首页工具

登录

搜索结果

Search Results for " c. albicans "

52

抑制剂 & 化合物

28

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T8536	Filastatin	Antifungal	Microbiology/Virology
	Filastatin 是一种长效的白色念珠菌丝状体抑制剂，具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附，从酵母到菌丝的形态转变，抑制菌丝特异性 HWP1 启动子。
T22387	NSC 55655 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione	Others	Others
	NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。
T2305	Isavuconazole 艾沙康唑,BAL-4815,RO-0094815	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Isavuconazole (RO-0094815) 是一种三唑类前药，对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成，导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。
T4040	AN2718	Antifungal	Microbiology/Virology
	AN2718 通过 OBORT 机制抑制蛋白质合成，有抗真菌功效。
T71939	PS77
	PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
T35700	FR901379
	FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR901379 is protective against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of pulmonary cysts and trophozoites in a mouse model of P. carinii infection. \|1. Fujie, A., Iwamoto, T., Sato, B., et al. FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and bi...
T36434	Sordarin sodium
	Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It...
T80293	RP-1
	RP-1为一抗菌肽，具备针对S. aureus、S. typhimurium、E. coli及C. albicans的抗菌活性。
T63802	Antifungal agent 35
	Antifungal agent 35 是一种使氟康唑对C. albicans 的抗真菌活性的有效增强剂，是有效的抗真菌剂。
T76264	Nisin Z
	Nisin Z 是一种抗菌和抗炎肽。Nisin Z 可有效对抗革兰氏阳性菌和真菌 (fungi)，例如 C. albicans。
T74272	Antifungal agent 84
	Antibacterial agent 84 是一种抗真菌化合物。Antibacterial agent 84 以 CNB1 依赖性方式抑制念珠菌。Antibacterial agent 84 抑制C. albicans 生物膜的活性。
T36533	SCH 725674
	SCH 725674 is an antifungal macrolide originally isolated from Aspergillus. It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).
T36437	Sphinganine (d17:0) Sphinganine (d17:0)
	Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
T36054	D13
	D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. \|1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).
T80629	2-Dodecanol
	2-Dodecanol有效抑制了C. albicans的菌丝形成和SIR2基因的表达。
T83715	Histatin 3 TFA Hst-3
	Histatin 3, 一种唾液抗菌肽，对C. albicans具有活性（LC50 = 9.2 µM）。在12 µM浓度下，还能在无细胞测定中诱导肌动蛋白聚合。
T80407	Peptide 5g
	Peptide 5g 是一种具有广谱抗菌特性的化合物。它对 E. coli, S. aureus 和 C. albicans 的最小抑制浓度 (MIC) 值显著，分别为 30 μg/mL、10 μg/mL 和 12.5 μg/mL。
T61308	Antifungal agent 27
	Antifungal agent 27 (compound 7) is a chemical compound possessing antifungal properties. It exhibits moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg/mL, respectively [1].
T74273	Antifungal agent 52
	Antifungal agent 52 (compound 6c) 是四唑衍生物。Antifungal agent 52 抑制麦角固醇的合成。Antifungal agent 52 对白色念珠菌表现出显着的抗真菌活性 Antifungal agent 52 影响白色念珠菌基底细胞膜通透性。
T37730	Saccharocarcin A
	Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.
T74956	Chitin synthase inhibitor 10
	Chitin synthase inhibitor 10为一种高效的几丁质合酶(CHS)抑制剂，具有0.11 mM的IC50，表现出显著的CHS抑制活性。作为抗真菌剂，该化合物对包括C. albicans和C. neoformans在内的耐药真菌变体有效，适合用于侵袭性真菌感染(IFI)研究。
T80400	Peptide 5e
	Peptide 5e为一种具有抗菌特性的肽类化合物。其针对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)以及白色念珠菌(C. albicans)的最小抑制浓度(MIC)值依次为30、5及25 μg/mL。
T80365	Maximin H39
	Maximin H39为一种抗菌肽，对C. albicans、S. aureus、B. subtilis展示抗菌活性（MIC: 9.4, 9.4, 18.8 μg/mL），且对人类及兔子红细胞具溶血活性。
T80369	Maximin 68
	Maximin 68为抗菌肽，其对C. albicans、S. aureus、E. coli、B. subtilis显示出抗菌活性（MIC分别为18.8、9.4、37.5、9.4 μg/mL），并对人和兔红细胞表现出溶血活性。
T83689	Histatin 8 TFA Hst-8
	Histatin 8是一种唾液抗微生物肽，是histatin 3和histatin 5的蛋白水解片段。针对A. baumannii（包括对colistin敏感或耐药的菌株）在32 µg/ml浓度下显示活性。Histatin 8也对C. albicans和C. tropicalis显示活性（MICs分别为1和5 mg/ml）。
T63077	Chitin synthase inhibitor 12
