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29

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11281L	FGI-106 tetrahydrochloride	Virus Protease; HCV Protease; Influenza Virus; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	FGI-106 tetrahydrochloride 对多种病毒具有抑制活性，有抗埃博拉病毒，裂谷病毒和登革热病毒的 EC50分别为 100 nM，800 nM 和 400-900 nM，抑制非失血性发热病毒HCV 和HIV-1的EC50分别为 200 nM 和 150 nM 。
TP2184	matrix protein (3-15) [Zaire ebolavirus]	Others	Others
	matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of
T8502	N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide	Influenza Virus	Microbiology/Virology
	N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide 通过与表面糖蛋白结合抑制埃博拉病毒进入宿主细胞，该化合物抑制埃博拉病毒，EC50 为 3.9 μM。
T8686	VUN65671	Others	Others
	Compound 35 是埃博拉 (Mayinga) 和马尔堡 (安哥拉) 传染性病毒的优良抑制剂。
T80640	EBOV-IN-1	Influenza Virus	Microbiology/Virology
	EBOV-IN-1 是一种针对埃博拉病毒(EBOV)的金刚烷二肽哌嗪抑制剂。它通过与Niemann-Pick C1 (NPC1)相互作用，阻断该蛋白与启动病毒穿透宿主细胞的EBOV糖蛋白(GP)的结合，进而抑制EBOV的感染。EBOV-IN-1对假型EBOV感染具有IC50为13 nM的抑制效力。
T17190	U18666A	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	U18666A 是一种细胞渗透性药物，是一种胆固醇合成和转运抑制剂，抑制埃博拉病毒，登革热病毒和人类丙型肝炎病毒的复制。
T7766	Remdesivir 瑞德西韦,GS-5734	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Remdesivir (GS-5734) 是一种核苷类似物，一种广谱的抗病毒化合物，通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性，对 COVID-19 有潜在治疗价值。
T16697	Pyronaridine tetraphosphate	Topoisomerase	DNA Damage/DNA Repair
	Pyronaridine tetraphosphate 是一种具有口服活性的、含甘露醇的DNA 拓扑异构酶 2 的抑制剂和红细胞裂殖杀灭剂，具有抗疟活性和抗肿瘤活性。Pyronaridine tetraphosphate 可治疗 P. falciparum 和 Echinococcus granulosus感染，可减轻埃博拉病毒传播。
T8501	3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide	Influenza Virus	Microbiology/Virology
	3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide 具有抗埃博拉病毒的抗病毒活性靶向表面暴露的糖蛋白并抑制病毒进入宿主细胞。 Vero 细胞的体外研究表明，该化合物抑制病毒复制，EC50 为 0.38 μM。
T77105	Odesivimab
	Odesivimab 是一种人源化单克隆抗体，靶向埃博拉病毒糖蛋白，重组组氨酸标记的马科纳毒株埃博拉病毒糖蛋白胞外域蛋白的 KD 值为 7.74 nM。Odesivimab 可用于埃博拉病毒感染的研究。
T77119	Porgaviximab
	Porgaviximab 是一种单克隆抗体，可用于埃博拉病毒感染研究。
T68749	EBOV-IN-C31
	EBOV-IN-C31 is a novel PP1-targeting Ebola Virus (EBOV) inhibitor with improved pharmacological properties.
T77051	Larcaviximab
	Larcaviximab (c4G7-N) 是一种IgG1kappa 抗Ebola virus 糖蛋白嵌合单克隆抗体。
T62709	EBOV-GP-IN-1
	EBOV-GP-IN-1 (Compound 28) 是一种有效的 Ebola 进入抑制剂，能够作用于埃博拉病毒包膜糖蛋白（EBOV-GP）(IC50: 0.05 μM)。
T39335	Anti-virus agent 1 Anti-virus agent 1,Remdesivir isopropyl ester analog
	Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).
T82996	Antiviral agent 27
	Antiviralagent 27 (Compound 12) 表现出针对 Ebola 病毒的活性，其半抑制浓度（EC50）为 14 nM。
T60623	As-358
	As-358 对埃博拉病毒 (IC50 = 47.5 μM) 和马尔堡病毒 (IC50 = 3.7 μM) 具有抑制作用。
T77150	Cosfroviximab
	Cosfroviximab(c13C6-FR1)是一种抗埃博拉病毒糖蛋白(EBOV-GP)的鼠/人嵌合单克隆抗体。
T30443	BIBX 1382 Dihydrochloride Falnidamol dihydrochloride,BIBX1382 Dihydrochloride,BIBX-1382 Dihydrochloride,BIBX 1382 2HCl,Falnidamol 2HCl
	BIBX 1382 Dihydrochloride prevents Lassa and Ebola virus glycoprotein-dependent cells from entering the body. It can be used as a tool to understand conserved virus-host interactions and suggests that host cell kinases may be targets for broad-spectrum th
T71618	Oxocarbazate
	Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible...
T15554	IHVR-19029	Others	Others
	IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift
T41177	Galidesivir dihydrochloride BCX 4430
	Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.
T11281	FGI-106	Others	Others
	FGI-106 is a potent, broad-spectrum inhibitor demonstrating activity against various viruses, including Ebola, Rift Valley Fever, and Dengue Fever, exhibiting EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. Furthermore, it effectively inhibits non-hemorrhagic fever viruses such as HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively.
T70941	CLR01 sodium
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
T11352	Galidesivir triphosphate BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870	Others	Others
	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.
T60959	As-358 hydrochloride
	As-358 (hydrochloride) 显示出良好的体内安全性，并且抑制埃博拉病毒和马尔堡病毒，IC50值分别为 9.1 μM 和 18.1 μM。
T71275	CID16725315
	Thiocarbazate, also known as CID16725315, is an inhibitor of human cathepsin L. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection. With respect to the development of antiviral agents, inhibitors of human cathepsin L are not subject to resistance because of rapid mutations of the viral genome. Cathepsin L is therefore an attractive target for drug development.
T69731	Remdesivir maleate
	Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Remdesivir is a broad spectrum anti-viral drug that has shown to inhibit SARS-CoV-2, in vitro and in vivo. Efficacy of remdesivir against Ebola virus has been demonstrated. Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary les...
T73652	Eritoran
	Eritoran是一种Toll样受体4 (TLR4) 拮抗剂，能够保护小鼠免受包括埃博拉病毒(EBOV)、马尔堡病毒(MARV)在内的致命流感病毒感染。该化合物通过降低粒细胞增多水平，可能有助于减轻“细胞因子风暴”的严重程度，抑制丝状病毒感染的发病机制。

