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22

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T33716	Norathiol NOX 100,NOX100,NOX-100
	Norathiol(NOX-100) is nitric oxide (NO) scavenging agent that may be used to prevent hypotension during hemodialysis and septic shock.
TP1412	RNAIII-inhibiting peptide TFA RNAIII-inhibiting peptide(TFA),L-酪氨酰-L-丝氨酰-L-脯氨酰-L-色氨酰-L-苏氨酰-L-天冬氨酰胺酰-L-苯丙氨酸	Antibacterial	Microbiology/Virology
	RNAIII-inhibiting peptide TFA (RNAIII-inhibiting peptide(TFA))(228544-21-6 free base) 抑制肽（TFA）抑制金黄色葡萄球菌，对蜂窝织炎、角膜炎、化脓性关节炎、骨髓炎和乳腺炎等疾病有效。
T37292	M62812	TLR	Immunology/Inflammation
	M62812是一种 TLR4抑制剂，可在 HEK239细胞中抑制 LPS 诱导的NF-κB 活化。
T76251L	Ac-FEID-CMK TFA	Pyroptosis	Apoptosis; Immunology/Inflammation
	Ac-FEID-CMK TFA 是一种选择性斑马鱼 GSDMEb 衍生肽抑制剂，可减少感染性休克的死亡率和肾损伤。Ac-FEID-CMK TFA 在体内可抑制焦亡，缓解败血性 AKI (急性肾损伤)，抑制 caspy2 介导的非典型炎症小体通路发挥作用。
T13920L	Terlipressin Acetate Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素	Vasopressin Receptor	GPCR/G Protein
	Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂，对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
T10492	BD-AcAc 2 Ketone Ester	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BD-AcAc 2 (Ketone Ester) 是一种酮单酯，是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。
T21967	MEG hemisulfate Mercaptoethylguanidine hemisulfate	NOS	Immunology/Inflammation
	MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂，在组织匀浆中抑制 iNOS，ecNOS 和 bNOS 的 EC50 值分别为 11.5，110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂，可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用，包括缺血/再灌注损伤，牙周炎，失血性休克，炎性肠病以及内毒素和败血性休克。
T70480	FPL-65447 hydrochloride
	FPL-65447 hydrochloride is a selective D1 receptor agonist that has potential for the acute treatment of renal and cardiac failure and of sepsis and septic shock.
T28921	Tanogitran BIBT 986,BIBT986,BIBT-986
	Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock.
T76733	Enibarcimab
	Enibarcimab 是一种人源化小鼠单克隆免疫球蛋白 G1 (IgG1) 抗体，可用于急性心衰、COVID 2019 感染和感染性休克的研究。
T78802	SIRT5 inhibitor 6	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT5 Inhibitor6为一种SIRT5选择性抑制剂，表现出底物竞争性，其IC50值为3.0 μM，展现了在脓毒性AKI疗法研究中的应用潜力。
T78561	M62812 free base
	M62812 (free base) 是一种TLR4信号转导抑制剂，能够抑制内皮细胞和白细胞的活化，有效预防小鼠致死性感染性休克，适用于脓毒症的研究。
T76251	Ac-FEID-CMK
	Ac-FEID-CMK 是一种有效的斑马鱼特异性GSDMEb 衍生肽抑制剂。Ac-FEID-CMK 可减轻感染性休克的死亡率和肾损伤。Ac-FEID-CMK 在体内可抑制焦亡，减轻败血性 AKI (急性肾损伤)。Ac-FEID-CMK 可抑制 caspy2 介导的非典型炎症小体通路。
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
T73353	NOS-IN-3
	NOS-IN-3 是一个强效的、选择性的由 imidamide 衍生的NOS 抑制剂，对iNOS 的IC50值为20 µM。 NOS-IN-3 不抑制eNOS，几乎没有毒性，可用于研究治疗可诱导亚型涉及的疾病，如感染性休克。
T82621	D359-0396	NOD-like Receptor (NLR)	Immunology/Inflammation
	D359-0396 是一种口服活性的 NLRP3 炎性体抑制剂，能有效抑制巨噬细胞焦亡（pyroptosis）以及 IL-1β 的释放，并阻止 NLRP3 和 ASC 的寡聚化，抑制 GSDMD 的裂解。该化合物在动物模型中能减轻小鼠的 EAE 症状，并提高感染性休克后的小鼠存活率。
T79733	NLRP3-IN-20	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-20（compound 11）是一款口服活性的NLRP3炎症小体抑制剂，其抑制IL-1β分泌的IC50值为25 nM。该化合物展现出卓越的药代动力学性质，并在非酒精性脂肪性肝炎、致命性感染性休克以及结肠炎模型中证明了其显著疗效。
T35598	Neuromedin U-25 (human) (trifluoroacetate salt)
	Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ...
T82189	HMGB1-IN-2
	HMGB1-IN-2 (compound 15) 是一种针对高度保守的核蛋白 HMGB1 的抑制剂，其在 RAW264.7 细胞中展现出 NO 抑制活性，IC50 为 20.2 μM。 HMGB1-IN-2 (30 μM) 能够减少 IL-1β、TNF-α、caspase-1 p20 的表达，并抑制 NF-κB p65 的磷酸化作用，显示出抗凋亡特性。在脓毒症急性肾损伤模型的小鼠中，HMGB1-IN-2（15 mg/kg；腹腔注射）可有效减轻肾脏伤害。此外，HMGB1-IN-2 对 Huh7 细胞和 A549 细胞的 IC50 分别为 77.0 μM 和 82.0 μM。
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...

