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Cat. No. | Product Name | Target | Signaling Pathways |
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T40417 |
Ethylhydrocupreine hydrochloride
Optochin hydrochloride,乙氢去甲奎宁盐酸盐;奥普托欣盐酸盐 |
Antibacterial; Parasite | Microbiology/Virology |
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物,具有抗菌作用,可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性,对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1,ggTas2r2和ggTas2r7) 激动剂。 | |||
T1499 |
Dutasteride
GG 745,Avodart,度他雄胺,GI 198745 |
Apoptosis; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Dutasteride (GI 198745) 是一种 5α 还原酶同工酶抑制剂,还可能因其结构域 DHT 相似对雄激素受体产生脱靶效应。 | |||
T11040 |
Dihydro Dutasteride
|
Others | Others |
Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is an effective inhibitor of five α-reductase isozymes. | |||
T10179 |
5β-Dutasteride
|
Others | Others |
5β-Dutasteride is the S configuration of Dutasteride. It is a potent inhibitor of both 5 alpha-reductase isozymes. | |||
T34373 |
RO5166017
RO 5166017,RO-5166017 |
Others | Others |
RO5166017 是一种具有口服活性、高效性和选择性的痕量胺相关受体 1(TAAR1)激动剂,可用于研究条件性味觉厌恶额神经障碍。 | |||
T28258L |
Org 13011
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Org 13011 具有中枢神经系统活性,通过介导 5-HT 1A受体可诱导条件性味觉厌恶。 | |||
T9367 |
3-(Trifluoromethyl)benzaldehyde
3-三氟甲基苯甲醛,3-Trifluoromethylbenzaldehyde |
Others | Others |
3-(Trifluoromethyl)benzaldehyde (3-Trifluoromethylbenzaldehyde) 有强烈的甜味,被用作调味剂,香水和化妆品的生产,以及作为中间体合成各种化合物。 | |||
TP2500 |
Cholecystokinin (26-33) free acid
CCK (26-33) free acid |
cholecystokinin | GPCR/G Protein |
Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分, 是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体,可诱导大鼠轻度味觉厌恶条件反射。 | |||
T22352 |
L-Gulose
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Gulose 是一种合成维生素 C 的生物中间体,是一种 L-sorbosone 的呋喃糖形式,是L 己糖。 | |||
T35795 |
Lactisole
na-PMP,2-(4-甲氧基苯氧基)丙酸 |
Taste receptor | Metabolism |
Lactisole (na-PMP) 是葡萄糖感应受体的抑制剂。 | |||
T69261 |
2-Pmp-PA
|
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2-Pmp-PA is a taste modulator that inhibits sweetness. | |||
T77989 |
Nα,Nα-Bis(carboxymethyl)-L-lysine
|
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Nα,Nα-Bis(carboxymethyl)-L-lysine作为bitter taste receptor 4的一种竞争性抑制剂,其IC50值为59 nM,适用于苦受体相关领域的科学研究。 | |||
T72009 |
N-Phenylthiourea
|
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N-Phenylthiourea is a tyrosinase inhibitor and building block. It increases the susceptibility of SK-MEL-188 melanoma cells in melanogenesis-inducing conditions to γ-radiation-induced cytotoxicity when used at a concentration of 0.01 μM. N-Phenylthiourea has been used as a precursor in the synthesis of compounds with antibacterial and antifungal activities. It has also been used as a genetic marker for taste because only some people detect it as a bitter taste. | |||
T38416 |
Adenosine 5'-succinate
|
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Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate. | |||
T82315 |
GIV3727
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GIV3727 是 hTAS2R 苦味受体的拮抗剂,能够抑制糖精与安赛蜜对 hTAS2R31 的活化作用,有效改善食品、饮料和药品的苦味特性。 | |||
T82186 |