	Chitin synthase inhibitor 12 是一种几丁质合酶 (CHS) 抑制剂，具有优异的 CHS 抑制作用 (IC50: 0.16 mM)。Chitin synthase inhibitor 12 也是一种广谱抗真菌剂，对耐药真菌变体（如 C. albicans、C. neoformans）具有抗性。Chitin synthase inhibitor 12 能够用于研究侵袭性真菌感染 (IFIs)。
T83699	LL-37 (18-37) (human) TFA KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39
	LL-37 (18-37) 是 LL-37 的一种抗菌肽片段。对S. aureus和C. albicans具有活性，最小致死浓度分别为4 µM 和10 µM。在10到50 µM 的浓度范围内，它还能抑制E. histolytica营养体的生长。
T80340	ROAD-1
	ROAD-1是一种α-防御素，源于恒河猴口腔粘膜。该化合物展现出对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抗菌活性。
T38044	Reveromycin B
	Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans (MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C , reveromycin B does not inhibit proliferation of KB and K562 cells.
T80367	Maximin 78
	Maximin 78为一种具有广谱抗菌性能的肽类化合物。该化合物展现出针对C. albicans、S. aureus、B. subtilis的显著抗菌活性，最小抑菌浓度（MIC）分别为37.5、4.7、37.5 μg/mL。此外，Maximin 78对人类和兔子红细胞显示出溶血活性。
T37423	Reveromycin D
	Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively).
T60965	Anticandidal agent-1
	Anticandidal agent-1 (化合物 c2) 是有效的广谱抗念珠菌剂，可通过阻断菌丝伸长和丝化来抑制生物膜。Anticandidal agent-1 对光滑念珠菌和白念珠菌具有抗念珠菌活性，MIC50值分别为 13.51 和 8.65 μg/mL。
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T35423	7-oxo Staurosporine
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr...
T36336	Burnettramic Acid A
	Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic aci...
T37750	Benanomicin B (formate)
	Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans, andP. oryzae(MICs = 1.56-50 μg/ml).1Benanomicin B inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B from an act...
T37749	Benanomicin A
	Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans,P. oryzae, andA. niger(MICs = 3.13-50 μg/ml).1Benanomicin A inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B fr...
T79467	Antifungal agent 60
	Antifungalagent 60（compound 16）是一种抑制麦角甾醇生物合成的广谱抗真菌剂。它能够有效抑制包括7种人类致病真菌、2种耐氟康唑的白色念珠菌分离株以及2种多重耐药的耳念珠菌分离株。
T71761	Carbazomycin B
	Carbazomycin B is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against a panel of seven fungi and a panel of seven bacteria, as well as P. falciparum and C. albicans. It is also active against a panel of five plant pathogenic fungi. Carbazomycin B is cytotoxic to MCF-7, KB, NCI H187, and Vero cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.5 µM).
T83849	OP-145 TFA acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide,P60.4-Ac
	OP-145是一种合成抗菌肽及抗菌肽LL-37的衍生物。它对E. coli、P. aeruginosa、C. albicans和A. niger具有活性（MICs分别为2、3、6和18 µM）。含有OP-145的聚乳酸-共-聚乙二醇酸（PLGA）微球能够在骨折部位接种细菌后通过外科股骨骨折所诱导的小鼠骨感染模型中防止生物膜的形成。
T35742	IKD-8344
	IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vit...
T80345	Bovine tracheal antimicrobial peptide
	Bovine tracheal antimicrobial peptide，一种自牛气管粘膜分泌的抗菌肽，对E.coliD31、K.pneumoniae13883、S.aureus25923、P.aeruginosa27853 以及C.albicans14053 均展现出显著的抗菌效果，其MIC值分别为12-25、12-25、25-50、25-50、6-12 μg/ml。
T35772	Emestrin
	Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr...
T35671	Salazinic Acid
	Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay...
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...
T37963	Methylchloroisothiazolinone/Methylisothiazolinone Mixture
	Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. 1.Frenzel, E., Schmidt...
T83706	BMAP 28 (bovine) TFA Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28
	BMAP 28是一种合成抗菌肽，对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下，BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下，减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下，对分离的人类红细胞引起溶血，并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率，但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。
T69995	Chlorhexidine-d8 HCl
	Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC...
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...

