-Mevalonolactone (Mevalonolactone),一种人内源性代谢物,是甲羟戊酸的 δ-lactone 形式,甲羟戊酸途径的一个前体。它能够降低大脑中线粒体膜电位(∆Ψm),Ca2+的保留能力和 NAD (P) H 的含量 , 而且还诱导线粒体肿胀。 | |||
T78473 |
Sphingosine (d17:1)
C17 Sphingosine |
||
Sphingosine (d17:1) (C17 Sphingosine)是一种存在于人类皮肤中的17碳鞘脂,可被鞘氨醇激酶的磷酸化。Sphingosine C-17作为内标可用于进行鞘脂类化合物的光谱分析。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T38179 |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)
C16 3'-sulfo Galactosylceramide (d18:1/16:0) |
Others | Others |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物,在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。 |