首页工具

登录

搜索结果

Search Results for " ckd "

23

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T13278	Valecobulin hydrochloride CKD-516 hydrochloride	Microtubule Associated	Cytoskeletal Signaling
	Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂。Valecobulin hydrochloride 对β-微管蛋白聚合有强效的抑制作用，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
T27841	Lobeglitazone Sulfate CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD	Immunology/Inflammation; NF-κB
	Lobeglitazone Sulfate（CKD-501 Sulfate）是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。
T7551	Belotecan hydrochloride CKD-602	Topoisomerase	DNA Damage/DNA Repair
	Belotecan hydrochloride (CKD-602) 是一种合成的水溶性喜树碱衍生物和拓扑异构酶 I 抑制剂，具有潜在的抗肿瘤活性。
T27033	CKD-712 CKD 712,CKD712
	CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and C
T36700	CKD 602
	Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
T14976	CKD-519	Others	Others
	CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).
T28945	Tenofovir disoproxil aspartate CKD-390,CKD390,CKD 390
	Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
T13278L	Valecobulin CKD-516	Others	Others
	Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.
T19871	Beloranib CKD-732,ZGN 440
	Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.
T69011	Lobeglitazone
	Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
T8494	NS-3-008 hydrochloride NS-3-008 HCl	Others	Others
	NS-3-008 hydrochloride (NS-3-008 HCl) 是一种口服具有活性的G0s2转录抑制剂(IC50:2.25 μM)。它可用于慢性肾脏疾病的研究。
T16708	R-268712	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。
T71845	Lockdown
	Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F knockout cells. Lockdown acts in a dose-dependent, allosteric manner with high selectivity for PPM1F
T30479	Bis-T-23 Bis T-23,Bis-T 23,AG1717	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bis-T-23是一种肌动蛋白依赖性达纳敏低聚物的促进剂，是一种 HIV-I 整合酶抑制剂，是泰尔普斯丁衍生物。Bis-T-23可以促进肌动蛋白依赖性的dynamin 寡聚化。Bis-T-23可用于HIV 和慢性肾脏疾病（CKD）的研究。
T13604	CDDO-dhTFEA	Others; NF-κB; Nrf2	Immunology/Inflammation; NF-κB; Others
	CDDO-dhTFEA 是合成的齐墩果烷三萜化合物，可有效激活Nrf2并抑制促炎转录因子NF-κB。它可以恢复高血压 (MAP)，提高 Nrf2 及其靶基因的表达，抑制 NF-κB 的活化和转化生长因子-β 途径，并减少慢性肾病 (CKD) 大鼠的肾小球硬化，间质纤维化和炎症。
T12823	S516	Microtubule Associated	Cytoskeletal Signaling
	S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
T62435	Belotecan
	Belotecan (CKD-602 free base) 是一种 DNA topoisomerase I 抑制剂。Belotecan 能够阻滞细胞周期，并诱导细胞凋亡。Belotecan 是一种具有抗肿瘤作用的喜树碱衍生物，能够用于研究癌症。
T78513	Sodium zirconium cyclosilicate	Others	Others
	Sodium zirconium cyclosilicate 是一种新型口服、不吸收的无机微孔硅酸盐锆化合物，高选择性地作为阳离子交换剂，专门用于去除体内过量的K+。该化合物适用于慢性肾脏疾病（CKD）的研究。
T39410	Zevaquenabant (S)-MRI-1867
	Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).
T73332	BI-685509
	BI-685509 是一种口服有效的sGC 激活剂。BI-685509 可恢复环磷酸鸟苷 (cGMP) 并改善一氧化氮 (NO) 通路的功能。BI-685509 可用于慢性肾病 (CKD) 和糖尿病肾病 (DKD) 的研究。
T69294	UK‑396082
	UK-396082为一有效的TAFI抑制剂，能增进纤溶酶活性并促使ECM水平下降，适用于CKD研究。
T76947	Ziltivekimab
	Ziltivekimab (COR-001) 是一种人源化抗IL-6单克隆抗体，具有降低血清CRP的效能，并展现出抗炎活性。该化合物在CKD相关的慢性全身性炎症及心血管疾病研究中有潜在应用。
T62589	TRPC5-IN-4
	TRPC5-IN-4 是一种有效且安全的TRPC 抑制剂，对TRPC5和TRPC4的IC50分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。

化合物

Valecobulin hydrochloride

Cat.No: T13278

Synonym: CKD-516 hydrochloride

Target: Microtubule Associated

Lobeglitazone Sulfate

Cat.No: T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: NOD

Belotecan hydrochloride

Cat.No: T7551

Synonym: CKD-602

Target: Topoisomerase

Cat.No: T27033

Synonym: CKD 712,CKD712

Cat.No: T36700

Cat.No: T14976

Target: Others

Tenofovir disoproxil aspartate

Cat.No: T28945

Synonym: CKD-390,CKD390,CKD 390

Cat.No: T13278L

Synonym: CKD-516

Target: Others

Cat.No: T19871

Synonym: CKD-732,ZGN 440

Cat.No: T69011

NS-3-008 hydrochloride

Cat.No: T8494

Synonym: NS-3-008 HCl

Target: Others

Cat.No: T16708

Target: ALK, TGF-beta/Smad

Cat.No: T71845

Cat.No: T30479

Synonym: Bis T-23,Bis-T 23,AG1717

Target: HIV Protease

Cat.No: T13604

Target: Others, NF-κB, Nrf2

Cat.No: T12823

Target: Microtubule Associated

Cat.No: T62435

Sodium zirconium cyclosilicate

Cat.No: T78513

Target: Others

Cat.No: T39410

Synonym: (S)-MRI-1867

Cat.No: T73332

Cat.No: T69294

Cat.No: T76947

Cat.No: T62589

Cat. No.	Product Name	Target	Signaling Pathways
T8181	Poricoic acid A Poricoic acid A(F),茯苓新酸 A	Others	Others
	Poricoic acid A (Poricoic acid A(F)) 是提取于 Poria cocos 中，拥有抗肿瘤作用。它通过调节Gas6/AxlNFκB/Nrf2 轴提高AKI-to-CKD 的褪黑激素抑制。
T21977	p-Cresyl sulfate	Others	Others
	p-Cresyl Sulfate 是主要的尿毒症毒素，存在于慢性肾病患者的血液，来源于肝脏中酪氨酸和苯丙氨酸的代谢物。

天然产物

Poricoic acid A

Cat.No: T8181

Synonym: Poricoic acid A(F),茯苓新酸 A

Target: Others

p-Cresyl sulfate

Cat.No: T21977

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