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Search Results for " acetyl coenzyme a "

21

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T73805	Acetyl coenzyme A
	Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。
T37958	Acetyl Coenzyme A trisodium Acetyl-CoA trisodium	OXPHOS; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism
	Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) 是糖代谢和脂代谢的重要化合物，参与三羧酸循环。
T3510	Olumacostat Glasaretil	Acetyl-CoA Carboxylase	Metabolism
	Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。
T5046	Haloxyfop Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵	Others; Acetyl-CoA Carboxylase	Metabolism; Others
	Haloxyfop (Haloxyfop Acid) 是有效的芳氯氧苯氧丙酸除草剂，广泛应用于阔叶作物的野草。对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 具有抑制作用，IC50为 0.5 μM，而对豌豆中该酶无影响。
TQ0243	ND-646	Acetyl-CoA Carboxylase	Metabolism
	ND-646 是乙酰辅酶 A 羧化酶（ACC）抑制剂，对重组 hACC1 和 hACC2的IC50分别为 3.5 nM 和 4.1 nM。
T7163	PF-05175157	Acetyl-CoA Carboxylase	Metabolism
	PF 05175157 是一种广谱的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，对 ACC1 (human)，ACC2 (human)， ACC1 (rat) 和 ACC2 (rat) 具有抑制作用，IC50分别为 27.0, 33.0, 23.5 和 50.4 nM。
T1889	CP-640186 CP 640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。
T14991	CMS-121 CMS121	Acetyl-CoA Carboxylase	Metabolism
	CMS-121 是喹诺酮衍生物，对乙酰辅酶 A 羧化酶 1 具有抑制作用，具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性，EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎，抗氧化，神经保护和肾保护作用。
T3988	TOFA MDL14514,RMI14514	Acetyl-CoA Carboxylase	Metabolism
	TOFA (MDL14514) 是有效的乙酰辅酶 A 羧化酶-α (ACCA)的变构抑制剂。
T3622	CP-640186 hydrochloride CP 640186 HCl,盐酸CP-640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
T7184	Firsocostat ND-630,NDI-010976,GS-0976	Acetyl-CoA Carboxylase	Metabolism
	Firsocostat (GS-0976) 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂，抑制人类 ACC1 和 ACC2 的IC50分别为2.1和6.1 nM。
T73796	Acetyl coenzyme A lithium
	Acetyl-coenzyme A (Acetyl-CoA) lithium 是一种膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A lithium 通过向目标氨基酸残基提供乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A lithium 也是脂质合成的关键前体。
T8754	CPD2028	Others	Others
	CPD2028 是ND630的中间体。ND-630 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂。
T73054	Moiramide B	Acetyl-CoA Carboxylase; Antibiotic	Metabolism; Microbiology/Virology
	Moiramide B 是一种高效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂（IC50:6 nM),具有抗菌活性，强烈抑制革兰氏阳性菌，但对革兰氏阴性菌的抑制效果较弱。
T20620	Clethodim RE45601,Prism,Trigger,RE-45601,Centurion,RE 45601
	Clethodim is a acetyl-coenzyme A carboxylase (ACCase)-inhibiting cyclohexanedione herbicide.
T38473	Malonyl Coenzyme A lithium
	Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
T32598	Lauroyl-coenzyme A Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa
	Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport.
T76124	Acyl coenzyme A synthetase
	Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。
T62418	hACC2-IN-1
	hACC2-IN-1 是一种乙酰辅酶 A 羧化酶 2 (ACC2) 的有效抑制剂，对 hACC2 的 IC50 值为 2.5 μM。hACC2-IN-1 具有潜力进行肥胖的研究。
T73918	Lauroyl coenzyme A lithium
	Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体，即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A，用作脂质代谢的中间体，参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。
T36827	Acetoacetyl Coenzyme A (sodium salt hydrate) Acetoacetyl-CoA
	Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5]

化合物

Acetyl coenzyme A

Cat.No: T73805

Acetyl Coenzyme A trisodium

Cat.No: T37958

Synonym: Acetyl-CoA trisodium

Target: OXPHOS, Endogenous Metabolite, Autophagy

Olumacostat Glasaretil

Cat.No: T3510

Target: Acetyl-CoA Carboxylase

Cat.No: T5046

Synonym: Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵

Target: Others, Acetyl-CoA Carboxylase

Cat.No: TQ0243

Target: Acetyl-CoA Carboxylase

Cat.No: T7163

Target: Acetyl-CoA Carboxylase

Cat.No: T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

Cat.No: T14991

Synonym: CMS121

Target: Acetyl-CoA Carboxylase

Cat.No: T3988

Synonym: MDL14514,RMI14514

Target: Acetyl-CoA Carboxylase

CP-640186 hydrochloride

Cat.No: T3622

Synonym: CP 640186 HCl,盐酸CP-640186

Target: Acetyl-CoA Carboxylase

Cat.No: T7184

Synonym: ND-630,NDI-010976,GS-0976

Target: Acetyl-CoA Carboxylase

Acetyl coenzyme A lithium

Cat.No: T73796

Cat.No: T8754

Target: Others

Cat.No: T73054

Target: Acetyl-CoA Carboxylase, Antibiotic

Cat.No: T20620

Synonym: RE45601,Prism,Trigger,RE-45601,Centurion,RE 45601

Malonyl Coenzyme A lithium

Cat.No: T38473

Lauroyl-coenzyme A

Cat.No: T32598

Synonym: Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa

Acyl coenzyme A synthetase

Cat.No: T76124

Cat.No: T62418

Lauroyl coenzyme A lithium

Cat.No: T73918

Acetoacetyl Coenzyme A (sodium salt hydrate)

Cat.No: T36827

Synonym: Acetoacetyl-CoA

Cat. No.	Product Name	Target	Signaling Pathways
T5287	N-Acetyl-L-aspartic acid AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-aspartic acid (AC-ASP-OH) 是天冬氨酸的衍生物，是由氨基酸天冬氨酸和乙酰辅酶 A 在神经元中合成的。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
TN1751	Hydroxycitric acid	ERK; p38 MAPK; Fatty Acid Synthase	MAPK; Metabolism
	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.

天然产物

N-Acetyl-L-aspartic acid

Cat.No: T5287

Synonym: AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸

Target: Others, Endogenous Metabolite

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Hydroxycitric acid

Cat.No: TN1751

Target: ERK, p38 MAPK, Fatty Acid Synthase

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