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Search Results for " programmed cell death "

31

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12379	PD-1-IN-22	Others; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Others
	PD-1-IN-22 是一种有效的程序性细胞死亡 1 (PD-1)/程序性细胞死亡配体1 (PD-L1) 相互作用的抑制剂，IC50 为 92.3 nM。
T77346	2-aminobenzo[d]thiazol-6-ol
	2-aminobenzo[d]thiazol-6-ol 具有抗菌、抗氧化和抗癌特性，可通过诱导细胞凋亡或程序性细胞死亡来抑制某些癌细胞系的活性。
T9907	Nivolumab	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Nivolumab 是PD-1抗体类抑制剂，可用于研究晚期（转移性）非小细胞肺癌。
T83970	IMMH 010 maleate YPD-30 maleate	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	IMMH 010 maleate (YPD-30 maleate) 是一种可口服的程序性细胞死亡配体 1 抑制剂，具有潜在的抗肿瘤活性，可用于研究神经系统疾病和晚期恶性实体瘤。
T50016	2-amino-4-methyl-1,3-thiazole-5-carbohydrazide	Others	Others
	2-amino-4-methyl-1,3-thiazole-5-carbohydrazide （AMTCH）具有抗肿瘤活性，通过诱导细胞凋亡或细胞程序性死亡抑制癌细胞的生长，也具有抗细菌和真菌活性。
T76750	Cemiplimab REGN-2810,SAR-439684	Others	Others
	Cemiplimab (Anti-Human PD-1) 是一种针对程序性细胞死亡受体 1 （PD-1）的人单克隆抗体，也是一种检查点抑制剂，可阻断 PD-1/PD-L1 介导的 T 细胞抑制，可用于转移性癌症和鳞状细胞皮肤癌研究。
T40111L	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 是一种基于间苯二酚二Ph醚支架的程序性细胞死亡-1（PD-1）/程序性细胞死亡配体1（PD-L1）抑制剂, 抑制 PD-1/PD-L1 相互作用，IC50 值为 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可用于合成 PROTAC PD-1/PD-L1 degrader-1。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 具有抗癌活性。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可作为稀释剂，用于用于直接压缩制备片剂。
T12387	PD1-PDL1-IN 1	Others	Others
	PD1-PDL1-IN 1 is a potent inhibitor of programmed cell death 1 (PD-1),and used as immune modulator.
T70291	PCC0208018
	PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro.
T12377L	PD-1-IN-17 (TFA) (1673560-66-1 free base) PD-1-IN-17 (TFA)	Others	Others
	PD-1-IN-17 TFA is a inhibitor of programmed cell death-1 (PD-1) .
T61750	Anticancer agent 72
	Anticancer agent 72 (compound 8c) effectively inhibits the K+ channel, displaying significant potential as an anticancer treatment. Additionally, it induces apoptosis, a programmed cell death process [1].
T36523	Extracellular Death Factor
	Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing pop...
T80052	Cathepsin B
	Cathepsin B为一种半胱氨酸蛋白酶，涉及多种程序性细胞死亡（包括细胞凋亡、焦亡、铁亡、坏死亡及自噬性细胞死亡）。
T81928	Lipustobart	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Lipstobart是一种IgG4-kappa型抗PDCD1(程序性细胞死亡1, PD1,PD-1, CD279)的人源化单克隆抗体，具有免疫刺激和抗肿瘤活性。
T73630	PD1-PDL1-IN 1 TFA
	PD1-PDL1-IN 1 TFA（compound 16）是一种高效的程序性细胞死亡1（PD-1）抑制剂，具有免疫调节作用。
T36046	LH1306
	LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays). \|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibito...
T36047	LH1307
	LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays). \|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors o...
T63256	PD-1-IN-17 TFA
	PD-1-IN-17 TFA 是程序性细胞死亡-1 (PD-1) 的有效抑制剂，100 nM 的浓度能够抑制 92% 脾细胞增殖。
T77180	Retifanlimab
	Retifanlimab为一种抗程序性细胞死亡蛋白1(anti-PD-1)单克隆抗体(mAb)，主要用于胃食道腺癌(GEA)的研究。
T12377	PD-1-IN-17	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1-IN-17 是程序性细胞死亡 1 (PD-1) 的抑制剂。 PD-1-IN-17 在 100 nM 时抑制 92% 的脾细胞增殖。
T81979	KLA peptide
	KLA peptide 是具有生物活性的肽，为阳离子两亲性质的线粒体膜破坏肽。它通过破坏线粒体膜来诱导程序性细胞死亡，但不能穿过质膜。
T77178	Pucotenlimab
	Pucotenlimab (HX008) 为人源化免疫球蛋白 G4 (IgG4) 针对程序性细胞死亡蛋白 1(anti-PD-1)的单克隆抗体，应用于肿瘤研究。
T76714	Sugemalimab
	Sugemalimab 是一种针对程序性死亡配体1 (PD-L1) 的完整人源化IgG4 (免疫球蛋白G4) 单克隆抗体 (mAb)，展现出对非小细胞肺癌具有研究潜力的抗癌活性。
T33808	12-Oxo phytodienoic acid 12-Oxo-Phytodienoic acid,12-OPDA,12-oxo PDA,OPDA	Others	Others
	12-Oxo phytodienoic acid (12-oxo PDA) 是具有生物活性的 7-epi jasmonic acid 的直接前体。12-Oxo phytodienoic acid 在介导对病原体和害虫的抗性中起非依赖性作用。
T76936	Budigalimab
	Budigalimab (ABBV 181; PR 1648817) 是一种人源 IgG1单克隆抗体，靶向程序性细胞死亡 1 (PD-1) 受体。Budigalimab 具有 Fc 突变，从而减少了 Fc 受体相互作用和效应因子的抑制作用。
T80588	Bintrafusp alfa M7824,MSB0011359C
	Bintrafusp alfa (M 7824) 是高端双功能融合蛋白，融合了转化生长因子β受体II (TGF-βRII) 的细胞外域与人源IgG1单克隆抗体 (mAb) 致程序性细胞死亡配体阻断功能。该化合物主要用于癌症研究领域。
T60776	Anticancer agent 68
	Anticancer agent 68 is (Compound 12) 是一种抗癌剂。Anticancer agent 68 将细胞阻滞在 G2/M 期并诱导程序性细胞死亡。Anticancer agent 68 通过激活 p53 和 PTEN 诱导上调肿瘤抑制。
TP1947	P110
	Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro.
T36034	CAY10774
	CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs. 1.Konieczny, M., Musielak, B., Koc...
T82508	Eciskafusp alfa	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Eciskafusp alfa是一种针对程序性细胞死亡1(PDCD1，亦称PD-1)的顺式靶向IL2v免疫细胞因子。它优先选择抗原特异性干细胞样PD-1+ TCF-1+ CD8+ T细胞，并促使这些细胞分化成更高效的效应器细胞。Eciskafusp alfa主要用于癌症与慢性感染的研究领域。
T83724	TPP-1 hydrochloride Targeting PD-L1 Peptide
	TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时，以4 mg/kg的剂量给药，可减少小鼠异种移植模型中的肿瘤体积。

