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T22832
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H-8 hydrochloride
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PKA |
Tyrosine Kinase/Adaptors |
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H-8 hydrochloride 是一种具有可逆性和 ATP 竞争性的 PKA 抑制剂。可用研究代谢疾病。 |
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T36879L
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H-Leu-Leu-OMe . HBr
H-Leu-Leu-OMe . HBr (16689-14-8 Free base)
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Others |
Others |
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H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。 |
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T3193
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Pimelic diphenylamide 106
Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8
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HDAC |
Chromatin/Epigenetic;
DNA Damage/DNA Repair |
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Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂，对HDAC1、 2和3的IC50值分别150、760和370 nM。 |
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T2568L
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Felypressin acetate
2-(L-Phenylalanine)-8-L-lysinevasopressin,醋酸苯赖加压素,PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond),PLV 2,PLV-2
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Vasopressin Receptor |
GPCR/G Protein |
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Felypressin acetate (PLV-2) 是加压素 1 的激动剂，作用于所有精氨酸加压素受体 1AS。 Felypressin acetate 可用于牙科手术。 |
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T31004
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Compound 8H
Compound-8H,Compound 8-H,Compound 343
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Compound 8H is an inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines. |
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T19519
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Pimelic Diphenylamide 106 analog
RGFA-8 analog,TC-H 106 analog
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Others |
Others |
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Pimelic Diphenylamide 106 analog is an Pimelic Diphenylamide 106 analog . |
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T9537
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N'-Nitro-D-arginine
N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸
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Others |
Others |
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N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。 |
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T27524
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H8-A5
H8 A5
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H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells. |
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T67324
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(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide
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(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67324，CAS号为 900160-98-7。 |
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T9553
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8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid
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Others |
Others |
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8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car 是一种 H+/K+ ATPase 抑制剂，IC50=0.38μM。 |
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T13410
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ZLDI-8
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Apoptosis;
Phosphatase;
Gamma-secretase;
Immunology/Inflammation related |
Apoptosis;
Immunology/Inflammation;
Metabolism;
Neuroscience;
Proteases/Proteasome;
Stem Cells |
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ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。 |
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T79492
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h-NTPDase8-IN-1
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Phosphatase |
Metabolism |
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h-NTPDase8-IN-1 是一种特异性氨磺酰苯甲酰胺类 h-NTPDases8 抑制剂（IC 50 = 0.28 ± 0.07 μM）。h-NTPDase8-IN-1 可用于研究 h -NTPDase 表达异常带来的疾病。 |
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T65411
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H-Tyr(tBu)-OH
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H-Tyr(tBu)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65411，CAS号为 18822-59-8。 |
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T126118
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Ilicicolin H
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Ilicicolin H 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126118，CAS号为 12689-26-8。 |
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T66400
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H-Phe(4-Ac)-OH
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H-Phe(4-Ac)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66400，CAS号为 122555-04-8。 |
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T61377
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NTPDase-IN-1
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NTPDase-IN-1 (compound 5a) is a selective inhibitor of NTPDase enzymes. It shows inhibitory activity against h-NTPDase-1, h-NTPDase-2, and h-NTPDase-8 with IC50 values of 0.05 μM, 0.23 μM, and 0.54 μM, respectively. NTPDase-IN-1 exerts non-competitive inhibition on h-NTPDase-1 and h-NTPDase-2, with a K m value of 21 μM for h-NTPDase-1. This compound is useful for investigating various conditions like cancer, immunologic disorders, and bacterial infections [1]. |
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T21598
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G3335
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H- Trp- Glu- OH 是一种选择性的、可逆的和细胞通透性的PPARγ拮抗剂，其Kd 约为 8 μM。H- Trp- Glu- OH 可能被开发为糖尿病研究中的先导化合物。 |
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T62703
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NTPDase-IN-2
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NTPDase-IN-2 (化合物 5g) 是一种具有选择性的NTPDase 抑制剂，其对h-NTPDase-2/-8的IC50值分别为 0.04 和 2.27 µM。NTPDase-IN-2 可非竞争性地抑制h-NTPDase-1/-2，其对h-NTPDase-2的Km 值为 74 µM。NTPDase-IN-2 可用于癌症、免疫学疾病以及细菌感染的研究。 |
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T66723
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H-D-Tyr(tBu)-OH
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|
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H-D-Tyr(tBu)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66723，CAS号为 186698-58-8。 |
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T66171
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H-Asp-OBzl
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|
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H-Asp-OBzl 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66171，CAS号为 7362-93-8。 |
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T65446
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H-D-Cys(Trt)-OH
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|
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H-D-Cys(Trt)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65446，CAS号为 25840-82-8。 |
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T66526
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H-D-Gly(allyl)-OH
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H-D-Gly(allyl)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66526，CAS号为 54594-06-8。 |
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T60935
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H-Tyr-Phe-OH
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H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂，在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ，可调节中性粒细胞样细胞中 IL-8 的产生。 |
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T36628
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PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8
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PROTACs |
PROTAC |
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PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].
PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra... |
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T74258
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HL-8
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HL-8 是一种靶向PI3K 激酶的PROTAC 分子。HL-8 在10 μM 浓度下 8 h 内对PI3K 激酶具有显着且完全的降解作用。HL-8 具有研究癌症疾病的潜力。 |
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T36746
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Leoidin
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Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM... |
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T36431
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7,10-dihydroxy-8(E)-Octadecenoic Acid
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7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1
1.Sohn, H.-R., Bae, J.-... |
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T83826
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1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
1,2,3,6,7,8-HxCDD,PCDD 67
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1,2,3,6,7,8-六氯二苯并-p-二噁英是一种多氯代二苯并二噁英（PCDD）。它是芳香烃受体（AhR; EC50s分别为5.4和9.3 nM，在4和8小时的报告检测中）的激动剂。1,2,3,6,7,8-六氯二苯并-p-二噁英（0.5和2 µg/kg）降低了小鼠对羊红血球的抗体产生。在动物饲料和靠近市政废物焚烧炉的空气中均有发现。 |
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T35723
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GRK-IN-1
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4-Amino-5-(bromomethyl)-2-methylpyrimidine is a heterocyclic building block.1,2 It has been used in the synthesis of vitamin B1 analogs and thiaminephosphoric acid esters.
|1. Abblard, J., Cronenberger, L., and Pacheco, H. Synthesis of the analogs of vitamin B1. Chim. Ther. 8(1), 98-110 (1973).|2. Leichssenring, G., and Joachim, S. The synthesis of thiaminephosphoric acid esters. Chem. Ber. 95, 767-772 (1962). |
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T35829
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CC-90005
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|
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CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM). CC-90005 can inhibit T cell activation by IL-2 expression[1].
CC-90005 shows the exquisite selectivity of CC-90005, with IC50s for all other family members of >3 μM[1].CC-90005 is a moderate inhibitor of both CYP2C9 (IC50=8 μM) and CYP2C19 (IC50=5.9 μM) in human liver microsomes[1].CC-90005 inhibits IL-2 expression in LRS... |
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T38357
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1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
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1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2
1.Jitian, S., White, S.R., Yang, H.-H.W., et al.Conventional high-performance liquid chromatography versus derivative spectrophotometry for the determination of 1,3,6-pyrenetrisulfonic acid trisodium salt and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt in the color additive D&C G... |
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T14382
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AZD7687
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Others |
Others |
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AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. AZD7687 markedly reduced postprandial TAG excursion with a steep concent |
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T37880
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OPC-167832
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OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1].
OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ... |
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T35983
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Carotenoid Mixture
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Carotenoid mixture is a mixture of carotenoids that contains the antioxidative and anti-inflammatory carotenoid capsanthin and the antioxidative vitamin A precursor β-carotene , as well as additional carotenoids and carotenoid esters.1,2,3,4
1.Kim, J.S., Lee, W.M., Rhee, H.C., et al.Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communicationChem. Biol. Interact.254146-155(2016) 2.Na... |
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T36887
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8(E),10(E),12(Z)-Octadecatrienoic Acid
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8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland... |
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T36629
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Givinostat
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Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1... |
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T36881
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NHC-diphosphate triammonium
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NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].
In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono... |
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T11864
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Iptacopan
LNP023
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Others |
Others |
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Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 |
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T37194
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5α-Androst-16-en-3α-ol
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5α-Androst-16-en-3α-ol is a steroid pheromone that has been found in boar testes and human male axillary sweat and has diverse biological activities.1,2It enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50= 0.4 μM).25α-Androst-16-en-3α-ol (0.1-1 μM) increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2and α2β2γ2subunit-containing GABAAreceptors.In vivo, 5α-androst-16-en-3α-ol (5-10 mg/kg) decreases immobility time in the forced s... |
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T36722
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Deltorphin II (trifluoroacetate salt)
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Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid... |
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T37847
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Zonisamide-13C2,15N
Zonisamide-13C2,15N
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... |
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T36539
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Nocardamine
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Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4
1.Lo... |
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T36978
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AS-99 TFA
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AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
AS-99 TFA is tested against a panel of 20 histone methyltransferases, including NSD1, NSD2, NSD3, and SETD2. NO significant inhibition is observed at 50 μM of AS-99 TFA on any of the tested... |
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T37736
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N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
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Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... |
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T38145
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Eltoprazine
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Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... |
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T36660
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Olsalazine-13C6
Olsalazine-13C6
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Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ... |
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T38002
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LEO 39652
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LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1].
LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin... |
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T37741
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N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
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T35426
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β-Defensin-1 (human) (trifluoroacetate salt)
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β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no... |
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T35406
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α-MSH TFA
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α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo... |
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