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19

抑制剂 & 化合物

13

天然产物

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Cat. No. Product Name Target Signaling Pathways
T40417 Ethylhydrocupreine hydrochloride

Optochin hydrochloride,乙氢去甲奎宁盐酸盐;奥普托欣盐酸盐

Antibacterial; Parasite Microbiology/Virology
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物,具有抗菌作用,可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性,对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1,ggTas2r2和ggTas2r7) 激动剂。
T1499 Dutasteride

GG 745,Avodart,度他雄胺,GI 198745

Apoptosis; Reductase Apoptosis; Endocrinology/Hormones; Metabolism
Dutasteride (GI 198745) 是一种 5α 还原酶同工酶抑制剂,还可能因其结构域 DHT 相似对雄激素受体产生脱靶效应。
T11040 Dihydro Dutasteride

Others Others
Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is an effective inhibitor of five α-reductase isozymes.
T10179 5β-​Dutasteride

Others Others
5β-Dutasteride is the S configuration of Dutasteride. It is a potent inhibitor of both 5 alpha-reductase isozymes.
T34373 RO5166017

RO 5166017,RO-5166017

Others Others
RO5166017 是一种具有口服活性、高效性和选择性的痕量胺相关受体 1(TAAR1)激动剂,可用于研究条件性味觉厌恶额神经障碍。
T28258L Org 13011

5-HT Receptor GPCR/G Protein; Neuroscience
Org 13011 具有中枢神经系统活性,通过介导 5-HT 1A受体可诱导条件性味觉厌恶。
T9367 3-(Trifluoromethyl)benzaldehyde

3-三氟甲基苯甲醛,3-Trifluoromethylbenzaldehyde

Others Others
3-(Trifluoromethyl)benzaldehyde (3-Trifluoromethylbenzaldehyde) 有强烈的甜味,被用作调味剂,香水和化妆品的生产,以及作为中间体合成各种化合物。
TP2500 Cholecystokinin (26-33) free acid

CCK (26-33) free acid

cholecystokinin GPCR/G Protein
Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分, 是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体,可诱导大鼠轻度味觉厌恶条件反射。
T22352 L-Gulose

Others; Endogenous Metabolite Metabolism; Others
L-Gulose 是一种合成维生素 C 的生物中间体,是一种 L-sorbosone 的呋喃糖形式,是L 己糖。
T35795 Lactisole

na-PMP,2-(4-甲氧基苯氧基)丙酸

Taste receptor Metabolism
Lactisole (na-PMP) 是葡萄糖感应受体的抑制剂。
T69261 2-Pmp-PA

2-Pmp-PA is a taste modulator that inhibits sweetness.
T77989 Nα,Nα-Bis(carboxymethyl)-L-lysine

Nα,Nα-Bis(carboxymethyl)-L-lysine作为bitter taste receptor 4的一种竞争性抑制剂,其IC50值为59 nM,适用于苦受体相关领域的科学研究。
T72009 N-Phenylthiourea

N-Phenylthiourea is a tyrosinase inhibitor and building block. It increases the susceptibility of SK-MEL-188 melanoma cells in melanogenesis-inducing conditions to γ-radiation-induced cytotoxicity when used at a concentration of 0.01 μM. N-Phenylthiourea has been used as a precursor in the synthesis of compounds with antibacterial and antifungal activities. It has also been used as a genetic marker for taste because only some people detect it as a bitter taste.
T38416 Adenosine 5'-succinate

Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate.
T82315 GIV3727

GIV3727 是 hTAS2R 苦味受体的拮抗剂,能够抑制糖精与安赛蜜对 hTAS2R31 的活化作用,有效改善食品、饮料和药品的苦味特性。
T82186 Homoglutathione

Homoglutathione,一种在真核生物中普遍存在且不可或缺的三肽,主要功能与细胞的氧化还原调节相关,并具有味觉调节作用。
T72532 Ethylhydrocupreine

Optochin

Ethylhydrocupreine (Optochin) 是一种具有抗菌作用的奎宁衍生物,具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine 还具有抗Plasmodiumfalciparum 的抗疟活性,IC50为 25.75 nM。Ethylhydrocupreine 是一种Gallus gallus2 受体 (ggTas2r1,ggTas2r2和ggTas2r7) 激动剂。
T10560 P2X3 antagonist 34

BLU-5937

P2X3 antagonist 34 是一种对P2X3同型三聚体受体具有高效性、选择性和口服活性的拮抗剂,其IC50值针对人类P2X3、大鼠P2X3及豚鼠P2X3分别为25 nM、92 nM和126 nM。相比之下,该化合物对人类、大鼠和豚鼠的P2X2/3异三聚体受体展现低活性。P2X3 antagonist 34 显著具有抗咳功效,同时不会影响味觉。
T37476 Cyclo(L-Phe-L-Val)

Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-...

