Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0030L |
Bupivacaine
AH 250,AH-250,AH250,Bupivacaina,Exparel,Anekain |
NMDAR | Neuroscience |
Bupivacaine (AH-250) 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道,IC50 为 69.5 μM。Bupivacaine 可用于慢性疼痛的研究。 | |||
T0030 |
Bupivacaine hydrochloride
Vivacaine,Bupivacaine HCl,盐酸布比卡因 |
Sodium Channel | Membrane transporter/Ion channel |
Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂,可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道,还阻断SCN5A 通道,IC50为 69.5 μM。 | |||
T6566 |
Levobupivacaine hydrochloride
Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) 是有效的钠通道阻滞剂。 | |||
T80641 |
Bupivacaine hydrochloride monohydrate
|
Potassium Channel; Calcium Channel; Sodium Channel; NMDAR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Bupivacaine hydrochloride monohydrate 是一种 NMDA 受体抑制剂,对钠、L-钙和钾通道有抑制作用。Bupivacaine hydrochloride monohydrate 对 SCN5A 通道有抑制作用,常用于研究慢性疼痛。 | |||
T70224 |
Bupivacaine tartrate
|
||
Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells. | |||
T70223 |
UA8967
|
||
UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12–61 μM for exposure times of 72 h. There was also no selective inhibition of DNA, RNA or protein synthesis after exposure to UA8967. UA8967 is observed to affect the plasma membrane. | |||
T1697 |
debutylbupivacaine
|
Others | Others |
Debutylbupivacaine 是 ropivacaine hydrochloride 和 bupivacaine 的中间体。 | |||
T1787 |
Levobupivacaine
|
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。 | |||
T1144 |
Lidocaine hydrochloride
Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin |
Apoptosis; ERK; NF-κB; MEK; Sodium Channel | Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB |
Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。 | |||
T70538 |
PD-85639
|
||
PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membr... |