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30

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39675	ALDH1A2-IN-1 ALDH1A2-IN-1
	ALDH1A2-IN-1 is a reversible inhibitor of the active site of ALDH1A2, showing a significant affinity for the enzyme with an IC50 value of 0.91 μM and a Kd value of 0.26 μM. This compound interacts hydrophobically with the enzyme, contributing to its inhibitory properties.
T67832	ALDH2 modulator 1	Dehydrogenase	Metabolism
	ALDH2 modulator 1 是一种有效的且具有口服活性的乙醛脱氢酶-2 （ALDH2）调节剂。ALDH2 modulator 1 可使小鼠血液中的酒精含量降低。
T10140	4-Diethylaminobenzaldehyde	Dehydrogenase	Metabolism
	4-Diethylaminobenzaldehyde 是醛脱氢酶(ALDHs)的可逆抑制剂，对 ALDH1 的 Ki 为 4 nM，具有较强的抗雄激素作用，IC50为1.71 μM。
T12196	NCT-505	Dehydrogenase	Metabolism
	NCT-505是乙醛脱氢酶的选择性抑制剂，IC50为 7 nM。对 hALDH1A2，hALDH1A3，hALDH2，hALDH3A1的抑制作用较弱，IC50分别为 >57，22.8，20.1，>57 μM。
T64347	ALDH1A3-IN-3	Dehydrogenase	Metabolism
	ALDH1A3-IN-3 (化合物 16) 是一种有效的 ALDH1A3 抑制剂，IC50 值为 0.26 μM。ALDH1A3-IN-3 也是 ALDH3A1 的底物。ALDH1A3-IN-3 可用于前列腺癌的研究。
T6903	NCT-501 NCT501	Dehydrogenase	Metabolism
	NCT-501 是一种茶碱类化合物，有效抑制醛脱氢酶 1A1(ALDH1A1), 抑制 hALDH1A1 IC50为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时,IC50值 >57 UM)。
T2662	Alda-1 Alda 1	Apoptosis; Dehydrogenase	Apoptosis; Metabolism
	Alda-1是一种 ALDH2 激动剂，是野生型 ALDH21 和亚洲 E487K 突变体 ALDH22 形式的线粒体醛脱氢酶 2 的细胞渗透激活剂。
T63341	ALDH1A1-IN-2	Dehydrogenase	Metabolism
	ALDH1A1-IN-2 是一种有效的醛脱氢酶 1a1 (aldh1a1) 抑制剂，具有抗癌活性。ALDH1A1-IN-2 可用于研究乳腺癌、炎症或肥胖症。
T60372	ALDH3A1-IN-1
	ALDH3A1-IN-1 (Compound 18) 是一种有效的ALDH3A1抑制剂，IC50为 1.61 μM。ALDH3A1-IN-1 比 DEAB 更有效地对抗患者来源的原发性前列腺肿瘤上皮细胞，无论是作为单药或与多西紫杉醇联合治疗。
T60240	ALDH1A3-IN-2	Dehydrogenase	Metabolism
	ALDH1A3-IN-2 是一种有效的 ALDH1A3 抑制剂，IC50 为 0.30 μM。ALDH1A3-IN-2 具有癌症疾病研究的潜力。
T23533	WIN 18446	Dehydrogenase	Metabolism
	Win 18446 是口服有效的睾丸特异性的ALDH1a2的抑制剂，IC50为 0.3 μM。Win 18446 抑制睾丸内视黄醇合成视黄酸，可逆的抑制多个物种的精子形成，。
T7835	CM10 CM 10	Dehydrogenase	Metabolism
	CM10是一种有效的乙醛脱氢酶 1A (ALDH1A) 家族选择性抑制剂，对于 ALDH1A1，ALDH1A2 和 ALDH1A3 的IC50分别为 1700、740 和 640 nM。CM 10 可以调节新陈代谢并具有抗癌活性。
T0054	Disulfiram 双硫伦,Tetraethylthiuram disulfide,双硫仑,NSC 190940,TETD	Dehydrogenase; Interleukin; Pyroptosis	Apoptosis; Immunology/Inflammation; Metabolism
	Disulfiram (TETD) 是一种乙醛脱氢酶 ALDH 的抑制剂，抑制 hALDH1 和 hALDH2 (IC50=0.15/1.45 μM)，具有特异性。Disulfiram 对酒精产生急性敏感性，还可以抑制 GSDMD 孔形成。
T1389	Dyclonine hydrochloride 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl	Sodium Channel; Antibacterial; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。