化合物

Cat.No: T8536

Target: Antifungal

Cat.No: T22387

Synonym: 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione

Target: Others

Cat.No: T2305

Synonym: 艾沙康唑,BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

Cat.No: T4040

Target: Antifungal

Cat.No: T71939

Cat.No: T35700

Sordarin sodium

Cat.No: T36434

Cat.No: T80293

Antifungal agent 35

Cat.No: T63802

Cat.No: T76264

Antifungal agent 84

Cat.No: T74272

Cat.No: T36533

Sphinganine (d17:0)

Cat.No: T36437

Synonym: Sphinganine (d17:0)

Cat.No: T36054

Cat.No: T80629

Cat.No: T83715

Synonym: Hst-3

Cat.No: T80407

Antifungal agent 27

Cat.No: T61308

Antifungal agent 52

Cat.No: T74273

Saccharocarcin A

Cat.No: T37730

Chitin synthase inhibitor 10

Cat.No: T74956

Cat.No: T80400

Cat.No: T80365

Cat.No: T80369

Cat.No: T83689

Synonym: Hst-8

Chitin synthase inhibitor 12

Cat.No: T63077

LL-37 (18-37) (human) TFA

Cat.No: T83699

Synonym: KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39

Cat.No: T80340

Cat.No: T38044

Cat.No: T80367

Cat.No: T37423

Anticandidal agent-1

Cat.No: T60965

Human α-Defensin 6

Cat.No: T80362

7-oxo Staurosporine

Cat.No: T35423

Burnettramic Acid A

Cat.No: T36336

Benanomicin B (formate)

