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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11383 |
GDP366
|
Survivin | Apoptosis |
GDP366 有效且特异性地抑制 survivin 和 Op18 的表达。 GDP366 增加染色体不稳定性,并通过抑制端粒酶活性诱导细胞衰老。 | |||
T74041 |
GDP-L-fucose
|
Endogenous Metabolite | Metabolism |
GDP-L-fucose 是一种广泛存在与真菌和植物中的核苷酸糖,参与从头代谢途径和次要的补救代谢途径。 | |||
T11382 | GDP-α-D-mannose disodium | Others | Others |
GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of | |||
T7606 |
Guanosine 5'-diphosphate disodium salt
5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用,也可以调节白 IL-6/stat-3 途径。 | |||
T72120 |
Guanosine 5'-diphosphate sodium
GDP sodium |
||
Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸,可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂,可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究,如炎症性贫血 (AI)。 | |||
T74042 | GDP-L-fucose disodium | ||
GDP-L-fucose disodium 是一种关键的核苷酸糖,主要作为岩藻糖寡糖生物合成中提供岩藻糖基团的底物。其形成依赖于两种途径:一是主要的从头代谢途径,二是次要的补救代谢途径。 | |||
T8684 |
Sotorasib
AMG-510 |
Ras | GPCR/G Protein; MAPK |
Sotorasib (AMG-510) 是一种 KRAS G12C 共价抑制剂,具有口服活性和选择性。Sotorasib 与 KRAS G12C 非活性构象的 GDP 状态结合,抑制 KRAS 及其下游信号的传导。Sotorasib 对 KRAS G12C 突变肿瘤具有抑制活性。 | |||
T8369 |
Adagrasib
MRTX849 |
Ras | GPCR/G Protein; MAPK |
Adagrasib (MRTX849) 是一种 KRAS G12C 共价抑制剂,具有口服活性和选择性。Adagrasib 与 KRAS G12C 非活性构象的 GDP 状态结合,抑制 KRAS 及其下游信号的传导。Adagrasib 对 KRAS G12C 突变肿瘤具有抑制活性。 | |||
T31919 |
Gdpflrfamide
Gly-asp-pro-phe-leu-arg-phe-amide |
||
Gdpflrfamide is a neuropeptide that existed in the snail Lymnaea stagnalis. | |||
T9198 |
SCH54292
|
Ras | GPCR/G Protein; MAPK |
SCH54292 是一种 GDP 交换抑制剂。 | |||
T8930 |
CID44216842
KUC103479N-02 |
CDK; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。 | |||
T40192 |
dGTP
2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate |
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
dGTP(2'-Deoxyguanosine-5'-triphosphate)作为脱氧核糖核酸(DNA)合成的基本单元,属于鸟苷核苷酸,对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。 | |||
T69529 |
BI-0474
|
Ras | GPCR/G Protein; MAPK |
BI-0474 是一种高效的 KRASG12C 抑制剂,对 GDP-KRAS:SOS1 蛋白-蛋白相互作用具有抑制作用,IC50 值为 7.0 nM。BI-0474 对携带 G12C 突变的 NCI-H358 细胞具有显著的抗增殖活性,在非小细胞肺癌异种移植模型中显示出显著的抗肿瘤活性。BI-0474 可用于研究癌症。 | |||
T13983 |
0990CL
|
cAMP; Others | GPCR/G Protein; Others |
0990CL 是一种有效的异三聚体Gαi subunit 特异性抑制剂,可与纯化的Go±在gdp 结合状态下相互作用,能够阻断α2AR 介导的cAMP 调控。 在细胞模型中低浓度0990CL 能够部分恢复cAMP 水平,高浓度的0990CL (10 μM)下,开始对细胞活力产生负面影响。 | |||
T7414 |
ARS-853
|
Apoptosis; Raf; Ras | Apoptosis; GPCR/G Protein; MAPK |
ARS-853 是一种选择性共价KRAS G12C 抑制剂,IC50为 2.5 μM。它通过与 GDP 结合的癌蛋白结合并阻止激活来抑制突变 KRAS 驱动的信号传导。 | |||
T15485 |
HJC0197
|
cAMP; Ras | GPCR/G Protein; MAPK |
HJC0197 是Epac1(cAMP 1 直接激活的交换蛋白) 和Epac2 拮抗剂,其对Epac2 的IC50值为5.9 μM。它在等浓度 cAMP 存在下能够降低 Epac1 介导的 Rap1-GDP 交换活性。它能够选择性阻断 cAMP 诱导的 Epac 活化。 | |||
T38170 |
RMC-0331
RM-023 |
Raf | MAPK |
RMC-0331 (RM-023) 是一种可口服且具有高效性的 SOS1 抑制剂。RMC-0331 具有潜在的抗癌活性,通过破坏 RAS-SOS1 相互作用阻断 RAS 激活。 | |||
T75247 | Mannose 1-phosphate | ||
Mannose 1-phosphate,一种内源性代谢物,通过GDP-甘露糖焦磷酸化酶可合成GDP-Man。 | |||
T26394 |
6-Alkynyl-fucose
6-Alk-Fuc |
||
