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Cat. No.	Product Name	Target	Signaling Pathways
T1291	Cisapride 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase	Potassium Channel; 5-HT Receptor; HER	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Cisapride (R 51619) 是一种5-HT4受体激动剂，还是 hERG 抑制剂。它可作用于肠道中的血清素受体，促进肠道蠕动，增加胃排空并减少食管反流。
T21946	BIMU 8	5-HT Receptor	GPCR/G Protein; Neuroscience
	BIMU 8 是 5-HT4 的选择性激动剂，对野生型 5HT4 受体、T3.36A 和 W6.48A 突变体 5-HT4 的 EC50 分别为 18 nM、77 nM 和 540 nM。
T22671	CJ 033466	5-HT Receptor	GPCR/G Protein; Neuroscience
	CJ 033466 是 5-HT4 受体 (EC50 = 9 nM) 的特异性部分激动剂，具有促胃动力作用。
T22992	ML 10302 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	ML 10302 hydrochloride 是一种特异性激动剂 5-HT4 并结合 5-HT 受体，5-HT4 和 5-HT3 的 Kis 分别为 1.07 nM 和 782 nM。
T28934	Felcisetrag TD 8954,TD8954,TD-8954	5-HT Receptor	GPCR/G Protein; Neuroscience
	Felcisetrag (TD-8954) 是一种有效且选择性的口服活性 5-HT4 受体激动剂，具有胃肠道促动力特性。Felcisetrag 对人类重组 5-HT4(c) (h5-HT4(c)) 受体显示出高亲和力，pKi 为9.4。
T28043L	Minesapride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Minesapride 是一种新型5-羟色胺4（5-HT4）受体部分激动剂，是一种潜在的胃肠道促动力剂，可用于治疗肠易激综合征伴便秘。
T6958	Prucalopride Succinate 琥珀酸普芦卡必利,R-108512,琥珀酸普卡比利,Resolor Succinate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Prucalopride Succinate (Resolor Succinate) 是5-HT4受体选择高亲和性激动剂，对5-HT4a 和5-HT4b 的 Ki 值分别为 2.5 和 8 nM。
T27117	DA-6886 DA6886,DA 6886	5-HT Receptor	GPCR/G Protein; Neuroscience
	DA-6886 是一种 5-羟色胺受体 4（5-HT4）激动剂。DA-6886 以 5-HT4 受体拮抗剂敏感的方式诱导大鼠食道制剂松弛。在表达 hERG 通道的 CHO 细胞中对 DA-6886 进行的评估显示，它抑制 hERG 通道电流的 pIC50 值为 4.3，表明该化合物对 5-HT4 受体的选择性比 hERG 通道高 1000 倍。
T38507	Renzapride BRL 24924	5-HT Receptor	GPCR/G Protein; Neuroscience
	Renzapride (BRL 24924) 是一种混合 5-羟色胺 4 型（5-HT4）激动剂和 5-HT3 受体拮抗剂。Renzapride 可用于研究以便秘为主的肠易激综合征（C-IBS）。
T5336	Zacopride hydrochloride	Potassium Channel; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Zacopride hydrochloride 是5-HT3受体拮抗剂 (Ki:0.38 nM)，也是5-HT4受体激动剂 (Ki:373 nM)，具有抗焦虑作用。它对精神分裂症具有潜在的研究价值。
T68035	Capeserod SL-650155,SL-65.0155	5-HT Receptor	GPCR/G Protein; Neuroscience
	Capeserod 是一种潜在的 5-HT4 receptor(5-羟色胺受体4)激动剂，可用于研究消化系统疾病和神经系统疾病。
T68116L	(Rac)-Norcisapride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Norcisapride 是一种5-羟色胺受体3（5-HT3）和(5-羟色胺受体4（5-HT4）双重激动剂，可用于治疗消化系统疾病、口颌疾病和耳鼻咽喉疾病。
T21385	Cinitapride 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动，以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。
T23265	RS 67333 hydrochloride RS 67333 (hydrochloride),RS 67333 HCl,盐酸RS67333	5-HT Receptor	GPCR/G Protein; Neuroscience
	RS 67333 hydrochloride (RO5203648) 是一种有效的、选择性的5-HT4 受体 (5-HT4R) 部分激动剂，在豚鼠纹状体中的 pKi 为 8.7。RS 67333 hydrochloride 对其他几种受体的亲和力较低，包括 5-HT1A、5-HT1D、5-HT2A、5-HT2C、多巴胺 D1、D2 和毒蕈碱 M1-M3 受体。RS 67333 hydrochloride 具有神经保护作用，可用于阿尔茨海默病研究。
T1551	Tegaserod maleate HTF-919,马来酸替加色罗,SDZ-HTF-919	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tegaserod maleate (SDZ-HTF-919) 是选择性5-HT4受体的部分激动剂和5-HT2B 受体的拮抗剂，用于治疗肠易激综合征和便秘。