Cat.No: T37750

Cat.No: T37749

Antifungal agent 60

Cat.No: T79467

Cat.No: T71761

Cat.No: T83849

Synonym: acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide,P60.4-Ac

Cat.No: T35742

Bovine tracheal antimicrobial peptide

Cat.No: T80345

Cat.No: T35772

Cat.No: T35671

Diallyl Tetrasulfide

Cat.No: T36057

Synonym: ICD-1585

Methylchloroisothiazolinone/Methylisothiazolinone Mixture

Cat.No: T37963

BMAP 28 (bovine) TFA

Cat.No: T83706

Synonym: Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28

Chlorhexidine-d8 HCl

Cat.No: T69995

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

Cat. No.	Product Name	Target	Signaling Pathways
T1388	Fluconazole 氟康唑,UK-49858	Antibiotic; Antifection; Antifungal	Microbiology/Virology
	Fluconazole (UK-49858) 是一种对多种真菌具有活性的三唑类抗真菌剂，抑制 C. albicans 和 Candida kefyr 的 IC99为 0.20 μg/mL 至 0.39 μg/mL。
T7029	Pseudolaric Acid C	Antifungal	Microbiology/Virology
	Pseudolaric Acid C 是一种从Pseudolarix kaempferiGorden 根皮部中分离的二萜酸，对白色念珠菌有较弱的抗真菌活性。
T37267	Pachybasin	Antibacterial	Microbiology/Virology
	Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性，MIC 值为 64.0 μg/mL，对金黄色葡萄球菌具有抗菌活性和尖孢镰刀菌，MIC 值分别为 32.0 和 16.0 μg/mL。
TN1877	Lonicerin 忍冬苦苷,金银花	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物，对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T4S1321	(+)-Magnoflorine chloride Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine chloride (Escholine chloride) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少 C. albicans 生物膜的形成。
T3S1320	(+)-Magnoflorine iodide Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine iodide (Thalictrine iodide) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少C. albicans 生物膜的形成。
T3S1319	(+)-Magnoflorine Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine (Thalictrin) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，可以减少 C. albicans 生物膜的形成，具有抗真菌、抗氧化、抗糖尿病、镇静和抗焦虑的作用。
T70891	Pyridoxatin
	Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans.
T11895	Luteolin-7-rutinoside	Others	Others
	Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
T79931	Mutanocyclin
	Mutanocyclin 作为一种效能显著的抗真菌剂，能够抑制白色念珠菌 (C. albicans) 的丝状形成，并下调 HWP1、ECE1、FLO8、TEC1 基因的 mRNA 表达水平。此外，Mutanocyclin 在体外小鼠模型中亦能有效抑制酵母形态的发展。
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
TN3709	Coronarin D ethyl ether	NF-κB	NF-κB
	Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.
T37712	Fumiquinazoline D
	Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 μg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 μg/ml, respectively).
T37444	Aranorosin
	Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
T36403	Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate
	Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).
TN3723	Cryptomeridiol	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.
T80330	XT-1
	XT-1是一种抗菌肽，源自热带爪蟾Xenopus tropicalis的皮肤分泌物，表现出对S.aureus、E.coli和C.albicans的强烈活性，其最小抑菌浓度(MIC)分别为5μM、6μM和50μM。
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...
TN3708	Coronarin D	BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
T36886	Pestalotin
	Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
TN4471	Lysicamine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...

天然产物

Cat.No: T1388

Synonym: 氟康唑,UK-49858

Target: Antibiotic, Antifection, Antifungal

Pseudolaric Acid C

Cat.No: T7029

Target: Antifungal

Cat.No: T37267

Target: Antibacterial

Cat.No: TN1877

Synonym: 忍冬苦苷,金银花

Target: Apoptosis, Antibacterial

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

(+)-Magnoflorine chloride

Cat.No: T4S1321

Synonym: Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

(+)-Magnoflorine iodide

Cat.No: T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide

Target: Others, Antifungal

(+)-Magnoflorine

Cat.No: T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱

Target: Others, Antifungal

Cat.No: T70891

Luteolin-7-rutinoside

Cat.No: T11895

Target: Others

Cat.No: T79931

Cat.No: TN3978

Target: Antifection

Coronarin D ethyl ether

Cat.No: TN3709

Target: NF-κB

Fumiquinazoline D

Cat.No: T37712

Cat.No: T37444

Cat.No: T38016

Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

Cat.No: T36403

Cat.No: TN3723

Target: PAFR, Antifection

Cat.No: T80330

Antibacterial synergist 2

Cat.No: T72235

Cat.No: TN5014

Target: Antifection, HSV

Cat.No: T37008

Cat.No: TN3708

Target: BCL, c-Myc, TNF, NF-κB, Caspase, COX, Antifection

Cat.No: T36886

Cat.No: T36329

Cat.No: T83693

Synonym: MG2

Cat.No: TN4471

Target: IL Receptor, Antifection

Cat.No: T36438

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