T15022	CVT-10216 3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸	Dehydrogenase	Metabolism
	CVT-10216 是可逆的、选择性的醛脱氢酶 2（ALDH-2）抑制剂，IC50为 29 nM。对 ALDH-1的抑制作用较弱，IC50为 1.3 μM。它可以减少偏爱酒精的大鼠过量饮酒，并表现出抗焦虑作用。
T60275	ALDH3A1-IN-2
	ALDH3A1-IN-2 (Compound 19) 作为一种高效的ALDH3A1抑制剂，其IC50值达到1.29 μM。由于醛脱氢酶 (ALDH) 在前列腺癌等多种肿瘤类型中的过表达，ALDH3A1-IN-2 显示出其在癌症疾病研究中的应用潜力。
T64228	ALDH1A1-IN-3
	ALDH1A1-IN-3 是一种良好的、选择性的醛脱氢酶 1A1 (ALDH1A1) 抑制剂 (IC50: μM)。ALDH1A1-IN-3 可以有效的改善 HepG2 细胞的葡萄糖消耗。ALDH1A1-IN-3 能够用于进行改善糖代谢的研究。
T60550	ALDH1A3-IN-1
	ALDH1A3-IN-1 (Compound 14) 是有效的 ALDH1A3抑制剂，可用于前列腺癌的研究， (IC50 = 0.63 μM; Ki = 0.46 μM)。
T21567L	Cyclosomatostatin Acetate Cyclosomatostatin Acetate （84211-54-1 Free base）	Somatostatin	GPCR/G Protein
	Cyclosomatostatin Acetate 是有效的生长抑素受体拮抗剂。Cyclosomatostatin Acetate 在直肠癌 (CRC) 细胞中可以抑制 SSTR1的信号传导，并降低结细胞增殖、ALDH+ 细胞群体大小和球形成。
T63081	KS106
	KS106 是一种 ALDH 的有效抑制剂，能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS106 具有抗增殖和抗癌作用，且毒性较低。KS106 可将细胞周期阻滞在G2/M 期，饼诱导细胞凋亡。KS106 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累。
T63992	KS100
	KS100 是 ALDH 的有效抑制剂，能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS100 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累，且具有低毒性的抗增殖和抗癌活性。KS100 能够将细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T69366	CM39
	CM39 is an ALDH inhibitor. Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and in chemoresistance.
T60363	Nitrefazole
	Nitrefazole 是一种4-nitroimidazole 衍生物，对醛脱氢酶(ALDH)具有强烈而持久的抑制作用，醛脱氢酶是一种参与酒精代谢的酶。
T35568	BODIPY-aminoacetaldehyde diethyl acetal
	BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the effl...
T37869	BODIPY aminoacetaldehyde
	BODIPY aminoacetaldehyde (BAAA) is a fluorescent substrate applicable to both murine and human aldehyde dehydrogenase (ALDH). It comprises an aminoacetaldehyde moiety chemically bonded to the BODIPY fluorochrome. BAAA can serve as a labeling tool for stem cells[1].
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as wel...
T75842	Cyclosomatostatin TFA
	Cyclosomatostatin TFA 作为一种有效的生长抑素(SST)受体拮抗剂，在直肠癌(CRC)细胞中通过抑制1型生长抑素受体(SSTR1)的信号传导，有效降低结细胞增殖、ALDH+细胞群体的大小以及球形成。
T39485	NCT-501 hydrochloride
	NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
T76159	Aldehyde dehydrogenase (NAD(P))
	Aldehyde dehydrogenaseNAD(P) (ALDH) 催化醛氧化成相应的羧酸，伴随辅因子 NAD(P) 还原成 NAD(P)H，常用于生化研究。Aldehyde dehydrogenaseNAD(P) 是人体用来缓解乙醛应激的许多酶系统之一。
T35543	Methyl Diethyldithiocarbamate
	Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and...

