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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8845	UTL-5g 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF	Apoptosis
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂，可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性，具有化学保护和肝脏放射保护作用。
T12684	Radioprotectin-1 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid	LPA Receptor	GPCR/G Protein
	Radioprotectin-1 是特异性的 LPA2 激动剂，对小鼠 LPA2 GPCR 的 EC50 为 25 nM，具有辐射保护和辐射缓解作用。
T6381	Amifostine trihydrate Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Amifostine trihydrate (WR2721) 是一种广谱细胞保护剂和辐射防护剂。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的HIF-α1和p53诱导剂。它通过清除氧衍生的自由基来保护细胞免受损伤。它可降低肾脏毒性并具有抗血管生成作用。
T29655	Adeturon
	Adeturon can play radioprotective effect.
T37538	Amifostine thiol
	Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3].
T13862L	Recilisib sodium Brand name: Ex-RAD,ON 01210.Na,ON01210,ON-01210
	Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution patterns in cancer cells subjected to radiation therapy, and it has been identified as a potential candidate for radiation protection studies. It appears tha
T78101	Zymosan A Zymosan A from Saccharomyces cerevisiae
	Zymosan A（来自酿酒酵母的Zymosan A）是一种针对TLR2的激动剂，能够预防及抑制由IR引起的肠道伤害。该化合物显著增强了对辐射的防护能力，并能够保护小鼠免受辐射引起的肠损伤。此外，Zymosan A还能促进受IR损伤的肠干细胞（ISCs）的再生。

化合物

UTL-5g

Cat.No: T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Radioprotectin-1

Cat.No: T12684

Synonym: 5-chloro-2-[4-(1,3-dioxobenzo[de]isoquinolin-2-yl)butylsulfamoyl]benzoic acid

Target: LPA Receptor

Amifostine trihydrate

Cat.No: T6381

Synonym: Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

Synonym: Brand name: Ex-RAD,ON 01210.Na,ON01210,ON-01210

Target:

Zymosan A

Cat.No: T78101

Synonym: Zymosan A from Saccharomyces cerevisiae

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T2755	Rhoifolin 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy	Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors
	Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌，胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
TN6510	Cordifolioside A
	Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.