IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,430 | 现货 | ||
200 μg | ¥ 4,310 | 5日内发货 |
生物活性 | Measured by its binding ability in a functional ELISA. Immobilized IL18BP Protein, Mouse, (His Tag) at 2 μg/mL (100 μL/well) can bind IL-18 Protein, Mouse Biotinylated, the EC50 of Biotinylated Mouse IL-18 is 25-80 μg/mL. |
产品描述 | IL-18BP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.4 kDa and the accession number is Q9Z0M9. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | C-His |
蛋白编号 | Q9Z0M9 |
别名 | IL-18BP, MC54L, interleukin 18 binding protein, Igifbp |
蛋白构建 | Mouse IL18BP (NP_034661.1) (Met 1-Ala 193) precursor was expressed with the polyhistide tag at the C-terminus. |
蛋白纯度 |
> 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
|
分子量 | 19.4 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases. |
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IL-18BP Protein, Mouse, Recombinant (His) IL-18BP MC54L interleukin 18 binding protein Igifbp recombinant recombinant-proteins proteins protein