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Search Results for " betulin "

15

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37781	2,3-Indolobetulin
	2,3-Indolobetulin is a pentacyclic triterpenoid and derivative of betulin .1It has been used in the synthesis of α-glucosidase inhibitors. 1.Khusnutdinova, E.F., Smirnova, I.E., Kazakova, O.B., et al.Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitorsMed. Chem. Res.262732-2742(2017)
T38088	28-Deoxybetulin methyleneamine
	28-Deoxybetulin methyleneamine is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It has been used in the synthesis of triterpene derivatives with antiviral activity. 1.Nitz, T.J., Montalbetti, C., Mears, R., et al.Extended Triterpene Derivatives(2008)
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2
T35686	3-Acetyl Betulinaldehyde
	3-Acetyl betulinaldehyde is a triterpene and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inA. japonica.1It is an intermediate in the synthesis of 3-acetylbetulinic acid, as well as various lupine and germanicane triterpenes and saponins with anticancer activity.2 1.Tung, N.H., Kwon, H.-J., Kim, J.-H., et al.An anti-influenza component of the bark of Alnus japonicaArch. Pharm. Res.33(3)363-367(2010) 2.Thibeault, D., Gauthier, C., Legault, J., et al.Synthesis a...
T36318	28-Acetylbetulin
	28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found inM. chiapensisand has anti-inflammatory and anticancer activities.1,2It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 μM, respectively).128-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.3...
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T35678	2,3-Indolobetulinic glycine amide
	2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)
T31466	Dihydrobetulinic acid
	Dihydrobetulinic acid is a bioactive chemical.
T40328	Betulinic acid derivative-1
	Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.
T37038	Betulinic Acid propargyl ester
	Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives.
T33334	Methyl acetyl betulinate
	Methyl acetyl betulinate is a bioactive chemical.
T131503	Betulinic acid (Mairin; Gratiolone; Platanol)
	Betulinic acid (Mairin; Gratiolone; Platanol) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131503。
T27464	GSK2565363C
	GSK2565363C is a betulin derivative wth antitumor activity.
T27465	GSK2578999A
	GSK2578999A is a betulin derivative with antitumor activity.
T69244	Betulonaldehyde
	Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively). Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in t...

化合物

2,3-Indolobetulin

Cat.No: T37781

28-Deoxybetulin methyleneamine

Cat.No: T38088

Betulinic Aldehyde oxime

Cat.No: T37039

3-Acetyl Betulinaldehyde

Cat.No: T35686

28-Acetylbetulin

Cat.No: T36318

3-Oxobetulin Acetate

Cat.No: T70856

2,3-Indolobetulinic glycine amide

Cat.No: T35678

Dihydrobetulinic acid

Cat.No: T31466

Betulinic acid derivative-1

Cat.No: T40328

Betulinic Acid propargyl ester

Cat.No: T37038

Methyl acetyl betulinate

Cat.No: T33334

Betulinic acid (Mairin; Gratiolone; Platanol)

Cat.No: T131503

Cat.No: T27464

Cat.No: T27465

Betulonaldehyde

Cat.No: T69244

Cat. No.	Product Name	Target	Signaling Pathways
T3121	Betulin Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇	Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase	Apoptosis; Metabolism
	Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜，是 SREBP 抑制剂。
TN3510	Betulin palmitate	Others	Others
	Betulin palmitate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3510，CAS号为 582315-55-7。
TN3509	Betulin caffeate	Others	Others
	Betulin-3β-caffeate shows moderate antioxidant activity with IC50 value 108.0 ug/ml.
T20990	Betulin diacetate
	Betulin diacetate is a bioactive chemical.
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
T3S2152	23-Hydroxybetulinic acid Anemosapogenin,23-羟基白桦酸	Others	Others
	23-Hydroxybetulinic acid (Anemosapogenin) 是一种具有抗癌作用的生物化合物。
T2S0765	Epibetulinic acid	NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用，IC50分别为 0.7 和 0.6 μM，具有抗炎活性。
T3796	Betulinaldehyde Betulinic aldehyde,Betulinal,Betunal,白桦脂醛	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Betulinaldehyde (Betunal) 是五环三萜，有抗金黄色葡萄球菌等细菌和真菌作用。
TN1442	Betulinic acid methyl ester	Antifection	Microbiology/Virology
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN2972	3-O-(E)-p-Coumaroylbetulin	Others	Others
	3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM.
TN2814	23-Hydroxybetulin	Others	Others
	23-Hydroxybetulin is a natural product from Betula alba L.
TN5987	Betulinic acid palmitate
	Betulinic acid palmitate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5987，CAS号为 19833-15-9。
TN2446	3-Oxobetulin Betulone	Antiviral	Immunology/Inflammation
	Betulone is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.
TN2280	Trametenolic acid	Tyrosinase	Proteases/Proteasome
	Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP

天然产物

Cat.No: T3121

Synonym: Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇

Target: Apoptosis, Endogenous Metabolite, Lipid, Fatty Acid Synthase

Betulin palmitate

Cat.No: TN3510

Target: Others

Betulin caffeate

Cat.No: TN3509

Target: Others

Betulin diacetate

Cat.No: T20990

Betulinic acid

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

23-Hydroxybetulinic acid

Cat.No: T3S2152

Synonym: Anemosapogenin,23-羟基白桦酸

Target: Others

Epibetulinic acid

Cat.No: T2S0765

Target: NO Synthase, Prostaglandin Receptor

Betulinaldehyde

Cat.No: T3796

Synonym: Betulinic aldehyde,Betulinal,Betunal,白桦脂醛

Target: Apoptosis, Antibacterial

Betulinic acid methyl ester

Cat.No: TN1442

Target: Antifection

3-O-(E)-p-Coumaroylbetulin

Cat.No: TN2972

Target: Others

23-Hydroxybetulin

Cat.No: TN2814

Target: Others

Betulinic acid palmitate

Cat.No: TN5987

Cat.No: TN2446

Synonym: Betulone

Target: Antiviral

Trametenolic acid

Cat.No: TN2280

Target: Tyrosinase

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

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