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34

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6531	Heparin sodium salt 肝素钠,Sodium heparinate,Heparin sodium	Factor Xa; Thrombin; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Heparin sodium salt (Sodium heparinate) 是一种抗凝剂，可与抗凝血酶 III 可逆地结合，使凝血酶因子 IIa 和 Xa 的失活速度加快，显着抑制外泌体-细胞相互作用。
TP1153L	Fibronectin Adhesion-promoting Peptide acetate Fibronectin Adhesion-promoting Peptide acetate(125720-21-0 free base),Heparin Binding Peptide acetate	Others	Others
	Fibronectin Adhesion-promoting Peptide acetate (Heparin Binding Peptide acetate)(125720-21-0 free base) 是在纤连蛋白的羧基末端肝素结合结构域中发现的肝素结合氨基酸序列之一。
T4076	Fondaparinux sodium Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra	Factor Xa	Metabolism
	Fondaparinux sodium (SR-90107A) 是抗凝血酶依赖性的 factor Xa 抑制剂。
TP2255	heparin cofactor II precursor fragment [Homo sapiens]	Others	Others
	Heparin cofactor II precursor fragment [Homo sapiens] is a peptide with the sequence H2N-Tyr-Glu-Ile-Thr-Thr-Ile-His-Asn-Leu-Phe-Arg-OH, MW=1406.58.
TP2256	heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]	Others	Others
	Heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] is a peptide with the sequence H2N-Phe-Thr-Val-Asp-Arg- Pro-Phe-Leu-Phe-Leu-Ile-Tyr-Glu-His-Arg-OH, MW=1953.25.
T64262	Heparin Lithium salt
	Heparin Lithium salt 是一种抗凝剂，能够可逆的结合抗凝血酶III (ATIII)。Heparin Lithium salt 明显阻碍外泌体-细胞相互作用。
TP1153	Fibronectin Adhesion-promoting Peptide Heparin Binding Peptide
	Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.
TP1152	Fibronectin Adhesion-promoting Peptide TFA Heparin Binding Peptide TFA
	Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into lar
T40711	H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride	Others	Others
	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation.
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
T10820L1	Ciraparantag acetate Ciraparantag acetate(1438492-26-2 Free base)	Others	Others
	Ciraparantag acetate 是一种抗凝逆转剂，是一种小分子，专门设计用于通过电荷-电荷相互作用与普通肝素和低分子量肝素非共价结合。它显示出与直接口服抗凝剂 (DOAC) 相似的结合特性。
T0155	Argatroban MCI-9038,阿加曲班,MD-805,Argipidine	Thrombin	Proteases/Proteasome
	Argatroban (MCI-9038) 是一种选择性的凝血酶抑制剂。
T22246	Argatroban Monohydrate 阿加曲班一水合物,阿加曲班	Thrombin	Proteases/Proteasome
	Argatroban Monohydrate 是一种 thrombin 选择性抑制剂。
T13720	Hexadimethrine bromide 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,海美溴铵,聚凝胺,Polybrene	Others	Others
	Hexadimethrine bromide (1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide) 是阳离子聚合物，常用于提高逆转录病毒载体介导的基因转移效率。
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T24531	NIC
	NIC is an inhibitor of host invasion. It is also an inhibitor of VEGF binding to immobilized heparin.
TP1959	PM 102
	Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).
T10820	Ciraparantag PER977	Others	Others
	Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin, low-molecular-weight heparin, and certain direct oral anticoagulants.
T11341	FXIa-IN-1	Others	Others
	FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
T31522	Dipropyl sulfone
	Dipropyl sulfone may function as an enhancer of heparin absorption in the intestine.
T37568	4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)
	4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase defi...
T10820L	Ciraparantag TFA PER977 TFA	Others	Others
	Ciraparantag TFA is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin, low-molecular-weight heparin, and certain direct oral anticoagulants.
T36292	NSC 12
	NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 μM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 μM, preventing them from forming HSPG/FGF/FGFR ternary complexes. NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduc...
T16377	Odiparcil SB-424323	Thrombin	Proteases/Proteasome
	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.
T82890	bFGF (119-126)
	bFGF (119-126) 为具备生物活性的肽段，对应人类、牛(119-126)、小鼠、大鼠(118-125)以及肝素结合生长因子2(118-125)的相应残基。该肽能够抑制bFGF受体的二聚化及其激活作用。
T36111	L-Iduronic acid sodium salt
	L-Iduronic acid sodium salt 是一种单糖，是肝素、硫酸乙酰肝素和硫酸皮肤素等糖胺聚糖 (GAG) 的重要成分。
T73751	Lepirudin
	Lepirudin为高效的不可逆凝血酶抑制剂，同时是重组水蛭素，主要在肝素诱导的血小板减少症（HIT）中发挥抗凝作用。
T83672	TTAPE-Me 1,1,2,2-tetrakis[4-(2-Trimethylammonioethoxy)-phenylethene
	TTAPE-Me是一种聚集诱导发光(AIE)荧光团。它被用于检测阴离子磷脂，包括心磷脂、磷脂酰甘油(PG)和磷脂酰丝氨酸(PS)、核酸，以及阴离子多糖肝素。
T8926	Salcaprozate sodium 8-(2-羟基苯甲酰胺基)辛酸钠,SNAC	Others	Others
	Salcaprozate sodium (SNAC) 是口服吸收促进剂，有作为口服形式的肝素和胰岛素递送剂的潜力。它可提高非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。
T39066	H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride,H-D-Phe-Pip-Arg-pNA hydrochloride
	H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, mimics the N-terminal segment of the A alpha chain of fibrinogen, the native substrate of thrombin. It displays specificity towards thrombin and is employed for quantifying antithrombin-heparin cofactor (AT-III). The utilization of H-D-Phe-Pip-Arg-pNA hydrochloride in the AT-III assay enables a sensitive, accurate, and straightforward measurement process.
T36370	4-Methylumbelliferyl-α-L-Iduronide (free acid)
	4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an...
T36714	Sucrose octasulfate (potassium salt)
	Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...