Homoglutathione
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Homoglutathione,一种在真核生物中普遍存在且不可或缺的三肽,主要功能与细胞的氧化还原调节相关,并具有味觉调节作用。 | |||
T72532 |
Ethylhydrocupreine
Optochin |
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Ethylhydrocupreine (Optochin) 是一种具有抗菌作用的奎宁衍生物,具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine 还具有抗Plasmodiumfalciparum 的抗疟活性,IC50为 25.75 nM。Ethylhydrocupreine 是一种Gallus gallus2 受体 (ggTas2r1,ggTas2r2和ggTas2r7) 激动剂。 | |||
T10560 |
P2X3 antagonist 34
BLU-5937 |
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P2X3 antagonist 34 是一种对P2X3同型三聚体受体具有高效性、选择性和口服活性的拮抗剂,其IC50值针对人类P2X3、大鼠P2X3及豚鼠P2X3分别为25 nM、92 nM和126 nM。相比之下,该化合物对人类、大鼠和豚鼠的P2X2/3异三聚体受体展现低活性。P2X3 antagonist 34 显著具有抗咳功效,同时不会影响味觉。 | |||
T37476 |
Cyclo(L-Phe-L-Val)
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Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78480 |
24-Epicastasterone
24-epi-Castasterone |
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24-Epicastasterone (24-epi-Castasterone) 是从 Hydrodictyon reticulatum 中提取的天然油菜素内酯类化合物。 | |||
T40815 |
δ-Decalactone
|
Others | Others |
δ-Decalactone 存在于脱脂奶粉和水果中,具有甜味。 | |||
T2S1992 |
Perillartine
Perilla sugar,Peryllartine,紫苏葶,DL-Perillartine |
Others; Endogenous Metabolite | Metabolism; Others |
Perillartine (DL-Perillartine) 是甜味剂,能够激活味觉受体 1 型成员 2 。 | |||
TN7073 |
3-Feruloyl-4-caffeoylquinic acid
|
Others | Others |
3-Feruloyl-4-caffeoylquinic acid 是一种绿原酸异构体。绿原酸是相关的咖啡品质标志、味道和香气前体以及重要的生物活性化合物。 | |||
T2719 |
Succinic acid
Asuccin,Amber acid,琥珀酸,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid |
Endogenous Metabolite | Metabolism |
Succinic acid (1,2-Ethanedicarboxylic acid) 是无氧代谢的发酵产物,也是三羧酸循环的中间产物。 | |||
T3946 |
Octanoic acid
Caprylic acid,辛酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Octanoic acid (Caprylic acid) 天然存在于椰子和母乳中。它是一种油性液体,带有些许腐臭味,能用于酯类香料和染料的生产。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
TN3796 |
Dehydrobruceantinol
|
Others | Others |
Dehydrobruceantinol shows bitter taste and has antileukemic activity. | |||
TN1943 |
Momordicoside G
|
Others | Others |
Momordicosides K and L, the main bitter taste triterpene glycosides in Bitter melon; and bitter melon has been reported to have hypoglycemic, anti atherogenic and anti HIV activities. | |||
T39614 |
Mogroside VI A
|
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Mogroside VI A is a saccharide compound, an isomer of Mogroside VI, that has been extracted from the Luo Han Guo plant. It possesses inherent sweetness properties. Mogroside VI A holds potential for application in sweetener and taste modifier studies. | |||
T66083 | Dulcitol | ||
Dulcitol is a sugar alcohol and slightly sweet tastant for human taste cells. | |||
TN4469 |
Lyoniresinol
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Lyoniresinol 是一种从 Tarenna attenuata 分离出来的木质素,具有清除自由基的活性(IC50为82.4μM)和 DPPH 的抗氧化活性,显示出抗黑色素生成活性。Lyoniresinol 有强烈的苦味,而其对映体(-)-Lyoniresinol 是无味的。 | |||
T82284 |
Glycyrrhizin-6′′-methylester
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Glycyrrhizin-6′′-methylester (compound 22) 是从甘草根中分离的一种甘草皂苷,能参与葡萄糖醛酸甲酯的生成,赋予其甜味和甘草特有风味,但不具苦味。该化合物的研究强调了糖苷锥结合葡萄糖醛酸的游离羧基在形成天然甜味和甘草味觉中的关键作用。 |