T4616	Metoclopramide 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T2542L	Prucalopride hydrochloride Prucalopride HCl
	Prucalopride hydrochloride is a selective agonist of the 5-HT4.
T71308	DSP-6952
	DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction.
T22294	Cinitapride Hydrogen Tartrate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors
T28696	SC 53116 Hydrochloride SC 53116,SC53116,SC-53116,SC 53116 HCl
	SC 53116 Hydrochloride is selective agonist of the newly identified serotonin 5-HT4 receptor subtype.
T22296	Cisapride hydrate Propulsid,Alimix,Enteropride,Kinestase,西沙比利,Propulsin	EGFR; 5-HT Receptor	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
T23791	BIMU-1
	BIMU-1 is an agonist of 5-HT4 receptor.
T26944	Capeserod HCl SL-65.0155,SL-650155,SL 650155,SL 65.0155
	Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.
T29115	VRX 03011 Potassium salt PRX-03140,PRX3140,NTC942,NTC-942,PRX-3140,PRX03140
	VRX 03011, a 5-HT4 partial agonist, is used potentially for the treatment of Alzheimer's disease.
T27021	Cinitapride Tartrate
	Cinitapride Tartrate is an agonist of the 5-HT1 and 5-HT4 receptors and is also an antagonist of the 5-HT2 receptors.
T6597L	Mosapride citrate dihydrate GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370
	Mosapride Citrate is a 5-HT4 receptor agonist used to stimulate gastrointestinal motility via acetylcholine. Mosapride Citrate facilitates acetylcholine release from the enteric cholinergic neurons.
T28517	Renzapride hydrochloride BRL-24924,ATL1251,ATL-1251,Renzapride HCl,AZM-112
	Renzapride is a 5-HT3 antagonist and 5-HT4 agonist. Renzapride also functions as a 5-HT2B antagonist and has some affinity for the 5-HT2A and 5-HT2C receptors.
T34751	Usmarapride free base SUVN-D4010,SUVN-D 4010,SUVN-D-1208045,SUVN-1004028,SUVN D4010,SUVN-D1003019
	SUVN-D4010 is an effective, selective, brain penetrant, and orally active agonist of 5-HT4 receptor partially used to treat Alzheimer's disease and other dementia-related cognitive dysfunction.
T16737	Revexepride	Others	Others
	Revexepride is a highly selective agonist of the 5-HT4 receptor and a potential inducer of CYP3A4 enzyme. Revexepride is used for the treatment of gastroesophageal reflux disease.
T35046	Velusetrag TD 5108,TD5108,TD-5108
	Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome.
T68116	norcisapride
	Norcisapride 属于被称为二苯基吡咯的一类有机化合物。Norcisapride 直接作为5-羟色胺5-HT4受体激动剂发挥作用，并间接作为拟副交感神经发挥作用。Norcisapride 是 Cisapride 的代谢产物。
T72809	(S)-Renzapride (S)-BRL 24924
	(S)-Renzapride ((S)-BRL 24924) 是 Renzapride 的异构体。Renzapride 是一种 5-HT4受体激动剂，Ki 值为 115 nM。Renzapride 还是一种5HT2b 和5HT3受体拮抗剂。Renzapride 可用于便秘型肠易激综合征（C-IBS）的研究。
T63069	Usmarapride
	Usmarapride (SUVN-D4010) 是一种选择性的、口服具有活力的、有效的、具有血脑屏障通透性的 5-HT4 受体部分激动剂，其 EC50 值为 44 nM。Usmarapride (SUVN-D4010) 能够用于研究阿尔茨海默病相关认知缺陷。
T60787	ML 10302
	ML 10302 是5-HT4受体的有效激动剂(Ki = 1.07 nM)，通过激活胆碱能通路在小肠和结肠中诱导明显的运动促进，并具有神经疾病的研究潜力。
T70070	Cisapride tartrate
	Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o...

