Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DA-6886 是一种 5-羟色胺受体 4(5-HT4)激动剂。DA-6886 以 5-HT4 受体拮抗剂敏感的方式诱导大鼠食道制剂松弛。在表达 hERG 通道的 CHO 细胞中对 DA-6886 进行的评估显示,它抑制 hERG 通道电流的 pIC50 值为 4.3,表明该化合物对 5-HT4 受体的选择性比 hERG 通道高 1000 倍。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 980 | 现货 | ||
5 mg | ¥ 2,360 | 现货 | ||
10 mg | ¥ 3,530 | 现货 | ||
25 mg | ¥ 5,730 | 现货 | ||
50 mg | ¥ 7,990 | 现货 | ||
100 mg | ¥ 10,700 | 现货 | ||
500 mg | ¥ 21,500 | 现货 |
产品描述 | DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels. |
体内活性 | In the normal ICR mice, DA-6886 (0.4 and 2mg/kg; oral) resulted in a marked stimulation of colonic transit. In the loperamide-induced constipation mouse model, DA-6886 (2mg/kg) significantly improved the delay of colonic transit. Taken together, DA-6886 is a highly potent and selective 5-HT4 receptor agonist to accelerate colonic transit in mice, which might be a therapeutic agent having a favorable safety profile in the treatment of gastrointestinal motor disorders such as IBS-C and chronic constipation.[1] |
别名 | DA6886, DA 6886 |
分子量 | 443.37 |
分子式 | C19H28Cl2N6O2 |
CAS No. | 1645260-76-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (101.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2555 mL | 11.2773 mL | 22.5545 mL | 56.3863 mL |
5 mM | 0.4511 mL | 2.2555 mL | 4.5109 mL | 11.2773 mL | |
10 mM | 0.2255 mL | 1.1277 mL | 2.2555 mL | 5.6386 mL | |
20 mM | 0.1128 mL | 0.5639 mL | 1.1277 mL | 2.8193 mL | |
50 mM | 0.0451 mL | 0.2255 mL | 0.4511 mL | 1.1277 mL | |
100 mM | 0.0226 mL | 0.1128 mL | 0.2255 mL | 0.5639 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DA-6886 1645260-76-9 GPCR/G Protein Neuroscience 5-HT Receptor DA6886 DA 6886 Inhibitor inhibitor inhibit