16
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4517 |
L189
|
DNA; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L189 是一种人类 DNA 连接酶抑制剂,抑制 hLigI/III/IV,IC50值分别为5、9 和 5 μM。 | |||
T3103 |
L67
DNA Ligase Inhibitor |
DNA; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂,抑制 DNA 连接酶 I 和 III,IC50为10μM。 | |||
T1724 |
SCR7 pyrazine
SCR7,SCR7 吡嗪 |
Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SCR7 pyrazine (SCR7) 是一种 DNA 连接酶 IV 抑制剂,以连接酶 IV 依赖的方式阻断非同源末端连接。它也是 CRISPR/Cas9的增强子,可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡,具有抗癌活性。 | |||
T9150 |
SCR130
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- |
Apoptosis; Others; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂,可诱导细胞凋亡并,具有抗癌活性。 它特异性依赖连接酶 IV,抑制 DNA 的末端连接。 | |||
T6611 |
NSC697923
2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
E1/E2/E3 Enzyme | Ubiquitination |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ... | |||
T3340 |
SCR7
|
Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SCR7 是一种特异性 DNA 连接酶 IV 抑制剂,可阻断非同源末端连接。它是一种不稳定的形式,可以自动循环成稳定形式的 SCR7 pyrazine。它也是CRISPR/Cas9的增强子,可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡并具有抗癌活性。 | |||
T60753 |
L82
|
DNA | DNA Damage/DNA Repair |
L82 是一种 DNA 连接酶 1 (DNA Lig1) 抑制剂 (hLig1 IC50=12 μM),具有选择性和非竞争性。L82 对乳腺癌细胞表达出抗增殖活性。 | |||
T25817 |
Mitonafide
NSC-300288,米托萘胺,NSC300288,NSC 300288 |
Antibacterial | Microbiology/Virology |
Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。 它是一种 DNA 嵌入剂。 | |||
T6610 |
XI-006
NSC 207895,可可碱 |
Mdm2; p53 | Apoptosis |
XI-006 (XI-006) 是一种DNA 破坏剂、抗肿瘤剂和p53的激活剂。 | |||
T36733 |
HLI373 dihydrochloride
|
||
HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 dihydrochloride exhibits antimalarial activity[2]. | |||
T79924 |
T4 RNA ligase
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
T4 RNA ligase为一RNA连接酶,催化单链DNA分子的连接作用。该酶在酶促低核糖核苷酸合成及RNA 3'端标记过程中应用。 | |||
T78166 |
MEL24
|
Others | Others |
MEL24为Mdm2 E3连接酶抑制剂,通过p53依赖机制降低细胞存活率,增强对DNA损伤剂的敏感性,适用于体外抗肿瘤研究。 | |||
T75343 |
JOE
|
||
JOE,作为一种荧光染料,主要应用于 DNA 测序、PCR 以及 LCR 扩增。其吸光度和发射波长分别为 525 nm 和 550 nm。 | |||
T22087 |
HLI 373
|
||
HLI373 是一种有效的 Hdm2抑制剂, Hdm2 是一种泛素连接酶(E3)。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis),并且具有抗疟疾 (antimalarial) 活性。 | |||
T69117 | Pinafide | ||
Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental tumors and shown to be inhibitor of two DNA viruses. Pinafide blocks cell growth by inhibiting DNA and RNA synthesis. It has been shown to bind to double-helical DNA by intercalation. Pinafide inhibited the activity of M. tuberculosis NAD⁺-dependent DNA ligase A at concentrations ... | |||
T74410 | PROTAC AR-V7 degrader-1 | ||
PROTACAR-V7 degrader-1 (Compound 6)为一种口服有效的,选择性针对AR-V7的降解剂,DC50值为0.32 µM,其作用机制主要是通过VHL E3连接酶将其招募至雄激素受体DNA结合域(AR DBD)。此外,PROTACAR-V7 degrader-1在表达AR-V7的22Rv1细胞系中展现出了活性,EC50值为0.88 µM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6407 |
β-Lapachone
3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501 |
IDO; Apoptosis; Topoisomerase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism |
β-Lapachone (ARQ-501) 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。 |