化合物

Ethylhydrocupreine hydrochloride
Cat.No: T40417
Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐;奥普托欣盐酸盐
Target: Antibacterial, Parasite
Dutasteride
Cat.No: T1499
Synonym: GG 745,Avodart,度他雄胺,GI 198745
Target: Apoptosis, Reductase
Dihydro Dutasteride
Cat.No: T11040
Synonym:
Target: Others
5β-​Dutasteride
Cat.No: T10179
Synonym:
Target: Others
RO5166017
Cat.No: T34373
Synonym: RO 5166017,RO-5166017
Target: Others
Org 13011
Cat.No: T28258L
Synonym:
Target: 5-HT Receptor
3-(Trifluoromethyl)benzaldehyde
Cat.No: T9367
Synonym: 3-三氟甲基苯甲醛,3-Trifluoromethylbenzaldehyde
Target: Others
Cholecystokinin (26-33) free acid
Cat.No: TP2500
Synonym: CCK (26-33) free acid
Target: cholecystokinin
L-Gulose
Cat.No: T22352
Synonym:
Target: Others, Endogenous Metabolite
Lactisole
Cat.No: T35795
Synonym: na-PMP,2-(4-甲氧基苯氧基)丙酸
Target: Taste receptor
2-Pmp-PA
Cat.No: T69261
Synonym:
Target:
Nα,Nα-Bis(carboxymethyl)-L-lysine
Cat.No: T77989
Synonym:
Target:
N-Phenylthiourea
Cat.No: T72009
Synonym:
Target:
Adenosine 5'-succinate
Cat.No: T38416
Synonym:
Target:
GIV3727
Cat.No: T82315
Synonym:
Target:
Homoglutathione
Cat.No: T82186
Synonym:
Target:
Ethylhydrocupreine
Cat.No: T72532
Synonym: Optochin
Target:
P2X3 antagonist 34
Cat.No: T10560
Synonym: BLU-5937
Target:
Cyclo(L-Phe-L-Val)
Cat.No: T37476
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T78480 24-Epicastasterone

24-epi-Castasterone

24-Epicastasterone (24-epi-Castasterone) 是从 Hydrodictyon reticulatum 中提取的天然油菜素内酯类化合物。
T40815 δ-Decalactone

Others Others
δ-Decalactone 存在于脱脂奶粉和水果中,具有甜味。
T2S1992 Perillartine

Perilla sugar,Peryllartine,紫苏葶,DL-Perillartine

Others; Endogenous Metabolite Metabolism; Others
Perillartine (DL-Perillartine) 是甜味剂,能够激活味觉受体 1 型成员 2 。
TN7073 3-Feruloyl-4-caffeoylquinic acid

Others Others
3-Feruloyl-4-caffeoylquinic acid 是一种绿原酸异构体。绿原酸是相关的咖啡品质标志、味道和香气前体以及重要的生物活性化合物。
T2719 Succinic acid

Asuccin,Amber acid,琥珀酸,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid

Endogenous Metabolite Metabolism
Succinic acid (1,2-Ethanedicarboxylic acid) 是无氧代谢的发酵产物,也是三羧酸循环的中间产物。
T3946 Octanoic acid

Caprylic acid,辛酸

Others; Endogenous Metabolite Metabolism; Others
Octanoic acid (Caprylic acid) 天然存在于椰子和母乳中。它是一种油性液体,带有些许腐臭味,能用于酯类香料和染料的生产。
T4838 (S)-Malic acid

L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸

Others; Endogenous Metabolite Metabolism; Others
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。
TN3796 Dehydrobruceantinol

Others Others
Dehydrobruceantinol shows bitter taste and has antileukemic activity.
TN1943 Momordicoside G

Others Others
Momordicosides K and L, the main bitter taste triterpene glycosides in Bitter melon; and bitter melon has been reported to have hypoglycemic, anti atherogenic and anti HIV activities.
T39614 Mogroside VI A

Mogroside VI A is a saccharide compound, an isomer of Mogroside VI, that has been extracted from the Luo Han Guo plant. It possesses inherent sweetness properties. Mogroside VI A holds potential for application in sweetener and taste modifier studies.
T66083 Dulcitol

Dulcitol is a sugar alcohol and slightly sweet tastant for human taste cells.
TN4469 Lyoniresinol

Lyoniresinol 是一种从 Tarenna attenuata 分离出来的木质素,具有清除自由基的活性(IC50为82.4μM)和 DPPH 的抗氧化活性,显示出抗黑色素生成活性。Lyoniresinol 有强烈的苦味,而其对映体(-)-Lyoniresinol 是无味的。
T82284 Glycyrrhizin-6′′-methylester

Glycyrrhizin-6′′-methylester (compound 22) 是从甘草根中分离的一种甘草皂苷,能参与葡萄糖醛酸甲酯的生成,赋予其甜味和甘草特有风味,但不具苦味。该化合物的研究强调了糖苷锥结合葡萄糖醛酸的游离羧基在形成天然甜味和甘草味觉中的关键作用。

天然产物

24-Epicastasterone
Cat.No: T78480
Synonym: 24-epi-Castasterone
Target:
δ-Decalactone
Cat.No: T40815
Synonym:
Target: Others
Perillartine
Cat.No: T2S1992
Synonym: Perilla sugar,Peryllartine,紫苏葶,DL-Perillartine
Target: Others, Endogenous Metabolite
3-Feruloyl-4-caffeoylquinic acid
Cat.No: TN7073
Synonym:
Target: Others
Succinic acid
Cat.No: T2719
Synonym: Asuccin,Amber acid,琥珀酸,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid
Target: Endogenous Metabolite
Octanoic acid
Cat.No: T3946
Synonym: Caprylic acid,辛酸
Target: Others, Endogenous Metabolite
(S)-Malic acid
Cat.No: T4838
Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸
Target: Others, Endogenous Metabolite
Dehydrobruceantinol
Cat.No: TN3796
Synonym:
Target: Others
Momordicoside G
Cat.No: TN1943
Synonym:
Target: Others
Mogroside VI A
Cat.No: T39614
Synonym:
Target:
Dulcitol
Cat.No: T66083
Synonym:
Target:
Lyoniresinol
Cat.No: TN4469
Synonym:
Target:
Glycyrrhizin-6′′-methylester
Cat.No: T82284
Synonym:
Target:
TargetMol Loading
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