化合物

Cat.No: T1291

Synonym: 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase

Target: Potassium Channel, 5-HT Receptor, HER

Cat.No: T21946

Target: 5-HT Receptor

Cat.No: T22671

Target: 5-HT Receptor

ML 10302 hydrochloride

Cat.No: T22992

Target: 5-HT Receptor

Cat.No: T28934

Synonym: TD 8954,TD8954,TD-8954

Target: 5-HT Receptor

Cat.No: T28043L

Target: 5-HT Receptor

Prucalopride Succinate

Cat.No: T6958

Synonym: 琥珀酸普芦卡必利,R-108512,琥珀酸普卡比利,Resolor Succinate

Target: 5-HT Receptor

Cat.No: T27117

Synonym: DA6886,DA 6886

Target: 5-HT Receptor

Cat.No: T38507

Synonym: BRL 24924

Target: 5-HT Receptor

Zacopride hydrochloride

Cat.No: T5336

Target: Potassium Channel, 5-HT Receptor

Cat.No: T68035

Synonym: SL-650155,SL-65.0155

Target: 5-HT Receptor

(Rac)-Norcisapride

Cat.No: T68116L

Target: 5-HT Receptor

Cat.No: T21385

Synonym: 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove

Target: 5-HT Receptor

RS 67333 hydrochloride

Cat.No: T23265

Synonym: RS 67333 (hydrochloride),RS 67333 HCl,盐酸RS67333

Target: 5-HT Receptor

Tegaserod maleate

Cat.No: T1551

Synonym: HTF-919,马来酸替加色罗,SDZ-HTF-919

Target: 5-HT Receptor

Cat.No: T4616

Synonym: 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide

Target: Dopamine Receptor, 5-HT Receptor

Prucalopride hydrochloride

Cat.No: T2542L

Synonym: Prucalopride HCl

Cat.No: T71308

Cinitapride Hydrogen Tartrate

Cat.No: T22294

Target: 5-HT Receptor

SC 53116 Hydrochloride

Cat.No: T28696

Synonym: SC 53116,SC53116,SC-53116,SC 53116 HCl

Cisapride hydrate

Cat.No: T22296

Synonym: Propulsid,Alimix,Enteropride,Kinestase,西沙比利,Propulsin

Target: EGFR, 5-HT Receptor

Cat.No: T23791

Cat.No: T26944

Synonym: SL-65.0155,SL-650155,SL 650155,SL 65.0155

VRX 03011 Potassium salt

Cat.No: T29115

Synonym: PRX-03140,PRX3140,NTC942,NTC-942,PRX-3140,PRX03140

Cinitapride Tartrate

Cat.No: T27021

Mosapride citrate dihydrate

Cat.No: T6597L

Synonym: GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370

Renzapride hydrochloride

Cat.No: T28517

Synonym: BRL-24924,ATL1251,ATL-1251,Renzapride HCl,AZM-112

Usmarapride free base

Cat.No: T34751

Synonym: SUVN-D4010,SUVN-D 4010,SUVN-D-1208045,SUVN-1004028,SUVN D4010,SUVN-D1003019

Cat.No: T16737

Target: Others

Cat.No: T35046

Synonym: TD 5108,TD5108,TD-5108

Cat.No: T68116

Cat.No: T72809

Synonym: (S)-BRL 24924

Cat.No: T63069

Cat.No: T60787

Cisapride tartrate

Cat.No: T70070

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