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代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
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搜索结果

Search Results for " il-19 "
Targets Recommended: Interleukin

13

抑制剂 & 化合物

2

天然产物

21

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T9911 Tocilizumab

Interleukin Immunology/Inflammation
Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，能够阻碍 IL-6 与 IL-6R 的结合，进而抑制经典和反式信号。它可用于研究类风湿性关节炎，对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T76978 Siltuximab

CNTO-328

 IL Receptor Immunology/Inflammation
Siltuximab（CNTO-328） 是一种靶向 IL-6 且具有抗肿瘤活性的单克隆抗体，可用于研究巨大淋巴结增生症 (MCD) 和 COVID-19。
T36534 SDZ 224-015

SDZ 224015

 IL Receptor; Caspase Apoptosis; Immunology/Inflammation; Proteases/Proteasome
SDZ 224-015 是白细胞介素-1β（IL-1β）转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性，可减少角叉菜胶诱导的大鼠爪子水肿。
T0097 MRT67307

MRT67307 HCl

 IκB/IKK; Autophagy Autophagy; NF-κB
MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T77174 Efmarodocokin alfa

Efmarodocokin alfa为人IL-22与IgG4可结晶片段的融合蛋白，具有激活IL-22信号的功能。该化学物质主要用于重症COVID-19肺炎的研究。
T78175 JAK-IN-25

JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
JAK-IN-25（化合物19）是一种高效的JAK抑制剂，对TYK2、JAK1、JAK2和JAK3的IC50值分别为6 nM、21 nM、8 nM、1051 nM。该化合物还能抑制人全血中IL-12（HEB IL-12），IC50为28 nM，显示其在癌症研究中的潜在应用价值。
T73372 GNE-2256

GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4Ki=1.4 nM ; IL-6IC50=190 nM)。
T36885 BMSpep-57 hydrochloride

BMSpep-57 hydrochloride, a potent macrocyclic peptide, competitively inhibits PD-1/PD-L1 interaction, exhibiting an IC50 value of 7.68 nM. It binds to PD-L1 with dissociation constants (Kds) of 19 nM and 19.88 nM as determined by MST and SPR assays, respectively. This compound enhances T cell functionality by promoting IL-2 production in PBMCs[1].
T35468 (±)19(20)-EDP Ethanolamide

(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...
T79449 Antileishmanial agent-19

Parasite Microbiology/Virology
Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂，其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶，并干预宿主PI3K/Akt/CREB轴，从而抑制IL-10的分泌。此外，Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程，并在感染的动物体内显著减少寄生虫负担。
T76675 Clazakizumab

Clazakizumab是一种具有高亲和力和特异性的单克隆抗体，针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外，Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。
T39106 BMSpep-57

BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 with dissociation constants (Kd) of 19 nM and 19.88 nM in MicroScale Thermophoresis (MST) and Surface Plasmon Resonance (SPR) assays, respectively. This compound enhances T cell functionality by promoting Interleukin-2 (IL-2) production within Peripheral Blood Mononuclear Cells (PBM...
T23028 MRT67307 HCl (1190378-57-4 free base)

MRT67307 HCl

 Others Others
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...

化合物

Tocilizumab
Cat.No: T9911
Synonym:
Target: Interleukin
Siltuximab
Cat.No: T76978
Synonym: CNTO-328
Target: IL Receptor
SDZ 224-015
Cat.No: T36534
Synonym: SDZ 224015
Target: IL Receptor, Caspase
MRT67307
Cat.No: T0097
Synonym: MRT67307 HCl
Target: IκB/IKK, Autophagy
Efmarodocokin alfa
Cat.No: T77174
Synonym:
Target:
JAK-IN-25
Cat.No: T78175
Synonym:
Target: JAK
GNE-2256
Cat.No: T73372
Synonym:
Target:
BMSpep-57 hydrochloride
Cat.No: T36885
Synonym:
Target:
(±)19(20)-EDP Ethanolamide
Cat.No: T35468
Synonym:
Target:
Antileishmanial agent-19
Cat.No: T79449
Synonym:
Target: Parasite
Clazakizumab
Cat.No: T76675
Synonym:
Target:
BMSpep-57
Cat.No: T39106
Synonym:
Target:
MRT67307 HCl (1190378-57-4 free base)
Cat.No: T23028
Synonym: MRT67307 HCl
Target: Others
Cat. No. Product Name Target Signaling Pathways
T40660 Kansuinine B

