25
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5318 |
666-15
CREB inhibitor |
Epigenetic Reader Domain | Chromatin/Epigenetic |
666-15 (CREB inhibitor) 是一种选择性CREB 抑制剂,IC50为 81 nM,可抑制乳腺癌异种移植模型中的肿瘤生长。 | |||
T8890 |
653-47 hydrochloride
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
653-47 hydrochloride 是一种增强剂,能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。它也是 CREB 抑制剂,IC50为 26.3 μM。 | |||
T7856 |
Naphthol AS-E
色酚 AS-E,nAS-E |
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
Naphthol AS-E (nAS-E) 是一种具有细胞渗透性的KIX-KID 相互作用的抑制剂,可用于癌症研究。它直接结合 CBP 的 KIX 域,Kd 为 8.6 µM,阻断 KIX 域和 KID 域的相互作用,IC50为 2.26 µM。 | |||
T3973 |
PF-CBP1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PF-CBP1 是一种高选择性的 CREB 结合蛋白 (CREBBP) 溴结构域抑制剂。它抑制 CREBBP (IC50: 125 nM) 和 p300 溴结构域 (IC50: 363 nM)。 | |||
T24212 |
XX-650-23
XX65023,XX 650 23 |
Apoptosis; Epigenetic Reader Domain | Apoptosis; Chromatin/Epigenetic |
XX-650-23 是一种小分子 CREB 抑制剂,阻断 CREB 与其所需的共激活因子 CBP(CREB 结合蛋白)之间的关键相互作用,诱导AML细胞凋亡和细胞周期停滞,可用于研究急性髓系白血病 (AML)。 | |||
T15216 |
EML 425
|
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
EML425 是一种有效的选择性 CREB 结合蛋白 (CBP)/p300 抑制剂,IC50为 2.9 和 1.1 μM。 | |||
T8774 |
MS7972
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
MS7972 是一种小分子,能阻断人 p53 和 CREB 结合。它在50 μM 的时候几乎可以完全阻断 BRD 的相互作用。 | |||
T7297 |
KG-501
Naphthol AS-E phosphate,色酚AS-E磷酸盐 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
KG-501 (Naphthol AS-E phosphate) 是一种 cAMP 反应元件结合蛋白抑制剂,IC50为6.89 μM。 | |||
T3217 |
PF-CBP1 hydrochloride
PF-CBP1 HCl |
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂,抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达,也可下调皮质神经元 RGS4 的表达,可用于癫痫和帕金森病等神经疾病的研究。 | |||
T27083 |
Crebinostat
|
Epigenetic Reader Domain; Histone Acetyltransferase; HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂,对 HDAC1、HDAC2、HDAC3 和 HDAC6 有抑制作用, IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可增加在体外神经元的突触蛋白 1 斑点沿树突 (synapsin-1 punctae along dendrites) 的密度。Crebinostat 可调节染色质介导的神经可塑性,增强小鼠的记忆。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化,并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。 | |||
T64247 | CREB-IN-1 TFA | ||
CREB-IN-1 TFA 是一种有效的、口服具有活力的 CREB 抑制剂,其 IC50 值为 0.18 μM。CREB-IN-1 TFA 对乳腺癌细胞的生长表现出抑制作用。 | |||
T21131 |
NASTRp
Naphthol AS-TR phosphate |
||
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. | |||
T28867 |
STF-038533
|
||
STF-038533 is an inhibitor of CREB target gene transcription. | |||
T70736 |
NSC-45576
|
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NSC-45576 is an inhibitor of CREB-CRE interaction. | |||
T24501 |
MS2126
NSC 71584,NSC71584,MS 2126,MS-2126,NSC-71584 |
||
MS2126 is a Human p53 and CREB Binding Protein interaction inhibitor. | |||
T24606 |
PDE7 inhibitor S14
PDE7 inhibitor-S14,S14 |
||
PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway. | |||
T61314 | DC-CPin7 | ||
DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1]. | |||
T63041 | DS01080522 | ||
DS01080522 是一种 PRKACA 的抑制剂。DS01080522 对 PRKACA 激酶的活性 (IC50: 0.8 nM) 以及 CREB 磷酸化 (IC50: 66 nM) 具有抑制作用。DS0108052 能够用于研究癌症。 | |||
T61719 |
DC-CPin711
|
||
DC-CPin711, a potent and selective inhibitor of the bromodomain of CREB-binding protein (CBP) with an IC50 of 0.0626 μM, effectively halts the cell cycle at the G1 phase and promotes apoptosis [1]. | |||
T76597 |
Prolylserine
|
||
Prolylserine 是一种二肽,是 Mel-Ab 细胞中黑色素生成的抑制剂。Prolylserine 降低小眼相关转录因子 (MITF) 和酪氨酸酶的表达,诱导ERK 的磷酸化,但不诱导 cAMP 反应元件结合蛋白 (CREB)。 | |||
T35818 |
CAY10669
|
||
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY10669 can dose-dependently inhibit histone H4 acetylation in HepG2 cells in vitro. | |||
T61617 | Hcyb1 | ||
Hcyb1 is a potent and specific inhibitor of phosphodiesterase 2 (PDE2). It exhibits a high degree of selectivity for inhibiting PDE2A with an IC50 value of 0.57 μM. In addition, Hcyb1 displays over 250-fold selectivity against other recombinant members of the PDE family. Moreover, its pharmacological actions include neuroprotective and antidepressant-like effects, which are believed to be mediated through the cAMP/cGMP-CREB-BDNF signaling pathway [1]. | |||
T65994 |
(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
|
||
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation... | |||
T75944 |
Spadin TFA
|
||
Spadin TFA 是一种从血液中释放的前肽衍生的天然肽,是一种有效的 TREK-1 通道阻滞剂,其 IC50值为 10 nM。Spadin TFA 增强小鼠中缝背核 5-HT 神经传递,诱导海马 CREB 激活和神经发生。Spadin TFA 可用于抗抑郁研究。 | |||
T21795 |
CRT5
|
||
CRT5 是一种吡嗪苯甲酰胺,对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3 的 IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂,并且 CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1516 |
Curcumin
Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow |
Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology |
Curcumin (Natural Yellow 3) 属于酚类天然产物,是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM),具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。 | |||
T75554 | 6-O-Isobutyrylbritannilactone | ||
6-O-Isobutyrylbritannilactone 是一种天然的黑素生成抑制剂。6-O-Isobutyrylbritannilactone 是一种倍半萜,可从英菊花中分离得到。6-O-Isobutyrylbritannilactone 抑制 IBMX 诱导 B16F10 细胞产生黑色素。6-O-Isobutyrylbritannilactone 也调控 ERK、PI3K/AKT 和 CREB,在斑马鱼胚胎模型中显示出抗黑色素原活性。 |