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Search Results for " fkbp "

23

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18610	PROTAC FKBP Degrader-3	Others	Others
	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
T14298	Rimiducid	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
T13884	Shield-1	Others	Others
	Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体，通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性，允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。
T14299	AP20187 B/B Homodimerizer	Others	Others
	AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体，用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。
T1784	Everolimus 依维莫司,RAD001,SDZ-RAD	Apoptosis; Others; mTOR; Autophagy	Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling
	Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物，也是一种口服活性的mTOR1选择性抑制剂。它与FKBP-12结合可产生免疫抑制复合物，还抑制肿瘤细胞增殖并诱导细胞凋亡和自噬，有免疫抑制和抗癌活性。
T11451	GPI-1046 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	GPI-1046 是一种无抗生素作用的亲免素配体，部分通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白 1 来减少乙醇摄入。
T13694	FKBP12 PROTAC RC32 RC32	Others	Others
	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
T2567	Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物，与靶器官中的孕酮受体和雌激素受体高亲和力地结合，可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素，用作激素避孕药。
T71840	FKBP12-IN-Q2
	FKBP12-IN-Q2 is an inhibitor of FKBP12.
T11291	FKBP12 PROTAC dTAG-13 dTAG-13	Epigenetic Reader Domain	Chromatin/Epigenetic
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
T11292	FKBP12 PROTAC dTAG-7 dTAG-7	Epigenetic Reader Domain	Chromatin/Epigenetic
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
T79184	FKBP51F67V-selective antagonist Ligand2	FKBP	Apoptosis; Autophagy; Immunology/Inflammation
	FKBP51F67V-selective antagonist Ligand2（示例3-3）是针对杏仁核中由FKBP51 F67V过表达引起的焦虑表型的有效逆转剂。本物质特异性地结合到FKBP51 F67V，与野生型FKBP51及FKBP52无亲和力。
T18597	dFKBP-1	Others	Others
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T6033	Zotarolimus ABT-578,佐他莫司,咗他莫司,A 179578	mTOR	PI3K/Akt/mTOR signaling
	Zotarolimus (ABT-578) 是一种免疫抑制剂，是雷帕霉素的衍生物，具有抗增殖活性。它被专门开发作为局部输送支架用于预防冠状动脉再狭窄。
T2648	Pimecrolimus SDZ-ASM 981,ASM 981,吡美莫司	Others	Others
	Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体，能与胞质受体特异性的结合。
T24788	Shield-2
	Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T13549	AP1867-3-(aminoethoxy)	Others	Others
	AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T13914	SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1	Others	Others
	SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
T13888	SLF	Others	Others
	SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.
T73817	SLF TFA
	SLF TFA 是 FK506 结合蛋白 (FKBP) 的合成配体，对FKBP51的亲和力为 3.1 μM，对FKBP12的IC50为 2.6 μM，可用于合成PROTAC 分子。
T80928	TSPO ligand-3	AUTACs	PROTAC
	TSPO ligand-3为AUTAC2的配体，其中AUTAC2包含p-氟苄基鸟嘌呤(FBnG)及FKBP合成配体(SLF)两部分，能在HeLa细胞中显著沉默FKBP12蛋白。
T74026	AUTAC2
	AUTAC2 是一种 FKBP12靶向自噬介导降解体 (AUTAC)。AUTAC2 包含一个 FBnG 和 SLF 部分，其中 SLF 与 FKBP12 非共价结合。
T76622	Suc-Ala-Leu-Pro-Phe-pNA
	Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) 是一种 FK-506 结合蛋白 (FKBP) 的底物。

化合物

PROTAC FKBP Degrader-3

Cat.No: T18610

Target: Others

Cat.No: T14298

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T13884

Target: Others

Cat.No: T14299

Synonym: B/B Homodimerizer

Target: Others

Cat.No: T1784

Synonym: 依维莫司,RAD001,SDZ-RAD

Target: Apoptosis, Others, mTOR, Autophagy

Cat.No: T11451

Synonym: 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯

Target: Others, HIV Protease

FKBP12 PROTAC RC32

Cat.No: T13694

Synonym: RC32

Target: Others

Cat.No: T2567

Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite

Cat.No: T71840

FKBP12 PROTAC dTAG-13

Cat.No: T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain

FKBP12 PROTAC dTAG-7

Cat.No: T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain

FKBP51F67V-selective antagonist Ligand2

Cat.No: T79184

Target: FKBP

Cat.No: T18597

Target: Others

Cat.No: T6033

Synonym: ABT-578,佐他莫司,咗他莫司,A 179578

Target: mTOR

Cat.No: T2648

Synonym: SDZ-ASM 981,ASM 981,吡美莫司

Target: Others

Cat.No: T24788

AP1867-3-(aminoethoxy)

Cat.No: T13549

Target: Others

SLF-amido-C2-COOH

Cat.No: T13914

Synonym: PROTAC FKBP12-binding moiety 1

Target: Others

Cat.No: T13888

Target: Others

Cat.No: T73817

Cat.No: T80928

Target: AUTACs

Cat.No: T74026

Suc-Ala-Leu-Pro-Phe-pNA

Cat.No: T76622

Cat. No.	Product Name	Target	Signaling Pathways
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 可与 FKBP12 结合形成高亲和力复合物 (Ki: 0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。
T1537	Rapamycin Sirolimus,AY 22989,雷帕霉素,NSC-2260804	Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Rapamycin (AY 22989) 属于大环内酯类天然产物，是一种 mTOR 抑制剂，具有特异性（HEK293 细胞：IC50=0.1 nM）。Rapamycin 具有免疫抑制活性，并能诱导自噬。
T2481	Ascomycin FK520,Immunomycin,子囊霉素,FR-900520	Phosphatase; Others; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物，具有免疫抑制特性。它也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥，并具有用于各种皮肤病研究的潜力。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。

天然产物

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Cat.No: T1537

Synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Cat.No: T2481

Synonym: FK520,Immunomycin,子囊霉素,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

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