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12

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22833	H-9 dihydrochloride	EGFR; 5-HT Receptor; PKA	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	H-9 dihydrochloride 是一种具有有效性的蛋白激酶（ PKA）抑制剂。H-9 Dihydrochloride 在低浓度下显著降低 5-HT 的兴奋性反应。H-9 Dihydrochloride 会对咽部活动产生影响。H-9 Dihydrochloride 对 EGF (表皮生长因子)依赖的上皮细胞系的信号转导和细胞生长有抑制作用。
T2517	SCH900776 MK 8776,MK-8776	Chk; CDK	Cell Cycle/Checkpoint
	SCH900776 (MK-8776) 是一种靶向细胞周期检查点激酶 1(Chk1) 的抑制剂，IC50值为 3 nM。它比对 CDK2 和 Chk2 的选择性分别高 50 和 500 倍，具有潜在的放射增敏和化学增敏活性。
T3700	SCH900776 (S-isomer) MK-8776 S-isomer,SCH900776 S-isomer	Chk; CDK	Cell Cycle/Checkpoint
	SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。
T70932	L6H9
	L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fibrosis markers such as TGF-β and collagen IV.
T9901A-018	S2H97
	S2H97 是一种中和抗体，能够广泛对抗乙型冠状病毒支系 B 下的新冠肺炎与 SARS 等病毒。
T22721	DH97 DH 97	Others	Others
	MT2 melatonin receptor antagonist
T34833	TH9402 TH 9402,TH-9402,Xanthylium
	TH9402 is a dibrominated rhodamine derivative and potent photosensitizer and useful in photodynamic therapy. TH9402 eradicates multiple myeloma (MM) and BC cell lines, while sparing more than 50% of normal pluripotential blood stem cells from healthy volu
T16764	RN-18	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	RN-18是 HIV-1 病毒感染因子的一种拮抗剂。
T31195	Dalcotidine KU 1257,KU-1257	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dalcotidine (KU 1257) 是一种新型组胺H2受体拮抗剂，具有组胺H9受体拮抗活性和抗分泌作用，与豚鼠大脑皮层结合的Ki 值为0.040 对分离性豚鼠右心房组胺诱导的正变时反应的拮抗作用的KB 值为0.041。Dalcotidine 提高了溃疡愈合的质量，可能有助于降低溃疡的复发率和复发率。
T77094	Navivumab
	Navivumab (CT-P23)是针对甲型流感病毒(influenza A virus) HA血凝素的单克隆抗体。该药物通过结合HA2蛋白的茎融合结构域，能中和H1、H2、H5及H9型甲型流感病毒。
T68667	Oxanosine
	Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al...
T37874	Feglymycin
	Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 μg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 μM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 μM). It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 μM) and to CD4+ SupT1 T cells by 74.5% when us...

化合物

H-9 dihydrochloride

Cat.No: T22833

Target: EGFR, 5-HT Receptor, PKA

Cat.No: T2517

Synonym: MK 8776,MK-8776

Target: Chk, CDK

SCH900776 (S-isomer)

Cat.No: T3700

Synonym: MK-8776 S-isomer,SCH900776 S-isomer

Target: Chk, CDK

Cat.No: T70932

Cat.No: T9901A-018

Cat.No: T22721

Synonym: DH 97

Target: Others

Cat.No: T34833

Synonym: TH 9402,TH-9402,Xanthylium

Cat.No: T16764

Target: HIV Protease

Cat.No: T31195

Synonym: KU 1257,KU-1257

Target: Histamine Receptor

Cat.No: T77094

Cat.No: T68667

Cat.No: T37874

Cat. No.	Product Name	Target	Signaling Pathways
TN2283	Tripterifordin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tripterifordin 在 H9 淋巴细胞中显示出抗 HIV 复制活性，EC50值为 3100 nM。
TN4646	Neotripterifordin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
TN4934	Salaspermic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
T75692	Hypoglaunine D
	Hypoglaunine D 是 Triptonine B 的类似物，是一种抗HIV 的化合物，Hypoglaunine D 抑制 H9 淋巴细胞中HIV 病毒复制的EC50值为 22 μg/ml。
TN1194	16beta,17-Dihydroxy-ent-kaurane-19-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosi
TN3152	6-Acetonyldihydrochelerythrine	ERK; BCL; Akt; HIV Protease; PPAR; p53	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is

天然产物

Cat.No: TN2283

Target: HIV Protease

Neotripterifordin

Cat.No: TN4646

Target: HIV Protease

Salaspermic acid

Cat.No: TN4934

Target: HIV Protease

Cat.No: T75692

16beta,17-Dihydroxy-ent-kaurane-19-oic acid

Cat.No: TN1194

Target: HIV Protease

6-Acetonyldihydrochelerythrine

Cat.No: TN3152

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

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