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49
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16570 |
Pralnacasan
VX-740,HMR 3480 |
Others | Others |
Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a | |||
T10447 |
BAA473
|
Others | Others |
BAA473 是胆汁酸类似物,是一种强效的吡喃类炎症小体激活剂。BAA473可通过激活髓样和肠上皮细胞中的炎症小体来诱导白细胞介素( IL-18 )的分泌。 | |||
T62950 | IRAK4-IN-18 | ||
IRAK4-IN-18 是一种白介素 1 受体相关激酶 4 (IRAK4) 的有效抑制剂 (IC50: 15 nM)。IRAK4-IN-18 能够抑制 THP 和 DC 细胞中 LPS 诱导的 IL23 产生,阻断关节炎模型大鼠的关节炎发展。IRAK4-IN-18 可用于研究关节炎疾病。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00277 |
IL-18 Protein, Human, Recombinant
IGIF,IL-18,IL1F4,IL-1g,Interleukin 18<... |
Human | E. coli |
IL-18 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is Q14116-1. | |||
TMPY-03951 |
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc)
interleukin 18 receptor 1 |
Cynomolgus | HEK293 Cells |
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9. | |||
TMPY-02824 |
IL-18R alpha Protein, Rat, Recombinant (hFc)
interleukin 18 receptor 1 |
Rat | HEK293 Cells |
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2. | |||
TMPY-03273 |
IL-18 Protein, Mouse, Recombinant
interleukin 18,白细胞介素,白介素,Il-18,Ig... |
Mouse | E. coli |
IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1. | |||
TMPY-01928 |
IL-18 Protein, Rhesus, Recombinant (His)
白细胞介素,interleukin 18,白介素 |
Rhesus | E. coli |
IL-18 Protein, Rhesus, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.7 kDa and the accession number is Q9BGI5. | |||
TMPY-00846 |
IL-18BP Protein, Human, Recombinant (His)
interleukin 18 binding protein,IL18 |
Human | HEK293 Cells |
IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2. | |||
TMPY-03102 |
IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (hFc)
interleukin 18 receptor accessory protein,... |
Rhesus | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.4 kDa and the accession number is XP_001108108.1. | |||
TMPY-05492 |
IL-18BP Protein, Human, Recombinant (aa 1-192, hFc)
interleukin 18 binding protein,IL18 |
Human | HEK293 Cells |
IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1. | |||
TMPY-05782 |
IL-18R alpha Protein, Mouse, Recombinant (mFc)
Il18rα,Il1rrp,interleukin 18 rece... |
Mouse | HEK293 Cells |
IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098. | |||
TMPY-01376 |
IL-18R alpha Protein, Mouse, Recombinant (His)
Il1rrp,Il18ralpha,interleukin 18 ... |
Mouse | HEK293 Cells |
IL-18R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is Q61098. | |||
TMPY-05491 |
IL-18R alpha Protein, Human, Recombinant (hFc)
CDw218a,interleukin 18 receptor 1... |
Human | HEK293 Cells |
IL-18R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q13478. | |||
TMPY-01111 |
IL-18BP Protein, Mouse, Recombinant (His)
IL-18BP,MC54L,interleukin 18 bind... |
Mouse | HEK293 Cells |
IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9. | |||
TMPY-01219 |
IL-18R alpha Protein, Human, Recombinant (His)
CDw218a,interleukin 18 receptor 1... |
Human | HEK293 Cells |
IL-18R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q13478. | |||
TMPY-01446 |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (His)
IL-18Rbeta,CD218b,IL-18R β/IL- |
Human | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is O95256-1. | |||
TMPY-00345 |
IL-18R alpha Protein, Canine, Recombinant (His)
interleukin 18 receptor 1 |
Canine | HEK293 Cells |
IL-18R alpha Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa. | |||
TMPY-00509 |
IL-18R alpha Protein, Cynomolgus, Recombinant (His)
interleukin 18 receptor 1 |
Cynomolgus | HEK293 Cells |
IL-18R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is F7H8F9. | |||
TMPY-03901 |
IL-18R alpha Protein, Canine, Recombinant (hFc)
interleukin 18 receptor 1 |
Canine | HEK293 Cells |
IL-18R alpha Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.9 kDa and the accession number is XP_854199.2. | |||
TMPY-03911 |
IL-18R alpha Protein, Rat, Recombinant (His)
interleukin 18 receptor 1 |
Rat | HEK293 Cells |
IL-18R alpha Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.9 kDa and the accession number is D3ZRM2. | |||
TMPK-00492 |
IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
Igifbp,Interleukin-18-binding protein,IL-<... |
Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombi... | |||
TMPY-00984 |
IL-18R alpha Protein, Mouse, Recombinant (His & hFc)
Il18rα,interleukin 18 receptor 1,... |
Mouse | HEK293 Cells |
IL-18R alpha Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 63.5 kDa and the accession number is Q61098. | |||
TMPY-06750 |
IL-18R beta/IL-18RAP Protein, Rabbit, Recombinant (His)
interleukin 18 receptor accessory protein,... |
Rabbit | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.22 kDa and the accession number is G1SQ92. | |||
TMPY-06761 |
IL-18R beta/IL-18RAP Protein, Rat, Recombinant (His)
interleukin 18 receptor accessory protein,... |
Rat | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.28 kDa and the accession number is A0A0G2K2K7. | |||
TMPK-00491 |
IL-18BP Protein, Cynomolgus, Recombinant (His)
Igifbp,Interleukin-18-binding protein,IL-<... |
Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Cynomolgus, Recombinant (His) is expressed i... | |||
TMPJ-00072 |
IL-18BPd Protein, Mouse, Recombinant (hFc)
Interleukin 18 Binding Protein Isoform d,I... |
Mouse | HEK293 Cells |
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the bin... | |||
TMPY-03103 |
IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (His)
interleukin 18 receptor accessory protein,... |
