Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lactisole (na-PMP) 是葡萄糖感应受体的抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 166 | 现货 | ||
500 mg | ¥ 366 | 现货 | ||
1 g | ¥ 528 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 118 | 现货 |
产品描述 | Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor |
靶点活性 | Sweet taste receptor:∼4 mM |
体外活性 | In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ~4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1]. |
别名 | na-PMP, 2-(4-甲氧基苯氧基)丙酸 |
分子量 | 218.18 |
分子式 | C10H11NaO4 |
CAS No. | 150436-68-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL
DMSO: 10 mg/mL
DMF: 20 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lactisole 150436-68-3 Metabolism Taste receptor na-PMP 2-(4-甲氧基苯氧基)丙酸 Inhibitor inhibitor inhibit