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Cat. No. | Product Name | Target | Signaling Pathways |
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T22240 |
Amitriptyline
|
Sigma receptor; 5-HT Receptor; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Amitriptyline 是一种具有镇痛特性的三环类抗抑郁药 (TCA)。它广泛用于治疗抑郁症和神经性疼痛。 | |||
T0678 |
Amitriptyline hydrochloride
Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin |
Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂,还与多巴胺再摄取转运体结合,其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂,具有强神经营养活性和有抗抑郁作用。 | |||
T70261 |
Amitriptyline Embonate
|
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Amitriptyline Embonate is an inhibitor of the re-uptake of norepinephrine and serotonin, thereby inhibiting N-methyl-D-aspartate (NMDA) receptors. | |||
T35292 |
Z-10-Hydroxyamitriptyline
|
||
Z-10-Hydroxyamitriptyline 是抗抑郁化合物 amitriptyline 的外消旋醇代谢产物,可从患者尿液中排出。 | |||
T0559 |
Dibenzosuberone
|
Others | Others |
Dibenzosuberone 是医药中间体,用于合成药物阿米替林。 | |||
T1327 |
Nortriptyline hydrochloride
Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林 |
Apoptosis; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor; Drug Metabolite | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药,用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物,是有效自噬抑制剂。 | |||
T25047 |
Alfetamine
alpha-allyl-phenethylamine |
||
Alfetamine is a chemical compound of the phenethylamine family. It is similar to imipramine and amitriptyline, two tricyclic antidepressants. | |||
T38131 | (E)-10-Hydroxynortriptyline | ||
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ... | |||
T11135 |
(E)-10-Hydroxynortriptyline maleate
(E)-10-Hydroxy Nortriptyline maleate |
Others | Others |
(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms. | |||
T11008 |
Desmethylnortriptyline
|
Others | Others |
Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is used to relieve depressive symptoms. | |||
T36521 |
Alaproclate (hydrochloride)
|
||
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73844 | Nortriptyline | ||
Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。 |