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15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8694	ML406	Antibacterial; Antibiotic	Microbiology/Virology
	ML406 是一种小分子探针，通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性，IC50为 30 nM。
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate	SGLT	GPCR/G Protein
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进尿液中葡萄糖的排泄，可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。
T2389	Dapagliflozin 达格列净,BMS-512148	SGLT; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein
	Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可促进尿液中葡萄糖的排泄，在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
T15052	Dapansutrile	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性，可用于研究缓解疼痛。
T9430	Venadaparib NOV140101,IDX-1197	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂，对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复，可研究实体瘤。
T67849	O-Desethyl Dapagliflozin Empagliflozin-4	SGLT	GPCR/G Protein
	O-Desethyl Dapagliflozin (Empagliflozin-4) 是一种 SGLT2 抑制剂, IC50=33nM.
T4076	Fondaparinux sodium Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra	Factor Xa	Metabolism
	Fondaparinux sodium (SR-90107A) 是抗凝血酶依赖性的 factor Xa 抑制剂。
T1093	Adapalene CD271,阿达帕林	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Adapalene (CD271) 是一种合成类视黄醇，局部应用于痤疮。它以非竞争性方式抑制 GOT1的酶活性，具有抗肿瘤活性。它是一种 RAR 激动剂，对 RARβ、RARγ、RARα的AC50值分别为 2.3 nM、9.3 nM 和 22 nM。
T10957	Dapagliflozin impurity	Others	Others
	Dapagliflozin impurity is the enantiomer of Dapagliflozin, Dapagliflozin is a sodium glucose transporter 2 inhibitor.
T35619	Dapagliflozin-3-O-β-D-Glucuronide
	Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]
T31203	Dapaconazole
	Dapaconazole is used as a drug candidate for antifungals.
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
T10246	Adapalene sodium salt CD 271 sodium salt,阿达帕林钠	Others	Others
	Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.
T10958	Dapagliflozin-d5 BMS-512148 D5	Others	Others
	Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor.
T39147	Venadaparib hydrochloride IDX-1197 hydrochloride
	Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research.

化合物

Cat.No: T8694

Target: Antibacterial, Antibiotic

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat.No: T4460

Synonym: BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate

Target: SGLT

Dapagliflozin

Cat.No: T2389

Synonym: 达格列净,BMS-512148

Target: SGLT, HIF

Cat.No: T15052

Target: NOD-like Receptor (NLR), NOD

Cat.No: T9430

Synonym: NOV140101,IDX-1197

Target: PARP

O-Desethyl Dapagliflozin

Cat.No: T67849

Synonym: Empagliflozin-4

Target: SGLT

Fondaparinux sodium

Cat.No: T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra

Target: Factor Xa

Cat.No: T1093

Synonym: CD271,阿达帕林

Target: Apoptosis, Retinoid Receptor, Autophagy

Dapagliflozin impurity

Cat.No: T10957

Target: Others

Dapagliflozin-3-O-β-D-Glucuronide

Cat.No: T35619

Cat.No: T31203

Fondaparinux free base

Cat.No: T71532

Adapalene sodium salt

Cat.No: T10246

Synonym: CD 271 sodium salt,阿达帕林钠

Target: Others

Dapagliflozin-d5

Cat.No: T10958

Synonym: BMS-512148 D5

Target: Others

Venadaparib hydrochloride

Cat.No: T39147

Synonym: IDX-1197 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T4889	2,6-Diaminoheptanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。

天然产物

2,6-Diaminoheptanedioic acid

Cat.No: T4889

Target: Others, Endogenous Metabolite

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