化合物

FGI-106 tetrahydrochloride

Cat.No: T11281L

Target: Virus Protease, HCV Protease, Influenza Virus, HIV Protease

matrix protein (3-15) [Zaire ebolavirus]

Cat.No: TP2184

Target: Others

N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide

Cat.No: T8502

Target: Influenza Virus

Cat.No: T8686

Target: Others

Cat.No: T80640

Target: Influenza Virus

Cat.No: T17190

Target: Others, HCV Protease

Cat.No: T7766

Synonym: 瑞德西韦,GS-5734

Target: SARS-CoV, DNA/RNA Synthesis

Pyronaridine tetraphosphate

Cat.No: T16697

Target: Topoisomerase

3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide

Cat.No: T8501

Target: Influenza Virus

Cat.No: T77105

Cat.No: T77119

Cat.No: T68749

Cat.No: T77051

Cat.No: T62709

Anti-virus agent 1

Cat.No: T39335

Synonym: Anti-virus agent 1,Remdesivir isopropyl ester analog

Antiviral agent 27

Cat.No: T82996

Cat.No: T60623

Cat.No: T77150

BIBX 1382 Dihydrochloride

Cat.No: T30443

Synonym: Falnidamol dihydrochloride,BIBX1382 Dihydrochloride,BIBX-1382 Dihydrochloride,BIBX 1382 2HCl,Falnidamol 2HCl

Cat.No: T71618

Cat.No: T15554

Target: Others

Galidesivir dihydrochloride

Cat.No: T41177

Synonym: BCX 4430

Cat.No: T11281

Target: Others

Cat.No: T70941

Galidesivir triphosphate

Cat.No: T11352

Synonym: BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870

Target: Others

As-358 hydrochloride

Cat.No: T60959

Cat.No: T71275

Remdesivir maleate

Cat.No: T69731

Cat.No: T73652

Cat. No.	Product Name	Target	Signaling Pathways
TN1480	Cephaeline 吐根鹼,吐根酚碱	Virus Protease; Influenza Virus; HIF	Angiogenesis; Chromatin/Epigenetic; Microbiology/Virology
	Cephaeline 对受保护的原代 CLL 细胞具有高度活性（相对 IC50 为 35nM），并通过抑制 HIF-1α± 和扰乱细胞内氧化还原稳态发挥作用。
T3S1852	Cephaeline hydrochloride	Others; Virus Protease; Influenza Virus	Microbiology/Virology; Others
	Cephaeline hydrochloride 是 Indian Ipecac 中的一种酚类生物碱。它有效抑制病毒 ZIKV 和 EBOV 感染。

天然产物

Cat.No: TN1480

Synonym: 吐根鹼,吐根酚碱

Target: Virus Protease, Influenza Virus, HIF

Cephaeline hydrochloride

Cat.No: T3S1852

Target: Others, Virus Protease, Influenza Virus

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