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Search Results for " α-synuclein "

38

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40541	α-Synuclein (61-75)
	α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disease (PD).
T9722	YTX-465	Stearoyl-CoA Desaturase (SCD)	Metabolism
	YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂，抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。
T80151	α-Synuclein 4554W
	α-Synuclein4554W是一种α-Synuclein(aSyn)聚集抑制剂，对应毒性相关。它含GIVNGVKA序列，该序列通过细胞内文库筛选鉴定而来。α-Synuclein4554W能够减少与帕金森病相关的aSyn突变体的原纤维形成。
T61644	α-Synuclein inhibitor 6
	α-Synuclein inhibitor 6 (compound 3ge) is a highly effective and blood-brain barrier-permeable inhibitor that targets the aggregation of α-Synuclein (α-Syn). It exhibits a potent inhibitory activity, with an IC50 value of 1.70 μM, leading to a remarkable inhibition ratio of 94.4% at 30 μM [1].
T78842	α-Synuclein inhibitor 9
	α-Synuclein inhibitor9 (Compound 20C) 是一种针对 α-Synuclein 的抑制剂，通过与成熟 α-Synuclein 原纤维内的空腔结合，减少了 β-折叠构型，并有效阻止 A53T α-Syn 的聚集。由于其神经保护性质，该化合物能够改善大脑功能性连接并缓解运动障碍，适用于帕金森病 (PD) 的相关研究。
T61920	α-Synuclein inhibitor 7
	α-Synuclein inhibitor 7 (化合物 3gf) 是有效的α-Synuclein (α-Syn)聚集的抑制剂，IC50为 1.95 μM，30 μM 处的抑制率为 85.8%。α-Synuclein inhibitor 7具有血脑屏障通透性。
T61611	α-Synuclein inhibitor 4
	α-Synuclein inhibitor 4 (compound 3gh) is a highly effective and blood-brain barrier-permeable inhibitor of α-Synuclein aggregation. It displays potent activity, with an IC50 value of 0.98 μM, and exhibits a remarkable inhibition ratio of 91.2% at a concentration of 30 μM [1].
T62131	α-Synuclein inhibitor 5
	α-Synuclein inhibitor 5 是一种有效的、能够透过血脑屏障的 α-Synuclein (α-Syn) 聚集的抑制剂 (IC50: 1.22 μM)，在 30 μM 时的抑制率为 94.3%。
T61404	α-Synuclein inhibitor 3
	α-Synuclein inhibitor 3 (Compound 7g) is a potent inhibitor of α-synuclein (α -Syn) aggregation. It has potential applications in Parkinson's disease research [1].
T72314	α-Synuclein inhibitor 8
	α-Synuclein inhibitor8 是一种高效的抑制剂，对α-Synuclein纤维的聚集及解聚作用有高度抑制效果，IC50值为2.5 µM。它能显著减少神经元细胞内的内含物形成，并有助于修复受损神经元，改善PD样症状。此外，该化合物具有较强的抗氧化性能和低细胞毒性。
T78629	PROTAC α-synuclein degrader 3	PROTACs	PROTAC
	PROTACα-synuclein degrader 3 (compound 5) 为高效的选择性 PROTACα-synuclein 降解剂，适用于帕金森病研究。
T62096	Dyrk1A/α-synuclein-IN-1
	Dyrk1A/α-synuclein-IN-1 (Compound b1) 是一种双重的 Dyrk1A (IC50: 177 nM) 和 α-synuclein aggregation (IC50: 10.5 μM) 抑制剂。Dyrk1A/α-synuclein-IN-1 表现出较好的预测 CNS 渗透性和神经保护活性。
T79250	PROTAC α-synuclein degrader 5	PROTACs	PROTAC
	PROTACα-synuclein degrader 5为针对α-synuclein聚集体的高度选择性小分子(PROTAC)，具有DC50值为7.51 μM和最大降解率Dmax达89%。该化合物结合了探针分子sery308与E3 ligase链接剂，适用于神经系统疾病研究。
T62226	Dyrk1A/α-synuclein-IN-2
	Dyrk1A/α-synuclein-IN-2 (Compound b20) 是一种双重的 Dyrk1A 和α-synuclein aggregation 的抑制剂，能够作用于α-synuclein (IC50: 7.8 μM)。Dyrk1A/α-synuclein-IN-2 具有较高的预测 CNS 渗透性和神经保护作用。
T76199	α-Synuclein (61-75) (TFA)
	α-Synuclein(61-75) TFA 是α-Synuclein 的 61-75 片段。α-Synuclein 是一种丰富的神经元蛋白，在突触前神经末梢高度丰富。α-Synuclein 是一种帕金森氏病 (PD) 的生物标志物。
T80118	α-Synuclein (61-95) (human)
	α-Synuclein(61-95) (human) 是 α-Synuclein 的疏水核心区段，具有诱导神经元死亡的能力。该肽段在神经退行性疾病的研究中有应用，涉及阿尔茨海默病 (AD) 与帕金森病 (PD)。