IL Receptor; SARS-CoV Immunology/Inflammation; Microbiology/Virology
Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性，可用于 COVID-19 研究。
TN1154 Nepetin

6-Methoxyluteolin,泽兰黄酮,6-甲氧基藤黄菌素

 Calcium Channel; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
Nepetin (6-Methoxyluteolin) 是一种分离自Eupatorium ballotaefoliumHBK 中的天然类黄酮，具有有效的抗炎作用。它在 ARPE-19 细胞中能够抑制IL-6(IC50:4.43 μM) 、IL-8 (IC50:43.42 μM) 、MCP-1 (IC50:4.17 μM) 的分泌。

天然产物

Kansuinine B
Cat.No: T40660
Synonym:
Target: IL Receptor, SARS-CoV
Nepetin
Cat.No: TN1154
Synonym: 6-Methoxyluteolin,泽兰黄酮,6-甲氧基藤黄菌素
Target: Calcium Channel, Histamine Receptor
Species：
Human (18)
Mouse (2)
Cynomolgus (1)
Expression System：
HEK293 Cells (18)
E. coli (2)
Baculovirus Insect Cells (1)
Tag：
C-His (6)
C-6xHis (3)
C-His-Avi (3)
C-hFc (3)
C-Avi (1)
C-hFc-Avi (1)
C-mFc (1)
His, Avi (1)
His, hFc (1)
Tag Free (1)
Cat. No. Product Name Species Expression System
TMPY-00406 IL-23 Protein, Human, Recombinant (His)

IL23P19,P19,SGRF,IL-23,<...

 Human HEK293 Cells
IL-23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-05247 IL-23 Protein, Human, Recombinant (His), Biotinylated

IL23P19,IL23,P19,IL<...

 Human HEK293 Cells
IL-23 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-05648 IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated

IL23,IL-23,白细胞介素,白介素,P19,IL

Human HEK293 Cells
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPK-01229 IL-19 Protein, Human, Recombinant (hFc)

NG.1,IL-10C,Interleukin-19,白介素,白细胞介素,MDA1,...

 Human HEK293 Cells
Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected.IL-19 is correlated with the severity of acute myocardial infarction, which may be a new idea for the clinical treatment of myocardial infarction.
TMPY-00493 IL-19 Protein, Human, Recombinant (His)

interleukin 19,Interleukin-19,IL-...

 Human Baculovirus Insect Cells
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
TMPY-04874 IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

IL-23A,IL-23,interleukin 23, alpha subunit...

 Human HEK293 Cells
IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.
TMPY-00841 IL-13RA2 Protein, Human, Recombinant (His)

CT19,interleukin 13 receptor, alpha 2,CD213A2,inter...

 Human HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
TMPY-04987 IL-23 P19/IL23A Protein, Human, Recombinant (mFc)

IL-23,interleukin 23, alpha subunit p19,SG...

 Human HEK293 Cells
IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7.
TMPK-01169 IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated

Interleukin-23 subunit α,Interleukin-23 subunit alpha,IL...

 Mouse HEK293 Cells
The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma.
TMPK-00272 IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated

AI882074,IL-13 R alpha 1,IL-13 R α1,CD213A...

 Human HEK293 Cells
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2. IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HE...
TMPK-00273 IL-13Ra1 Protein, Human, Recombinant (hFc)

NR4,CD213A1,IL-13 R alpha 1,CT19,IL

Human HEK293 Cells
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2. IL-13Ra1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells...
TMPY-00842 IL-13RA2 Protein, Human, Recombinant (His & hFc)

CT19,IL13BP,interleukin 13 receptor, alpha...