化合物

Cat.No: T39675

Synonym: ALDH1A2-IN-1

ALDH2 modulator 1

Cat.No: T67832

Target: Dehydrogenase

4-Diethylaminobenzaldehyde

Cat.No: T10140

Target: Dehydrogenase

Cat.No: T12196

Target: Dehydrogenase

Cat.No: T64347

Target: Dehydrogenase

Cat.No: T6903

Synonym: NCT501

Target: Dehydrogenase

Cat.No: T2662

Synonym: Alda 1

Target: Apoptosis, Dehydrogenase

Cat.No: T63341

Target: Dehydrogenase

Cat.No: T60372

Cat.No: T60240

Target: Dehydrogenase

Cat.No: T23533

Target: Dehydrogenase

Cat.No: T7835

Synonym: CM 10

Target: Dehydrogenase

Cat.No: T0054

Synonym: 双硫伦,Tetraethylthiuram disulfide,双硫仑,NSC 190940,TETD

Target: Dehydrogenase, Interleukin, Pyroptosis

Dyclonine hydrochloride

Cat.No: T1389

Synonym: 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl

Target: Sodium Channel, Antibacterial, Antifungal

Cat.No: T15022

Synonym: 3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸

Target: Dehydrogenase

Cat.No: T60275

Cat.No: T64228

Cat.No: T60550

Cyclosomatostatin Acetate

Cat.No: T21567L

Synonym: Cyclosomatostatin Acetate （84211-54-1 Free base）

Target: Somatostatin

Cat.No: T63081

Cat.No: T63992

Cat.No: T69366

Cat.No: T60363

BODIPY-aminoacetaldehyde diethyl acetal

Cat.No: T35568

BODIPY aminoacetaldehyde

Cat.No: T37869

Cat.No: T37533

Cyclosomatostatin TFA

Cat.No: T75842

NCT-501 hydrochloride

Cat.No: T39485

Aldehyde dehydrogenase (NAD(P))

Cat.No: T76159

Methyl Diethyldithiocarbamate

Cat.No: T35543

Cat. No.	Product Name	Target	Signaling Pathways
TJS1382	Taraxerone 蒲公英赛酮	Dehydrogenase	Metabolism
	Taraxerone 是分离自景天的天然产物。它可以增强乙醇脱氢酶和乙醛脱氢酶活性，EC50分别为 512.42 μM 和 500.16 μM。
T4778	3-Hydroxybenzaldehyde	Others; Dehydrogenase	Metabolism; Others
	3-Hydroxybenzaldehyde 是很多酚类化合物的前体分子。它是人和大鼠醛脱氢酶 (ALDH) 的底物 (substrate)。它具有血管保护的作用。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T10148	4-Hydroxynonenal 4-羟基壬烯醛,4-HNE	Dehydrogenase; Endogenous Metabolite	Metabolism
	4-Hydroxynonenal (4-HNE) 是一种 α，β 不饱和羟基烯醛，可作为氧化/亚硝化应激生物标志物。它是ALDH2的底物和抑制剂。它可以调节许多信号传导过程，主要是通过与蛋白质，核酸和膜脂质中具有亲核官能团的共价加合物形成的。它通过线粒体在癌症中起重要作用。
T2S1181	Aloenin Aloenin A,Aloearbonaside,芦荟宁	Beta-Secretase; AChR	Neuroscience
	Aloenin (Aloenin A) A 是一种具有清除过氧自由基作用的天然产物，对 β-分泌酶 (BACE) 具有中等抑制活性。

天然产物

Cat.No: TJS1382

Synonym: 蒲公英赛酮

Target: Dehydrogenase

3-Hydroxybenzaldehyde

Cat.No: T4778

Target: Others, Dehydrogenase

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

4-Hydroxynonenal

Cat.No: T10148

Synonym: 4-羟基壬烯醛,4-HNE

Target: Dehydrogenase, Endogenous Metabolite

Cat.No: T2S1181

Synonym: Aloenin A,Aloearbonaside,芦荟宁

Target: Beta-Secretase, AChR

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