化合物

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Cat.No: T33716

Synonym: NOX 100,NOX100,NOX-100

RNAIII-inhibiting peptide TFA

Cat.No: TP1412

Synonym: RNAIII-inhibiting peptide(TFA),L-酪氨酰-L-丝氨酰-L-脯氨酰-L-色氨酰-L-苏氨酰-L-天冬氨酰胺酰-L-苯丙氨酸

Target: Antibacterial

Cat.No: T37292

Target: TLR

Ac-FEID-CMK TFA

Cat.No: T76251L

Target: Pyroptosis

Terlipressin Acetate

Cat.No: T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素

Target: Vasopressin Receptor

Cat.No: T10492

Synonym: Ketone Ester

Target: Reactive Oxygen Species

MEG hemisulfate

Cat.No: T21967

Synonym: Mercaptoethylguanidine hemisulfate

Target: NOS

FPL-65447 hydrochloride

Cat.No: T70480

Cat.No: T28921

Synonym: BIBT 986,BIBT986,BIBT-986

Cat.No: T76733

SIRT5 inhibitor 6

Cat.No: T78802

Target: Sirtuin

M62812 free base

Cat.No: T78561

Cat.No: T76251

Cat.No: T37302

Cat.No: T73353

Cat.No: T82621

Target: NOD-like Receptor (NLR)

Cat.No: T79733

Target: NOD-like Receptor (NLR)

Neuromedin U-25 (human) (trifluoroacetate salt)

Cat.No: T35598

Cat.No: T82189

Cat.No: T35406

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Cat. No.	Product Name	Target	Signaling Pathways
TN1686	Ginsenoside Rg4 人参皂苷 RG4	Antibacterial	Microbiology/Virology
	Ginsenoside Rg4 是分离自Panax ginsengC. A. Meyer 叶子中的一种人参三醇型人参皂苷。人参三醇型人参皂苷具有多种生物活性，包括防腐，抗糖尿病，伤口愈合，免疫刺激和抗氧化活性等。
TN6774	Emodin 6-O-β-D-glucoside 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin	Others	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性，可用于研究动脉粥样硬化及糖尿病并发症。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。

天然产物

Ginsenoside Rg4

Cat.No: TN1686

Synonym: 人参皂苷 RG4

Target: Antibacterial

Emodin 6-O-β-D-glucoside

Cat.No: TN6774

Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Target: Others

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

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