Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74765 | Viral polymerase-IN-1 hydrochloride | ||
Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物,有效抑制甲型和乙型流感病毒 (influenza) 感染,IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。 | |||
T0220 |
Foscarnet sodium
Phosphonoformate,膦甲酸钠 |
Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂,可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。 | |||
T27154 |
Dexelvucitabine
D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC |
Reverse Transcriptase | Microbiology/Virology |
Dexelvucitabine (RVT) 是一种胞苷类似物,一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂,这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。 | |||
T1643 |
Penciclovir
喷昔洛韦,BRL 39123,VSA 671 |
HCV Protease; Antifection; HSV | Microbiology/Virology; Proteases/Proteasome |
Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2,IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。 | |||
T69941 |
CMX-521
|
||
CMX521 is an antiviral drug candidate, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotovirus and some sapoviruses, astroviruses and adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase. | |||
T1533 |
Valganciclovir hydrochloride
Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte |
Others; Antiviral | Immunology/Inflammation; Others |
Valganciclovir hydrochloride (Valganciclovir HCl) 是 ganciclovir 的原药,具有抗巨细胞病毒活性,可抑制病毒 DNA 聚合酶和病毒复制。 | |||
T10491 |
Galidesivir
BCX4430,Immucillin-A |
Others | Others |
Galidesivir (BCX4430) 是一种广谱抗病毒化合物,是一种腺苷类似物,能抑制病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 活性。Galidesivir 在体外对多种 RNA 病毒病原体有抑制作用,可减少受感染动物的肺部感染。 | |||
T3489 |
Dasabuvir
ABT-333,达塞布韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂,是一种 RNA 依赖性 RNA 聚合酶,具有抗 HCV 的潜在活性。 | |||
T8736 |
Cidofovir dihydrate
HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物 |
Others | Others |
Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂,通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制,从而阻止病毒复制和转录。 | |||
T8886 |
NITD-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂,可抑制 DENV RdRp 介导的 RNA 延伸。 | |||
T67801 |
GS-6620 PM
|
||
GS-6620 PM 是GS-6620的衍生物。GS-6620是一种口服的抗丙型肝炎病毒聚合酶抑制剂,是一种新型强效的C-核苷腺嘌呤类似物单磷酸酯原药。GS-6620对其他病毒的活性有限,对密切相关的牛病毒性腹泻病毒仅保持部分活性(EC50,1.5μM)。 | |||
T6446 |
Clevudine
L-FMAU,克拉夫定,Levovir |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。 | |||
T19476 |
NHC-triphosphate
|
Others | Others |
NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels. | |||
T41002 |
HCVP-IN-1
|
||
HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor. | |||
T12526 |
PP7
|
Influenza Virus | Microbiology/Virology |
PP7 是一种PB1-PB2互作抑制剂,IC50为 8.6 μM。PB1-PB2 抑制病毒聚合酶的活性,IC50为9.5 μM。它对甲型流感病毒 A 包括 (H1N1)pdm09 (EC50=1.4 μM),A(H7N9),A(H9N2) 亚型具有抗病毒活性。 | |||
T11352 |
Galidesivir triphosphate
BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870 |
Others | Others |
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir. | |||
T10491L |
Galidesivir hydrochloride
BCX 4430 hydrochloride,Immucillin-A hydrochloride |
Others | Others |
Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp. | |||
T69345 |
Fosfonet sodium
|
||
Fosfonet sodium is a sodium salt formulation of phosphonoacetic acid with activity against herpes simplex viruses and other members of the herpes virus family. Fosfonet inhibits viral DNA polymerase and inhibits the synthesis of viral DNA. | |||
T19632 |
Lobucavir
BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514 |
||
Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis. | |||
T73983 |
Cidofovir diphosphate tri(triethylamine)
|
||
Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂,对 HCMV,HSV-1和 HSV-2的 Ki 值分别为 6.6,0.86 和 1.4 μM。 | |||
T32050 |
HCV-371
HCV 371 |
||
HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerase | |||
T61492 |
Idoxuridine hydrate
|
||
Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1]. | |||
T70855 | Favipiravir sodium | ||
Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses. | |||
T41177 |
Galidesivir dihydrochloride
BCX 4430 |
||
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models. | |||
T4377L |
Pimodivir HCl
Pimodivir hydrochloride hemihydrate,Pimodivir hydrochloride |
||
Pimodivir is an inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. The cell-based EC50 for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay. VX-787 is active against a diverse | |||
T74070 | NHC-triphosphate tetrasodium | ||
NHC-triphosphate tetrasodium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite),以三磷酸盐的形式存在。NHC-triphosphate tetrasodium 是病毒聚合酶 (viral polymerase) 的弱底物替代物,会被并入HCV 复制子 RNA 中。 | |||
T74652 |
2'-Deoxy-2'-fluoro-l-uridine
|
||
2'-Deoxy-2'-fluoro-l-uridine,一种L-核苷类化合物,作为有效的选择性病毒RNA聚合酶抑制剂,通过抑制RNA病毒的复制发挥作用。 | |||
T60709 |
Acyclovir monophosphate
|
||
Acyclovir monophosphate 是抗单纯疱疹病毒 (HSV)剂,并且具有抗肿瘤活性。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶从而阻断 DNA 合成,同时能终止病毒 DNA 的链延伸。 | |||
T25106 |
Aranotin
L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL |
||
Aranotin 是一种从金黄色蜘蛛中分离的真菌毒素,具有对抗脊髓灰质炎病毒、柯萨奇病毒、犀牛和副流感病毒等 RNA 病毒的活性。Aranotin 通过阻碍 RNA 依赖性RNA 聚合酶的活性来抑制病毒RNA 的合成。 | |||
T36881 |
NHC-diphosphate triammonium
|
||
NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono... | |||
T80655 |
BVDU 5′-Triphosphate
BVdUTP,(E)-5-(2-Bromovinyl)-dUTP |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒(VZV)和单纯疱疹病毒 1 型(HSV-1)具有高度选择性,这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。 | |||
T70207 |
Pimodivir tosylate
|
||
Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay... | |||
T80729 |
ZIKV-IN-6
|
||
ZIKV-IN-6(化合物22)是一种针对寨卡病毒(ZIKV)的抑制剂,显示出低细胞毒性(CC50>50 μM)。该化合物能够直接结合至ZIKV RdRp,进而抑制ZIKV NS5的病毒RNA合成功能,并能够抑制过度炎症反应以及细胞的焦亡(pyroptosis)。 | |||
T79221 |
RSV L-protein-IN-5
|
RSV | Microbiology/Virology |
RSVL-protein-IN-5(compound E)是一种高效针对呼吸道合胞病毒(RSV)的抑制剂,拥有EC50值为0.1 μM。该化合物在IC50为0.66 μM的条件下能够抑制聚合酶(Polymerase),并通过阻断病毒转录物的鸟苷酸化过程来抑止RSVmRNA的合成。RSVL-protein-IN-5具有中等细胞毒性(CC50为10.7 μM,HEp-2细胞),同时,在每日4.1 mg/kg剂量下,能减少RSV感染小鼠模型中的病毒滴度。 | |||
T69657 |
GS-441524 HCl
|
||
GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations ... | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |