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Search Results for " hexokinase "

16

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T69625	Benitrobenrazide Hexokinase 2 inhibitor 1	Hexokinase	Metabolism
	Benitrobenrazide (Hexokinase 2 inhibitor 1) 是一种新型可口服的己糖激酶 2 (HK2) 抑制剂，具有抗癌抗肿瘤活性，通过靶向糖酵解来阻断癌细胞生长。Benitrobenrazide 抑制 SW1990 和 SW480 异种移植模型中的肿瘤生长，可用于研究癌症。
T5882	3-Bromopyruvic acid Hexokinase II Inhibitor II, 3-BP,3-溴丙酮酸,Bromopyruvic acid	Apoptosis; Hexokinase; Autophagy	Apoptosis; Autophagy; Metabolism
	3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂，是针对肝癌细胞的一种抗肿瘤剂。
T76111	Hexokinase (ScHEX1)
	Hexokinase(ScHEX1) 是一种糖酵解酶己糖激酶，收到 N-乙酰氨基葡萄糖的抑制。N-乙酰氨基葡萄糖对 Hexokinase(ScHEX1) 的抑制导致其与线粒体外膜分离，而导致 NLRP3炎症小体激活。
TQ0055	AMG-3969	Glucokinase	Metabolism
	AMG-3969 是一种葡萄糖激酶-葡糖激酶调节蛋白相互作用的干扰物，IC50=为4 nM。
T16479	PF-04937319	Others; Glucokinase	Metabolism; Others
	PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T3104	Globalagliatin LY2608204	Glucokinase	Metabolism
	Globalagliatin (LY2608204) 是一种葡萄糖激酶 (GK) 活化剂，EC50=42 nM。
T3312	AM-2394 AM2394	Glucokinase	Metabolism
	AM-2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK)，EC50=60 nM。
T26712	AZD-1656 AZD 1656	Glucokinase	Metabolism
	AZD-1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
T12056	MK-0941 free base	Glucokinase	Metabolism
	MK-0941 free base 是一种口服具有活力的葡糖激酶抑制剂，在葡萄糖浓度为 2.5 和 10 mM 的条件下，对重组人 glucokinase 的EC50值分别为 240 和 65 nM。它具有较强的降血糖特性，是研究 2 型糖尿病的候选药物。
T15159	Dorzagliatin HMS5552	Glucokinase	Metabolism
	Dorzagliatin (HMS5552) 是双重作用的葡萄糖激酶 (glucokinase;GK) 激活剂，可改善 2 型糖尿病的血糖控制，提高胰腺 β 细胞功能。
T0239	Lonidamine AF1890,氯尼达明,DICA,Diclondazolic Acid	Apoptosis; Hexokinase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Lonidamine (Diclondazolic Acid) 是一种抗肿瘤药物，是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂，同时也抑制线粒体复合物 II。
T15654	Ketohexokinase inhibitor 1 PF-06835919	Others	Others
	Ketohexokinase inhibitor 1 是一种酮己糖激酶抑制剂（对 KHK-C 和 KHK-A 的 IC50：分别为 8.4 nM 和 66 nM）。
T72092	2-Deoxy-D-glucose 6-phosphate disodium
	2-Deoxy-D-glucose 6-phosphate disodium，一种2-Deoxy-D-glucose的衍生物，是通过己糖激酶在哺乳动物细胞中作用于2-DG而生成。该化合物是葡萄糖代谢的竞争性抑制剂，主要通过抑制己糖激酶从而阻碍糖酵解过程。
T83889	C-02
	C-02是一种由巨噬细胞抑制剂Lonidamine和Cereblon配体Thalidomide组成的蛋白酶体靶向嵌合体（PROTAC）。在20 µM浓度下使用时，可诱导786-O和PANC-1细胞中的Hexokinase 2降解。C-02对786-O、4T1、PANC-1、HGC-27和MCF-7癌细胞具有细胞毒性（IC50分别为34.07、5.08、31.53、6.11和21.65 µM）。同时，20 µM浓度下减少4T1细胞的细胞外酸化率（ECAR）和氧气消耗率（OCR），表明其抑制糖酵解和引起线粒体损伤。在体内，C-02（50 mg/kg）能减少4T1小鼠乳腺癌模型的肿瘤体积，并诱导肿瘤内细胞因子积累和细胞焦亡。
T35683	2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6
	2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste...
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...

