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Search Results for " epoxide "

88

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37149	Carbamazepine 10,11-epoxide	Others	Others
	Carbamazepine 10,11-epoxide 是抗惊厥药卡马西平 (carbamazepine) 的活性代谢物。它由卡马西平通过微粒体中的细胞色素 P450 (CYP) 同种型 CYP3A4 和 CYP2C8 形成，微粒体分别由表达 CYP3A4 或 CYP2C8 的 HepG2 细胞制备。它对小鼠电击诱发的癫痫发作具有抗惊厥活性。
TQ0300	Conduritol B epoxide	Glucosidase	Metabolism
	Conduritol B epoxide 是不可逆的，β-glucosidase 共价抑制剂。
T19277	Dexamethasone 9,11-epoxide	Others	Others
	Dexamethasone 9,11-epoxide 是一种萃取得到的化合物，是制备地塞米松的中间体。
T35973	Cholesterol-5α,6α-epoxide Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) 是胆固醇氧化产生的代谢产物。在应用他莫昔芬和 PBPE 后，5α,6α-环氧胆甾烷醇通过与 LXRβ 结合诱导三酰甘油生物合成。
T36730	Vitamin K1 2,3-epoxide Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide	Others	Others
	Vitamin K1 2,3-epoxide (Phylloquinone oxide) 可被还原为维生素 k,参与维生素k的循环。
T83857	Soluble Epoxide Hydrolase PROTAC 1a sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a
	Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术，通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解，特异性抑制sEH的水解酶活性(IC50 = 0.8 nM)，相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解，并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接，表明能减少ER应激。
T12974	Soluble epoxide hydrolase inhibitor	Others	Others
	Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4).
T29690	Aflatoxin G1 9,10-epoxide
	Aflatoxin G1 9,10-epoxide is a biochemical.
T32059	Hepaxanthin Vitamin A epoxide
	Hepaxanthin is a carotenoid.
T7898	AUDA	Epoxide Hydrolase	Metabolism
	AUDA 是可溶性环氧化物水解酶 (sEH) 抑制剂，在小鼠和人 sEH 的IC50分别为 18 和 69 nM，具有抗炎特性。
T34627	SFO Safrole epoxide,Safrole oxide
	SFO is an endothelial-to-mesenchymal transition (EndoMT) inducer.
T7199	TPPU	Epoxide Hydrolase	Metabolism
	TPPU 是一种可溶性环氧化物水解酶(sEH)抑制剂，对猴子和人类的IC50分别为37和3.7 nM。
T14557	BI-1935	Epoxide Hydrolase	Metabolism
	BI-1935 是可溶性环氧化物水解酶抑制剂，用于与心血管疾病相关的疾病的研究。
T17158	trans-AUCB t-AUCB	Epoxide Hydrolase	Metabolism
	trans-AUCB (t-AUCB) 是口服具有活力的、选择性的可溶性环氧水解酶 (sEH) 抑制剂，对人，小鼠和大鼠的 sEH 的IC50分别为 1.3 nM，8 nM，8 nM。它具有抗神经胶质瘤特性。
T34070	Piperitenone oxide Rotundifolone,Lippione,cis-Piperitenone epoxide,Piperitenone oxide, (+-)-
	Piperitenone oxide is a major chemical constituent of the carvone pathway MS essential oil.
T14315	AR-9281 APAU	Epoxide Hydrolase	Metabolism
	AR-9281 (APAU) 是选择性的可溶性环氧化物水解酶抑制剂，可用于研究高血压和 2 型糖尿病。
T10900	CUDA	PPAR; Epoxide Hydrolase	DNA Damage/DNA Repair; Metabolism
	CUDA 是一种可溶性环氧水解酶抑制剂，对小鼠 sEH 和人 sEH 作用的 IC50分别为 11.1 和 112 nM。它能选择性地上调过氧化物酶体增殖激活受体 PPARα的活性，有用于心血管疾病的研究潜力。
T11147	EC5026 BPN-19186	Epoxide Hydrolase	Metabolism
	EC5026 (BPN-19186) 是首创的，非阿片类的，可溶性环氧水解酶 (sEH) 抑制剂，它可有效缓解发炎性和神经性疼痛。
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T17196	UC-1728 t-TUCB	Epoxide Hydrolase	Metabolism
	UC-1728 (t-TUCB) 是一种兔子可溶性环氧化物水解酶抑制剂，兔子肝脏中测得其IC50=2 nM。
T130051	Detigloylswietenine, 2-Hydroxy, 8?,30?-epoxide, 3-
	Detigloylswietenine, 2-Hydroxy, 8?,30?-epoxide, 3- 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130051。
T21859	ARM1	Aminopeptidase; Epoxide Hydrolase	Metabolism
	ARM1 是氨基肽酶和环氧化物水解酶抑制剂，IC50分别为为7.61 µM 和12.4 µM。
T15430	GSK2256294A GSK 2256294	Others; Epoxide Hydrolase	Metabolism; Others
	GSK2256294A (GSK 2256294) 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂，IC50 分别为 27 pM、61 pM 和 189 pM。
