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Search Results for " preadipocytes "

3

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T79678	PPARγ-IN-2	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARγ-IN-2 (Compound 5a) 是一款PPARγ抑制剂，可在3T3-L1前脂肪细胞中抑制TG积累，EC50值为0.106 μM。该化合物能够减轻HFC诱导的肥胖及相关代谢综合症状，同时降低脂肪组织内脂质的堆积。
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in a...

化合物

Cat.No: T79678

Target: PPAR

Cat.No: T71328

Cat.No: T36830

Cat. No.	Product Name	Target	Signaling Pathways
T5552	Methyl cinnamate	Tyrosinase; Antibacterial; AMPK	Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Methyl cinnamate 是花椒的有效成分，也是一种天然香料。它是一种防止食品褐变的酪氨酸酶抑制剂，具有抗菌活性。它通过由 CaMKK2-AMPK 信号途径介导的机制具有抗脂活性。
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
T2P2923	Stearic acid 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid	Phosphatase; Endogenous Metabolite	Metabolism
	Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。
TC0028	Dihydrosamidin	Others	Others
	Dihydrosamidin 是一种天然产物。它对3T3-L1前脂肪细胞中三酰基甘油积累的抑制作用。
TN4213	Hirsutenone	ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-...

天然产物

Methyl cinnamate

Cat.No: T5552

Target: Tyrosinase, Antibacterial, AMPK

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Cat.No: T2P2923

Synonym: 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid

Target: Phosphatase, Endogenous Metabolite

Cat.No: TC0028

Target: Others

Cat.No: TN4213

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

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