T81031	tau protein/α-synuclein-IN-1
	tau protein/α-synuclein-IN-1为tau protein与α-synuclein双重抑制剂，能够抑制M17D神经母细胞瘤细胞中α-syn包涵体的形成，适用于阿尔茨海默病相关研究。
T4659	ELN484228	Others	Others
	ELN484228 是一种 α-突触核蛋白的阻断剂。α-突触核蛋白是帕金森病中的关键蛋白质。
T62304	Minzasolmin (R)-NPT200-11,UCB0599,DLX-313	Others	Others
	Minzasolmin（DLX-313）是一种 α-突触核蛋白错误折叠抑制剂，可用于研究帕金森疾病。
T13048	SynuClean-D SC-D	Others	Others
	SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
T76861	Cinpanemab BIIB054	Others	Others
	Cinpanemab (BIIB054) 是一种新型人源单克隆抗体，对 α-突触核蛋白 1-10 位残基具有亲和力。Cinpanemab 可用于研究帕金森及其相关疾病。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T83726	Tat-βsyn-degron TFA
	Tat-βsyn-degron是一种降低α-synuclein表达的肽。其结构包括HIV-1 Tat质膜跨导域、与β-synuclein氨基酸36-45相对应的α-synuclein结合域βsyn，以及蛋白酶体定向域degron。在肽-蛋白结合实验中，Tat-βsyn-degron能够与重组α-synuclein结合，并在大鼠初级皮质神经元培养中降低α-synuclein水平，这一效应可以通过蛋白酶体抑制剂MG132阻止。体内研究显示，Tat-βsyn-degron (40 mg/kg)能够在过表达人类A53T突变体α-synuclein的M38转基因小鼠的大脑中降低α-synuclein水平，并且在黑质和脑桥中降低磷酸化α-synuclein水平，以及在通过α-synuclein预成纤维诱导的扩散性α-synuclein病理模型小鼠中减少神经炎症。此外，Tat-βsyn-degron (6 µmol/kg, i.p.)在MPTP诱导的帕金森病小鼠模型中，保护多巴胺能神经元，缓解运动缺陷。
T13049	Synucleozid NSC 377363	Others	Others
	Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.
T76889	Prasinezumab
	Prasinezumab (PRX 002) 为针对聚集α-突触核蛋白 (α-synuclein) 的人源化IgG1单克隆抗体，展现在帕金森病研究中的应用潜力。
T68763	PQQ-TME
	PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.
T71174	PBT434 HBr
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g...
T74974	SQ-3
	SQ-3为一种喹啉类似物，对α-syn聚合体（Ki=39.3 nM）显示中等选择性，其选择性高于对β-淀粉样蛋白（Aβ）聚合体（Ki=230 nM）。[18F]SQ3展现出作为α-syn成像探针的先导化合物的基本属性。
T72280	PBT434 methanesulfonate
	PBT434 methanesulfonate 为一种有效、口服活性并能穿透血脑屏障的α-synuclein aggregation抑制剂，同时担任铁螯合剂和跨细胞铁运输的调节剂。该化合物抑制铁介导的氧化还原活性及α-synuclein聚集，可有效防止SNpc神经元丢失，显示出在PD研究中的应用潜力。
T13049L	Synucleozid hydrochloride (502139-01-7 free base) Synucleozid hydrochloride,NSC 377363 hydrochloride	Others	Others
	Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.
T83875	HUP-55
	HUP-55是一种脯氨酸内肽酶的抑制剂（IC50 = 5 nM）。在10 µM的浓度下，它可减少Neuro2a细胞中α-突触核蛋白二聚体的形成，促使HEK293细胞发生自噬，并降低SH-SY5Y细胞中由过氧化氢诱导的反应性氧种（ROS）产量的增加。此外，HUP-55（10 mg/kg）在通过腺病毒递送α-突触核蛋白编码载体（AAV-αSyn）诱导的帕金森病小鼠模型中，能减少患侧爪的使用和纹状体中寡聚体α-突触核蛋白水平。
T74770	D-685
	D-685作为D-520的前体药物，在帕金森病(PD)血脂化动物模型中展示了优于D-520的体内抗PD功效。此外，D-685能降低人类α-突触核蛋白(α-syn)的累积，且具有更高的大脑透过性。
T78171	QR-0217
	QR-0217是一种有效的Aβ1-40聚集抑制剂，具有7.5 µM的IC50值，阻断α-突触核蛋白的聚集，并可减轻Aβ神经毒性导致的记忆障碍。
T70941	CLR01 sodium
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
T83328	4A7C-301
	4A7C-301是一种Nurr1激动剂，体外显示出强大的神经保护能力。在AAV2介导的α-突触核蛋白过表达雄鼠模型中，该化合物能显著纠正神经病理学异常，并改善运动及嗅觉功能障碍。此外，4A7C-301适用于帕金森病相关研究。
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as wel...
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...
T83894	4A7C-301-Nurr1 Agonist 4A7C-301-Nuclear Receptor-Related 1
	4A7C-301-Nurr1激动剂是一种核受体相关1（Nurr1）的激动剂。它通过与Nurr1配体结合域（LBD；IC50 = 48.22 nM）结合，增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性（EC50s = 6.53 和 50-70 µM，分别）。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡，并减少运动和嗅觉缺陷，而不诱发类似运动障碍的行为。