 Human HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q14627.
TMPY-05334 IL-13RA2 Protein, Human, Recombinant (His), Biotinylated

CT19,IL-13R,IL13BP,interleukin 13...

 Human HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
TMPK-00242 IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, His & Avi), Biotinylated

IL3RAY,IL-3R subunit alpha,IL-3 R...

 Human HEK293 Cells
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
TMPJ-00244 IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated

IL-3R subunit α,IL-3RA,Interleukin-3 recep...

 Human HEK293 Cells
IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 80-100 KDa and the accession number is P26951.
TMPY-00846 IL-18BP Protein, Human, Recombinant (His)

interleukin 18 binding protein,IL18BPa

 Human HEK293 Cells
IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.
TMPJ-00161 IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated

Hematopoietin-1,IL-1 α,IL-1 Alpha,白细胞介素,In...

 Human E. coli
IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated is expressed in E. coli expression system with C-Avi tag. The predicted molecular weight is 19 KDa and the accession number is P01583.
TMPJ-00633 IL-17F Protein, Cynomolgus, Recombinant (His)

IL17F,Cytokine ML-1,IL-17F,Interleukin-17F

 Cynomolgus HEK293 Cells
IL-17F Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19-22 KDa and the accession number is G7P4V0.
TMPJ-00078 IL-17C Protein, Human, Recombinant (His)

CX2,IL-17C,interleukin-17C,IL17C,IL

Human HEK293 Cells
IL-17C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is Q9P0M4.
TMPJ-00573 IL-17F Protein, Human, Recombinant (His)

IL17F,IL-17F,Cytokine ML-1,Interleukin-17F

 Human HEK293 Cells
IL-17F Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is AAH70124.1.
TMPJ-00909 IL-1RA Protein, Mouse, Recombinant

IL-1RN,IRAP,Interleukin-1 Receptor Antagonist Prote...

 Mouse E. coli
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and I...

重组蛋白

IL-23 Protein, Human, Recombinant (His)
Cat.No: TMPY-00406
Species: Human
Expression System: HEK293 Cells
IL-23 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05247
Species: Human
Expression System: HEK293 Cells
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05648
Species: Human
Expression System: HEK293 Cells
IL-19 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-01229
Species: Human
Expression System: HEK293 Cells
IL-19 Protein, Human, Recombinant (His)
Cat.No: TMPY-00493
Species: Human
Expression System: Baculovirus Insect Cells
IL-23 P19/IL23A Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04874
Species: Human
Expression System: HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00841
Species: Human
Expression System: HEK293 Cells
IL-23 P19/IL23A Protein, Human, Recombinant (mFc)
Cat.No: TMPY-04987
Species: Human
Expression System: HEK293 Cells
IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01169
Species: Mouse
Expression System: HEK293 Cells
IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00272
Species: Human
Expression System: HEK293 Cells
IL-13Ra1 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00273
Species: Human
Expression System: HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00842
Species: Human
Expression System: HEK293 Cells
IL-13RA2 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05334
Species: Human
Expression System: HEK293 Cells
IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, His & Avi), Biotinylated
Cat.No: TMPK-00242
Species: Human
Expression System: HEK293 Cells
IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated
Cat.No: TMPJ-00244
Species: Human
Expression System: HEK293 Cells
IL-18BP Protein, Human, Recombinant (His)
Cat.No: TMPY-00846
Species: Human
Expression System: HEK293 Cells
IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated
Cat.No: TMPJ-00161
Species: Human
Expression System: E. coli
IL-17F Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00633
Species: Cynomolgus
Expression System: HEK293 Cells
IL-17C Protein, Human, Recombinant (His)
Cat.No: TMPJ-00078
Species: Human
Expression System: HEK293 Cells
IL-17F Protein, Human, Recombinant (His)
Cat.No: TMPJ-00573
Species: Human
Expression System: HEK293 Cells
IL-1RA Protein, Mouse, Recombinant
Cat.No: TMPJ-00909
Species: Mouse
Expression System: E. coli
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