化合物

Cat.No: T12379

Target: Others, PD-1/PD-L1

2-aminobenzo[d]thiazol-6-ol

Cat.No: T77346

Cat.No: T9907

Target: PD-1/PD-L1

IMMH 010 maleate

Cat.No: T83970

Synonym: YPD-30 maleate

Target: PD-1/PD-L1

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide

Cat.No: T50016

Target: Others

Cat.No: T76750

Synonym: REGN-2810,SAR-439684

Target: Others

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Cat.No: T40111L

Target: PD-1/PD-L1

Cat.No: T12387

Target: Others

Cat.No: T70291

PD-1-IN-17 (TFA) (1673560-66-1 free base)

Cat.No: T12377L

Synonym: PD-1-IN-17 (TFA)

Target: Others

Anticancer agent 72

Cat.No: T61750

Extracellular Death Factor

Cat.No: T36523

Cat.No: T80052

Cat.No: T81928

Target: PD-1/PD-L1

PD1-PDL1-IN 1 TFA

Cat.No: T73630

Cat.No: T36046

Cat.No: T36047

Cat.No: T63256

Cat.No: T77180

Cat.No: T12377

Target: PD-1/PD-L1

Cat.No: T81979

Cat.No: T77178

Cat.No: T76714

12-Oxo phytodienoic acid

Cat.No: T33808

Synonym: 12-Oxo-Phytodienoic acid,12-OPDA,12-oxo PDA,OPDA

Target: Others

Cat.No: T76936

Bintrafusp alfa

Cat.No: T80588

Synonym: M7824,MSB0011359C

Anticancer agent 68

Cat.No: T60776

Cat.No: TP1947

Cat.No: T36034

Eciskafusp alfa

Cat.No: T82508

Target: PD-1/PD-L1

TPP-1 hydrochloride

Cat.No: T83724

Synonym: Targeting PD-L1 Peptide

Cat. No.	Product Name	Target	Signaling Pathways
T4004	Concanavalin A	Apoptosis	Apoptosis
	Concanavalin A 是 Ca2+/Mn2+依赖性和甘露糖/葡萄糖结合植物凝集素。它能够促使程序性细胞死亡。
T21936	M50054 2,2′-亚甲基双(1,3-环己二酮)	Caspase	Apoptosis; Proteases/Proteasome
	M50054 是一种有效的细胞凋亡抑制剂，可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。它抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化，IC50为 79 μg/mL。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
T4881	Phosphorylethanolamine O-Phosphorylethanolamine,乙醇胺磷酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体，也是磷脂分解的产物。与其他器官相比，大脑中磷酸单酯的含量要高得多。在大脑发育过程中，磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯，在阿尔茨海默病患者的大脑中减少。
T71471	Chrysotobibenzyl
	Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM)-- and inhibit the growth of lung cancer cells in anchorage-independent condition. Preliminary data obtained discloses the inhibitory effect on cancer cell metastasis of the isolated compounds and may provide a new approach for cancer drug development.
T4558	Trioxsalen 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物，与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂，可用于激光激活定位的基因组链间交联可视化。

天然产物

Cat.No: T4004

Target: Apoptosis

Cat.No: T21936

Synonym: 2,2′-亚甲基双(1,3-环己二酮)

Target: Caspase

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Phosphorylethanolamine

Cat.No: T4881

Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯

Target: Others, Endogenous Metabolite

Chrysotobibenzyl

Cat.No: T71471

Cat.No: T4558

Synonym: 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

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