6-Alkynyl-fucose, a widely used fucosylation probe, acts by strongly inhibiting fucosylation and GDP-fucose synthetase FX and halting hepatoma invasion. | |||
T63201 |
SOS1 activator 1
|
||
SOS1 activator 1 是一种 SOS1 介导的核苷酸交换的激活剂(Kd: 44 nM)。SOS1 是一种鸟嘌呤核苷酸交换因子,能与 Ras 蛋白结合,催化 GDP 与 RAS 上的 GTP 交换,使原来与 Ras 结合的 GDP 交换成 GTP。 | |||
T64537 | Guanosine 5′-diphospho-β-L-fucose sodium salt | ||
GDP-β-L-fucose is a metabolite in plant and animal. It used for microbe agglutination assay and agglutination inhibition assay. GDP-β-L-fucose is formed by the oxidation-reduction and epimerization of GDP-R-D-mannose in most organisms. | |||
T64000 | MRTX-EX185 | ||
MRTX-EX185 是一种有效的负载 GDP 的 KRAS 和 KRAS (G12D) 抑制剂,对 KRAS (G12D) 的 IC50=90 nM。MRTX-EX185 也能够结合 GDP 负载的 HRAS。 | |||
T75420 | alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) | ||
alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) 存在于幽门螺杆菌中。alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) 催化岩藻糖从供体 GDP-β-l-岩藻糖转移到 GlcNAc。 | |||
T83817 |
Isoguanosine-5'-O-diphosphate sodium
isoGDP |
||
Isoguanosine-5'-O-diphosphate (isoGDP),是GDP的一个异构体,也是crotonoside的一种磷酸化形式。isoGDP能抑制线粒体ATPase(IC50 = 3 µM)。 | |||
T80148 |
GRP (14-27) (human, porcine, canine)
|
Bombesin Receptor | GPCR/G Protein |
GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用,但 GMP 对此无影响。 | |||
T63927 | KRAS G12C inhibitor 25 | ||
KRAS G12C inhibitor 25 是 KRAS G12C 抑制剂。KRAS G12C inhibitor 25 能够抑制 KRAS-G12C 突变体的 SOS1 辅助的 GDP/GTP 交换活性,其 IC50 值为 0.48 nM。 | |||
T82329 | GDI2-IN-1 | ||
GDI2-IN-1(compound (+)-37)是β版GDP解离抑制剂GDI2的抑制剂,具有2.87 μM的IC50和36 μM的KD。在过表达GDI2的胰腺异种移植模型中,该化合物展示了显著的体内抗肿瘤效果。 | |||
T37154 | 7-Methylguanosine 5'-diphosphate sodium | ||
7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1]. 7-Methylguanosine 5’-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1].T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5’-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2]. [1]. Sonenberg N, et al. Nonspecific effect o... | |||
T38411 |
KRA-533
|
||
KRA-533, a potent KRAS agonist, directly targets the GTP/GDP binding pocket within the KRAS protein, inhibiting GTP cleavage. This inhibition leads to the buildup of constitutively active GTP-bound KRAS, which subsequently activates both apoptotic and autophagic cell death pathways specifically in cancer cells. | |||
T36740 | Guanosine 5’-diphosphate (sodium salt hydrate) | ||
Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)... | |||
T79928 |
Phosphomannose isomerase
|
||
Phosphomannose isomerase 是 GDP-Man 生物合成途径中关键的首要酶,负责催化 Fru6P 与 Man6P 之间的互转。该酶对于细胞壁合成及蛋白质糖基化过程至关重要。同时,作为一种潜在的抗真菌靶点,Phosphomannose isomerase 可以有效抑制 A. flavus。 | |||
T37422 |
Ras Inhibitory Peptide
|
||
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7210 |
Guanosine 5'-diphosphate
GDP,鸟苷-5ˊ-二磷酸 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate (GDP) 是核苷二磷酸,是潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。 | |||
T65209 | GDP-D-mannose disodium | ||
GDP-D-mannose disodium 是一种天然产物,可用于生命科学领域的相关研究,其产品编号为 T65209。 |