Rhesus | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.85 kDa and the accession number is XP_001108108.1. | |||
TMPY-03381 |
IL-18 Protein, Human, Recombinant (GST)
IL-18,IL-1g,白介素,IGIF,白细胞介素,IL1F4,interleukin |
Human | E. coli |
IL-18 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 48.6 kDa and the accession number is Q14116. | |||
TMPJ-00344 |
IL-18RAP Protein, Human, Recombinant (hFc & His)
IL-1R accessory protein-like,Interleukin-18 |
Human | HEK293 Cells |
IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease. | |||
TMPJ-00074 |
IL-18BP Protein, Human, Recombinant (hFc)
Interleukin-18-binding protein,Tadekinig-a... |
Human | HEK293 Cells |
Interleukin-18-binding protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peri... | |||
TMPY-06578 |
IL-18R alpha Protein, Human, Recombinant (hFc & Avi), Biotinylated
IL18RA,CDw218a,CD218a,IL1RRP,IL-1... |
Human | HEK293 Cells |
IL-18R alpha Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 64.30 kDa and the accession number is NP_003846.1. | |||
TMPY-06897 |
IL-18R alpha Protein, Human, Recombinant (His), Biotinylated
IL18RA,interleukin 18 receptor 1,... |
Human | HEK293 Cells |
IL-18R alpha Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.21 kDa and the accession number is NP_003846.1. | |||
TMPJ-00070 |
IL-18 Protein, Human, Recombinant (His)
GIF,IL-1 γ,白细胞介素,Iboctadekin,Interleukin-18 |
Human | HEK293 Cells |
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After... | |||
TMPY-00844 |
IL-17RD Protein, Human, Recombinant (His)
IL-17RD,interleukin 17 receptor D,HH18,IL1... |
Human | HEK293 Cells |
IL-17RD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.5 kDa and the accession number is Q8NFM7-1. | |||
TMPK-00076 |
IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated
白介素,IL-18,白细胞介素,IL18,IL-1F4,IL-1g,IL1F4,IL... |
Human | E. coli |
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. | |||
TMPJ-01056 |
IL-18 Protein, Mouse, Recombinant (His)
Interferon γ-inducing factor,Interleukin-1 gamma,Ig... |
Mouse | E. coli |
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins... | |||
TMPY-00609 |
IL-18R beta/IL-18RAP Protein, Mouse, Recombinant (His)
interleukin 18 receptor accessory protein,... |
Mouse | Baculovirus Insect Cells |
IL-18R beta/IL-18RAP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 40.1 kDa and the accession number is Q0VBK3. | |||
TMPY-06316 |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (hFc & Avi), Biotinylated
IL-18Rbeta,IL-18R β/IL-18RAP,IL-1... |
Human | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 67.04 kDa and the accession number is NP_003844.1. | |||
TMPK-00661 |
IL-22 Protein, Cynomolgus, Recombinant (His)
TIFIL-23,IL-22,IL-D110,IL-TIF,TIFa,Interleukin-22,C... |
Cynomolgus | HEK293 Cells |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 17.69 kDa and the accession number is G7PHZ7. | |||
TMPY-01200 |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (hFc)
IL-1R-7,IL-1R7,interleukin 18 receptor acc... |
Human | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.2 kDa and the accession number is O95256-1. | |||
TMPY-06312 |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (His & Avi), Biotinylated
ACPL,CDw218b,IL-18RAcP,IL-18R-β,I... |
Human | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.76 kDa and the accession number is NP_003844.1. | |||
TMPK-01194 |
IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated
IL-22,Cytokine Zcyto18,白细胞介素,IL-TIF,白介素,Interle... |
Mouse | E. coli |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 19.7 kDa and the accession number i... | |||
TMPK-00316 |
IL-18R alpha Protein, Human, Recombinant (His & Avi)
CD218a,IL-18 R1,IL1RRP,IL-18Ra,IL... |
Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPK-00317 |
IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated
IL-18 R α,IL-1 R5,IL18Ra,IL-18Ra,... |
Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPK-00512 |
IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)
IL18R1,IL-1 Rrp,CD218a,IL18Ra,IL-... |
Cynomolgus | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPK-00082 |
IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated
Igifbp,IL-18BP,IL-18BPA |
Human | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated... | |||
TMPY-02597 |
IL-37 Protein, Human, Recombinant
FIL1Z,IL-37,白细胞介素,IL37,IL1F7,IL-1RP1,FIL1(ζ),IL1RP1,FIL1,白介素... |
Human | E. coli |
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression i... | |||
TMPK-00161 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
Interleukin-1 beta,IL-1 β,IL-1β,IL1F2,IL-1BETA,... |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ... | |||
TMPK-00515 |
IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)
Interleukin-1 β,IL-1 beta,IL1B,IL1F2,IL-1BETA,IL-1β... |
Cynomolgus | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p... | |||
TMPK-00162 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated
IL-1 β,IL-1β,IL-1 β/IL-1F2,IL-1 beta,IL1B,Interleukin |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C... | |||
TMPJ-00789 |
Flagellin Protein, Salmonella Typhimurium, Recombinant
flaF,Phase 1-I flagellin,Flagellin,fliC,hag |
Salmonella typhimurium | E. coli |
Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin is used as an effective systemic or mucosal adjuvant to stimulate the immune system. Flagellin is an agonist of Toll-like receptor 5 (TLR5), a pattern recognition receptor (PRR) of the innate immune system expressed on the basolateral surface of intestinal epithelial cells and o... |