化合物

Benitrobenrazide

Cat.No: T69625

Synonym: Hexokinase 2 inhibitor 1

Target: Hexokinase

3-Bromopyruvic acid

Cat.No: T5882

Synonym: Hexokinase II Inhibitor II, 3-BP,3-溴丙酮酸,Bromopyruvic acid

Target: Apoptosis, Hexokinase, Autophagy

Hexokinase (ScHEX1)

Cat.No: T76111

Cat.No: TQ0055

Target: Glucokinase

Cat.No: T16479

Target: Others, Glucokinase

Cat.No: T3104

Synonym: LY2608204

Target: Glucokinase

Cat.No: T3312

Synonym: AM2394

Target: Glucokinase

Cat.No: T26712

Synonym: AZD 1656

Target: Glucokinase

MK-0941 free base

Cat.No: T12056

Target: Glucokinase

Cat.No: T15159

Synonym: HMS5552

Target: Glucokinase

Cat.No: T0239

Synonym: AF1890,氯尼达明,DICA,Diclondazolic Acid

Target: Apoptosis, Hexokinase, Mitochondrial Metabolism

Ketohexokinase inhibitor 1

Cat.No: T15654

Synonym: PF-06835919

Target: Others

2-Deoxy-D-glucose 6-phosphate disodium

Cat.No: T72092

Cat.No: T83889

2-deoxy-D-Glucose-13C6

Cat.No: T35683

Synonym: 2-deoxy-D-Glucose-13C6

Paromomycin, sulfate (1:1)

Cat.No: T65387

Cat. No.	Product Name	Target	Signaling Pathways
T19500	Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸	Glucokinase; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	trans-Palmitelaidic Acid (trans-Palmitoleic acid) 是palmitoleic acid 的反式异构体。Palmitoleic acid 是血清和组织中最丰富的脂肪酸之一。
T6742	2-Deoxy-D-glucose 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,D-2-脱氧葡萄糖,NSC 15193,2-DG,2-脱氧-D-葡萄糖	Apoptosis; Hexokinase; HSV	Apoptosis; Metabolism; Microbiology/Virology
	2-Deoxy-D-glucose (2-DG) 是葡萄糖的类似物，是一种糖酵解抑制剂。2-Deoxy-D-glucose 具有抗病毒活性，还具有抑制细胞增殖、诱导细胞凋亡的活性。
T4900	(±)-Methyl Jasmonate (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others; Endogenous Metabolite	Metabolism; Others
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。
T5113	L-GLUCOSE L-葡萄糖,L-(-)-Glucose	Others	Others
	L-Glucose (L-(-)-Glucose) 是一种 D-glucose 的对映体，可促进食物的摄取。
T4726	D-Glucose 6-phosphate sodium G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。
T5069	D-Glucose 6-phosphate potassium salt	Others	Others
	在细胞中，当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中通过磷酸葡萄糖变位酶转化葡萄糖 1-磷酸时，会产生D-glucose 6-phosphate (G6P)。 G6P 位于糖酵解和戊糖磷酸途径的起点。当血糖水平高时，它也可以作为糖原储存。

天然产物

Palmitelaidic Acid

Cat.No: T19500

Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸

Target: Glucokinase, AMPK, PPAR

2-Deoxy-D-glucose

Cat.No: T6742

Synonym: 2-Deoxy-D-arabino-hexose,2-deoxyglucose,D-Arabino-2-deoxyhexose,Ba 2758,D-2-脱氧葡萄糖,NSC 15193,2-DG,2-脱氧-D-葡萄糖

Target: Apoptosis, Hexokinase, HSV

(±)-Methyl Jasmonate

Cat.No: T4900

Synonym: (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

Cat.No: T5113

Synonym: L-葡萄糖,L-(-)-Glucose

Target: Others

D-Glucose 6-phosphate sodium

Cat.No: T4726

Synonym: G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate

Target: Others, Endogenous Metabolite

D-Glucose 6-phosphate potassium salt

Cat.No: T5069

Target: Others

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