T0355	Valpromide Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide	Epoxide Hydrolase; HSV	Metabolism; Microbiology/Virology
	Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。
T8315	1-Cyclohexyl-3-dodecyl urea CDU,N-Cyclohexyl-N-dodecyl urea,NCND	Epoxide Hydrolase	Metabolism
	1-Cyclohexyl-3-dodecyl urea (NCND) 是高选择性的可溶性环氧化物水解酶 (sEH) 抑制剂，能够增强血管紧张素 II (Ang II) 高血压中的环氧二十碳三烯酸 (EETs) 水平，并降低血压。
T23044	N,N'-Dicyclohexylurea DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲	Epoxide Hydrolase	Metabolism
	N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。
T131605	Crotepoxide (Futoxide)
	Crotepoxide (Futoxide) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131605。
T2716	1,3-Diphenylurea	Epoxide Hydrolase	Metabolism
	1,3-Diphenylurea 与环氧化物水解酶活性有关。
T63536	Dual FAAH/sEH-IN-1	FAAH; Epoxide Hydrolase	Metabolism; Neuroscience
	Dual FAAH/sEH-IN-1 是具有高度亲和力的sEH(可溶性环氧水解酶) (IC50: 9.6 nM) 和FAAH(脂肪酸酰胺水解酶) (IC50: 7 nM) 双重抑制剂，具有抗炎活性。
T17025	Tecarfarin ATI-5000,ATI-5923	Others	Others
	Tecarfarin (ATI-5923) 是一种具有口服活性和有效性的维生素 K 环氧化物还原酶 (VKOR) 拮抗剂和大麻素-1受体反向激动剂，具有抗血栓形成活性，可减轻小鼠的腹痛并增加肠道转运。
T38367	CAY10640 sEH inhibitor-1	Epoxide Hydrolase	Metabolism
	CAY10640 (sEH inhibitor-1)一种有效的、具有口服活性、可溶于水的环氧化物水解酶 (sEH) 抑制剂，对人和鼠中的sEH 具有抑制作用，IC50s 分别为 0.4 和 5.3 nM。
T60358	sEH inhibitor-7	Epoxide Hydrolase	Metabolism
	sEH inhibitor-7是一种可溶性环氧化物水解酶（sEH）抑制剂，对人和小鼠的 sEH 有抑制作用，IC 50 s 分别为 6.2 μM 和0.15 μM 。sEH inhibitor-7与抗炎活性分子有关。
T9832	(Rac)-EC5026 Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-	Epoxide Hydrolase	Metabolism
	(Rac)-EC5026 ((Rac)-BPN-19186) 是一种有效的可溶性环氧水解酶 (sEH) 哌啶抑制剂，Ki 值为 0.06 nM。(Rac)-EC5026 可用于帕金森氏病和路易体痴呆 (DLB) 的研究。
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase...
T68786	Orniplabin
	Orniplabin, also known as SMTP-7 is a dual inhibitor of thrombolysis and soluble epoxide hydrolase. SMTP-7 promotes thrombolysis and inhibits soluble epoxide hydrolase.
T24778	sEH-IN-12 sEH inhibitor 12,sEH-inhibitor-12
	sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH).
T32310	Johnstonol
	Johnstonol is an specifically halogenated epoxide obtained from the red alga.
T37239	(±)19(20)-EpDTE
	(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase.
T32385	Keto-anhydrokinamycin
	Keto-anhydrokinamycin, as a keto-epoxide kinamycin intermediate, is isolated from Streptomyces murayamaensis.
T37334	(±)11,12-DiHETE
	(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.
T68259	TUPS
	TUPS is a selective soluble epoxide hydrolase inhibitor which protects against isoprenaline-induced cardiac hypertrophy.
T17024	Tecarfarin sodium ATI-5923 sodium	Others	Others
	Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity.
T37226	(±)7(8)-EpDTE
	(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase.
T13042	SWE101	Others	Others
	SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively).
T70626	MS 347a
	MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).
T35496	(±)13(14)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy m...
T61541	sEH inhibitor-6
	sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1].
T64291	sEH inhibitor-1
	sEH inhibitor-1 (compound TCPU ) 是一种有效的、口服具有活力的可溶性环氧化物水解酶 (sEH) 抑制剂，对人和鼠 she 的 IC50 值分别为 0.4 和 5.3 nM。
T35493	(±)10(11)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in infla...
T37652	5(S),6(R)-DiHETE
	5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.