化合物

α-Synuclein (61-75)

Cat.No: T40541

Cat.No: T9722

Target: Stearoyl-CoA Desaturase (SCD)

α-Synuclein 4554W

Cat.No: T80151

α-Synuclein inhibitor 6

Cat.No: T61644

α-Synuclein inhibitor 9

Cat.No: T78842

α-Synuclein inhibitor 7

Cat.No: T61920

α-Synuclein inhibitor 4

Cat.No: T61611

α-Synuclein inhibitor 5

Cat.No: T62131

α-Synuclein inhibitor 3

Cat.No: T61404

α-Synuclein inhibitor 8

Cat.No: T72314

PROTAC α-synuclein degrader 3

Cat.No: T78629

Target: PROTACs

Dyrk1A/α-synuclein-IN-1

Cat.No: T62096

PROTAC α-synuclein degrader 5

Cat.No: T79250

Target: PROTACs

Dyrk1A/α-synuclein-IN-2

Cat.No: T62226

α-Synuclein (61-75) (TFA)

Cat.No: T76199

α-Synuclein (61-95) (human)

Cat.No: T80118

tau protein/α-synuclein-IN-1

Cat.No: T81031

Cat.No: T4659

Target: Others

Cat.No: T62304

Synonym: (R)-NPT200-11,UCB0599,DLX-313

Target: Others

Cat.No: T13048

Synonym: SC-D

Target: Others

Cat.No: T76861

Synonym: BIIB054

Target: Others

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Tat-βsyn-degron TFA

Cat.No: T83726

Cat.No: T13049

Synonym: NSC 377363

Target: Others

Cat.No: T76889

Cat.No: T68763

Cat.No: T71174

Cat.No: T74974

PBT434 methanesulfonate

Cat.No: T72280

Synucleozid hydrochloride (502139-01-7 free base)

Cat.No: T13049L

Synonym: Synucleozid hydrochloride,NSC 377363 hydrochloride

Target: Others

Cat.No: T83875

Cat.No: T74770

Cat.No: T78171

Cat.No: T70941

Cat.No: T83328

Cat.No: T37533

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

4A7C-301-Nurr1 Agonist

Cat.No: T83894

Synonym: 4A7C-301-Nuclear Receptor-Related 1

Cat. No.	Product Name	Target	Signaling Pathways
TN1140	Onjisaponin B	AMPK; mTOR; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Onjisaponin B 是从远志中提取的一种天然产物，可通过 AMPK-mTOR 信号通路诱导自噬，提高 NGF 水平并加速突变型亨廷顿蛋白和 A53T α±-突触核蛋白的清除，可研究帕金森病和亨廷顿病。
T7441	Cuminaldehyde Cuminic aldehyde,4-异丙基苯甲醛,Cuminal	Endogenous Metabolite	Metabolism
	Cuminaldehyde (Cuminal) 是一种具有抑制 α-突触核蛋白纤颤和细胞毒性作用的天然醛，是一种 Cuminum cyminum 的主要成分。它显示抗癌特性。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
T72962	Sycosterol A
	Sycosterol A 是一种α-synuclein(α-syn)甾醇抑制剂。
TN2149	Reynosin	BCL; Others; TNF	Apoptosis; Others
	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α±-synuclein protein expr
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。

天然产物

Cat.No: TN1140

Target: AMPK, mTOR, Autophagy

Cat.No: T7441

Synonym: Cuminic aldehyde,4-异丙基苯甲醛,Cuminal

Target: Endogenous Metabolite

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

Cat.No: T72962

Cat.No: TN2149

Target: BCL, Others, TNF

Corynoxine hydrochloride

Cat.No: T75438

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