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Cat. No. | Product Name | Target | Signaling Pathways |
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T10151 |
5-Lipoxygenase-In-1
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Lipoxygenase | Metabolism |
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor. | |||
T61211 |
5-LOX-IN-1
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Lipoxygenase | Metabolism |
5-LOX-IN-1 是一种 5-Lipoxygenase(5-LOX)抑制剂(IC50: 2.3 μM)。5-LOX-IN-1 可用于研究癌症。 | |||
T10098 |
PGS-IN-1
KME-4 |
Lipoxygenase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
PGS-IN-1 (KME-4)是一种前列腺素合成酶抑制剂,IC50=0.28 μM。它也可抑制5-脂肪氧合酶的活性,IC50=1.05 μM。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T75122 | 5-Lipoxygenase-IN-3 | ||
5-Lipoxygenase-IN-3 (Compound 14) 是一种5-Lipoxygenase 抑制剂 (IC50: <1 μM)。5-Lipoxygenase-IN-3 可用于炎症性疾病、癌症、中风和阿尔茨海默病的研究。 | |||
T13263 |
COX/5-LO-IN-1
Atreleuton analog |
COX | Immunology/Inflammation; Neuroscience |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T78820 |
5-LOX-IN-5
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Lipoxygenase | Metabolism |
5-LOX-IN-5(Compound 29)作为一种5-LOX抑制剂,拥有56 nM的半抑制浓度(IC50)。它主要被应用于神经退行性疾病的研究领域。 | |||
T21962 |
HZ52
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HZ52 是一种有效可逆的5-脂氧合酶(5-LO)抑制剂,在完整的人类多形核白细胞中可阻断白三烯的合成,IC50为 0.7 μM。 | |||
T36169 |
15-LOX-1 inhibitor 1
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9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM. | |||
T21821 |
REV 5901
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REV 5901 是一种口服有效的白三烯受体 (leukotriene receptor) 竞争性拮抗剂,Ki 值为 0.7 μM。REV 5901 也是一种 5-脂氧合酶 (5-lipoxygenase) 抑制剂。REV 5901 可用于涉及白三烯释放的哮喘研究。 | |||
T38066 |
5(Z),8(Z),14(Z)-Eicosatrienoic Acid
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5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5-LO from RBL-1 cells converts this fatty acid to 5-hydroxy-6,8,14-eicosatrienoic acid and 5-hydroperoxy-6,8,14-eicosatrienoic acid. Due to the lack of a double bond at C-11, this particular fatty acid cannot be used in leukotriene A formation. | |||
T22172 |
YS-121
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YS121 是微粒体前列腺素 E2 合酶-1 (mPGES-1;IC50=3.4 μM) 和 5-脂氧合酶 (5-LOX;IC50=6.5 μM) 的双重抑制剂。在 IL-1β 刺激的 A549 细胞中,YS121以剂量依赖性地方式减少 PGE2 的产生,EC50为 12 μM。 | |||
T72002 | Carbazomycin C | ||
Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts. | |||
T71761 |
Carbazomycin B
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Carbazomycin B is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against a panel of seven fungi and a panel of seven bacteria, as well as P. falciparum and C. albicans. It is also active against a panel of five plant pathogenic fungi. Carbazomycin B is cytotoxic to MCF-7, KB, NCI H187, and Vero cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.5 µM). | |||
T79389 |
LTB4-IN-2
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FLAP | Immunology/Inflammation |
LTB4-IN-2(Compound 6x)是一种选择性的5-脂氧合酶激活蛋白(FLAP)抑制剂,旨在抑制白三烯B4(LTB4)的形成(IC50:1.15 μM),适用于抗炎研究。 | |||
T37273 |
BLX3887
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BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro. |1... | |||
T36457 |
CAY10416
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Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 ... | |||
T78705 |
COX-2-IN-30
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COX | Immunology/Inflammation; Neuroscience |
COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂,其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用,不引发急性胃部反应。 | |||
T35943 |
15(S)-HpETE
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15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by peroxidases.[2] [1] 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. [3] 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inac... | |||
T83773 |
Prostaglandin E2 Inhibitor 3
PGE2 Inhibitor 3 |
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Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂,相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH),在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下,该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中,LPS诱导的IL-6和PGE2生成。同时,它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成,包括白三烯B4 (LTB4) 和5-H(p)ETE(IC50s分别为4.9和5.2 µM)。在体内,10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。 | |||
T37969 |
12(S)-HpETE
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12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and e... | |||
T37393 |
13(S)-HpODE
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13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals.3 In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.4 In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE,a compound which exhibits many biological activities.3 A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimula... | |||
T37971 |
12-oxo-13-HOME
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12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunflower seedlings.4 1.Ogorodnikova, A.V., Gorina, S.S., Mukhtarova, L.S., et al.Stereospecific biosynthesis of (9S,13S)-10-oxo-phytoenoic acid in young maize rootsBiochim. Biophys. Acta1851(9)1262-1270(2015) 2.Veldink, G.A., and Vliegenthart, J.F.G.The enzymic conversions of 13-hydr... | |||
T35881 |
Resolvin E2
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m... | |||
T35946 |
17(R)-Resolvin D1
Aspirin-triggered Resolvin D1,17(R)-Resolvin D1 |
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Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear... | |||
T38043 |
Resolvin E4
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Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism... | |||
T37166 |
RCTR1
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Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T37272 |
9(S),12(S),13(S)-TriHOME
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... |