化合物

Carbamazepine 10,11-epoxide

Cat.No: T37149

Target: Others

Conduritol B epoxide

Cat.No: TQ0300

Target: Glucosidase

Dexamethasone 9,11-epoxide

Cat.No: T19277

Target: Others

Cholesterol-5α,6α-epoxide

Cat.No: T35973

Synonym: Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176

Target: Others

Vitamin K1 2,3-epoxide

Cat.No: T36730

Synonym: Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide

Target: Others

Soluble Epoxide Hydrolase PROTAC 1a

Cat.No: T83857

Synonym: sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a

Soluble epoxide hydrolase inhibitor

Cat.No: T12974

Target: Others

Aflatoxin G1 9,10-epoxide

Cat.No: T29690

Cat.No: T32059

Synonym: Vitamin A epoxide

Cat.No: T7898

Target: Epoxide Hydrolase

Cat.No: T34627

Synonym: Safrole epoxide,Safrole oxide

Cat.No: T7199

Target: Epoxide Hydrolase

Cat.No: T14557

Target: Epoxide Hydrolase

Cat.No: T17158

Synonym: t-AUCB

Target: Epoxide Hydrolase

Piperitenone oxide

Cat.No: T34070

Synonym: Rotundifolone,Lippione,cis-Piperitenone epoxide,Piperitenone oxide, (+-)-

Cat.No: T14315

Synonym: APAU

Target: Epoxide Hydrolase

Cat.No: T10900

Target: PPAR, Epoxide Hydrolase

Cat.No: T11147

Synonym: BPN-19186

Target: Epoxide Hydrolase

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Cat.No: T17196

Synonym: t-TUCB

Target: Epoxide Hydrolase

Detigloylswietenine, 2-Hydroxy, 8?,30?-epoxide, 3-

Cat.No: T130051

Cat.No: T21859

Target: Aminopeptidase, Epoxide Hydrolase

Cat.No: T15430

Synonym: GSK 2256294

Target: Others, Epoxide Hydrolase

Cat.No: T0355

Synonym: Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide

Target: Epoxide Hydrolase, HSV

1-Cyclohexyl-3-dodecyl urea

Cat.No: T8315

Synonym: CDU,N-Cyclohexyl-N-dodecyl urea,NCND

Target: Epoxide Hydrolase

N,N'-Dicyclohexylurea

Cat.No: T23044

Synonym: DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲

Target: Epoxide Hydrolase

Crotepoxide (Futoxide)

Cat.No: T131605

1,3-Diphenylurea

Cat.No: T2716

Target: Epoxide Hydrolase

Dual FAAH/sEH-IN-1

Cat.No: T63536

Target: FAAH, Epoxide Hydrolase

Cat.No: T17025

Synonym: ATI-5000,ATI-5923

Target: Others

Cat.No: T38367

Synonym: sEH inhibitor-1

Target: Epoxide Hydrolase

sEH inhibitor-7

Cat.No: T60358

Target: Epoxide Hydrolase

Cat.No: T9832

Synonym: Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-

Target: Epoxide Hydrolase

Cat.No: T36696

Cat.No: T68786

Cat.No: T24778

Synonym: sEH inhibitor 12,sEH-inhibitor-12

Cat.No: T32310

(±)19(20)-EpDTE

Cat.No: T37239

Keto-anhydrokinamycin

Cat.No: T32385

(±)11,12-DiHETE

Cat.No: T37334

Cat.No: T68259

Tecarfarin sodium

Cat.No: T17024

Synonym: ATI-5923 sodium

Target: Others

Cat.No: T37226

Cat.No: T13042

Target: Others

Cat.No: T70626

(±)13(14)-EpDPA

Cat.No: T35496

sEH inhibitor-6

Cat.No: T61541

sEH inhibitor-1

Cat.No: T64291

(±)10(11)-EpDPA

Cat.No: T35493

5(S),6(R)-DiHETE

Cat.No: T37652

Cat. No.	Product Name	Target	Signaling Pathways
TN4130	Germacrone 4,5-epoxide	gp120/CD4; IL Receptor; P450	Immunology/Inflammation; Metabolism
	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
TN4229	Humulene epoxide II	Antifection	Microbiology/Virology
	Humulene epoxide II has antimalarial activity.
TN4958	Schisandrin C epoxide	Others	Others
	Schisandrin C epoxide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4958，CAS号为 81345-36-0。
TN6794	N-(3-methoxybenzyl)-octadecanamide	Others	Others
	N-(3-methoxybenzyl)-octadecanamide 从玛卡 (Lepidium meyenii Walp.) 转化而来。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
TN5329	Epitulipinolide diepoxide
	Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells.
T73797	Cladospirone bisepoxide
	Cladospirone bisepoxide 是一种从真菌培养物中分离出来的代谢物。Cladospirone bisepoxide 对几种细菌和真菌表现出选择性抗生素活性，并在低浓度下抑制Lepidium sativum 萌发。
T15039	Cytochalasin E	Others	Others
	Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Germacrone 4,5-epoxide

Cat.No: TN4130

Target: gp120/CD4, IL Receptor, P450

Humulene epoxide II

Cat.No: TN4229

Target: Antifection

Schisandrin C epoxide

Cat.No: TN4958

Target: Others

N-(3-methoxybenzyl)-octadecanamide

Cat.No: TN6794

Target: Others

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

Epitulipinolide diepoxide

Cat.No: TN5329

Cladospirone bisepoxide

Cat.No: T73797

Cat.No: T15039

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

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