化合物

Heparin sodium salt

Cat.No: T6531

Synonym: 肝素钠,Sodium heparinate,Heparin sodium

Target: Factor Xa, Thrombin, Autophagy

Fibronectin Adhesion-promoting Peptide acetate

Cat.No: TP1153L

Synonym: Fibronectin Adhesion-promoting Peptide acetate(125720-21-0 free base),Heparin Binding Peptide acetate

Target: Others

Fondaparinux sodium

Cat.No: T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra

Target: Factor Xa

heparin cofactor II precursor fragment [Homo sapiens]

Cat.No: TP2255

Target: Others

heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]

Cat.No: TP2256

Target: Others

Heparin Lithium salt

Cat.No: T64262

Fibronectin Adhesion-promoting Peptide

Cat.No: TP1153

Synonym: Heparin Binding Peptide

Fibronectin Adhesion-promoting Peptide TFA

Cat.No: TP1152

Synonym: Heparin Binding Peptide TFA

H-D-Phe-Pip-Arg-pNA dihydrochloride

Cat.No: T40711

Synonym: S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride

Target: Others

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

Ciraparantag acetate

Cat.No: T10820L1

Synonym: Ciraparantag acetate(1438492-26-2 Free base)

Target: Others

Cat.No: T0155

Synonym: MCI-9038,阿加曲班,MD-805,Argipidine

Target: Thrombin

Argatroban Monohydrate

Cat.No: T22246

Synonym: 阿加曲班一水合物,阿加曲班

Target: Thrombin

Hexadimethrine bromide

Cat.No: T13720

Synonym: 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,海美溴铵,聚凝胺,Polybrene

Target: Others

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Cat.No: T68002

Target: Thrombin

Cat.No: T24531

Cat.No: TP1959

Cat.No: T10820

Synonym: PER977

Target: Others

Cat.No: T11341

Target: Others

Fondaparinux free base

Cat.No: T71532

Dipropyl sulfone

Cat.No: T31522

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)

Cat.No: T37568

Ciraparantag TFA

Cat.No: T10820L

Synonym: PER977 TFA

Target: Others

Cat.No: T36292

Cat.No: T16377

Synonym: SB-424323

Target: Thrombin

Cat.No: T82890

L-Iduronic acid sodium salt

Cat.No: T36111

Cat.No: T73751

Cat.No: T83672

Synonym: 1,1,2,2-tetrakis[4-(2-Trimethylammonioethoxy)-phenylethene

Salcaprozate sodium

Cat.No: T8926

Synonym: 8-(2-羟基苯甲酰胺基)辛酸钠,SNAC

Target: Others

H-D-Phe-Pip-Arg-pNA hydrochloride

Cat.No: T39066

Synonym: S-2238 hydrochloride,H-D-Phe-Pip-Arg-pNA hydrochloride

4-Methylumbelliferyl-α-L-Iduronide (free acid)

Cat.No: T36370

Sucrose octasulfate (potassium salt)

Cat.No: T36714

Cat. No.	Product Name	Target	Signaling Pathways
T20654	Heparin Certoparin,Bemiparin,Dalteparin,Adomiparin	Thrombin; Endogenous Metabolite; Antibacterial; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Heparin (Adomiparin) 是硫酸粘多糖，常在临床医学上当抗凝剂使用。Heparin 在体内实验中显示出部分抗炎活性。
T41031	Protamine sulfate	Thrombin	Proteases/Proteasome
	Protamine sulfate是一种多阳离子肽类，作为一种抗肝素剂。该化合物能中和肝素的抗凝作用并增强脂质介导的基因转移。
Fr16605	Lupinine 鲁冰花,羽扇豆碱	AChR; AChE	Neuroscience
	Lupinine 是一种能够抵消乙醇麻醉的生物碱。 Lupinine 是一种 AChE 和 BChE 抑制剂和潜在的 CD69 激活剂，存在于 Loranthus、Calia 和 Lupinus 物种中。它还可以抑制肝素。
T2O2721	L-Cysteine Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine	Endogenous Metabolite	Metabolism
	L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中，对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分，在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用，也是氨基酸牛磺酸的制造所必需的。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。

天然产物

Cat.No: T20654

Synonym: Certoparin,Bemiparin,Dalteparin,Adomiparin

Target: Thrombin, Endogenous Metabolite, Antibacterial, Autophagy

Protamine sulfate

Cat.No: T41031

Target: Thrombin

Cat.No: Fr16605

Synonym: 鲁冰花,羽扇豆碱

Target: AChR, AChE

Cat.No: T2O2721

Synonym: Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine

Target: Endogenous Metabolite

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

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