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Search Results for " polymer "

94

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18365	Mp-polymer ester	Others	Others
	Mp-polymer ester is a noncleavable antibody-drug conjugates (ADCs) linker typically employed in the synthesis of ADCs[1].
T20188	Polynoxylin Formaldehyde, urea polymer,Gabrite,Hygromull,HSDB 7203
	Polynoxylin is an antiseptic. It is used for local treatment of the skin and the mouth.
T7022	PEG300 聚乙二醇,Polyethylene glycol 300	Others	Others
	PEG300 (Polyethylene glycol 300) 是一种由乙二醇重复单元形成的聚合物，具有水溶性、低免疫原性和生物相容性。PEG300 是一种分子量为300的中性聚合物。
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T80644	DNA polymerase-IN-1	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	DNA polymerase-IN-1 作为DNA聚合酶抑制剂，展现出对肿瘤细胞的抗增殖活性，其半抑制浓度（IC50）为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶，IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性，可用于研究氧化损伤和结直肠癌。
T77647	Tubulin polymerization-IN-43	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。
T74630	RNA polymerase II-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RNA polymerase II-IN-1（compound 19iv）是一款鹅膏毒素类化合物，能够抑制RNA聚合酶II（Pol II），其半抑制浓度IC50为36.66 nM。该化合物相较于α-Amanitin，对癌细胞展现出更高的细胞毒性，而对正常细胞的毒性较低。
T62121	Tubulin polymerization-IN-3
	Tubulin polymerization-IN-3 是一种有效的微管蛋白聚合抑制剂 (IC50: 3.84 μM)，能够诱导结肠癌细胞凋亡。
T82536	DNA polymerase-IN-4
	DNA polymerase-IN-4 (Compd 5c)，香豆素衍生物，显示出抗逆转录病毒活性，IC50为134.22 μM。
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。
T79887	Tubulin polymerization-IN-49
	Tubulin polymerization-IN-49 (compound 12d) 是一种抑制微管蛋白聚合的有效化合物。它通过结合到微管蛋白的秋水仙碱位点来抑制其聚合。此外，Tubulin polymerization-IN-49 能够诱导细胞周期在 G2/M 期停滞并触发细胞凋亡，表现出对抗癌的活性，能够预防肿瘤的生成及抑制肿瘤增殖和血管生成。
T79922	Taq DNA polymerase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Taq DNA 聚合酶是一种在PCR过程中广泛使用的耐热性酶，由Thermus aquaticus细菌产生，其功能是在高温下合成DNA链。
T61084	Tubulin polymerization-IN-37
	Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
T62206	Tubulin polymerization-IN-19
	Tubulin aggregation-IN-19 (compound 4) 是一种有效 tubulin 聚合抑制剂，对乳腺癌和耐药结肠癌表现出研究潜力。
T63836	Tubulin polymerization-IN-7
	Tubulin aggregation-IN-7 是有效的 tubulin 聚合抑制剂，对癌症疾病表现出研究潜力。
T62971	Tubulin polymerization-IN-16
	Tubulin aggregation-IN-16 (compound 5g) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞有效 (IC50: 0.084-0.221 μM)。Tubulin aggregation-IN-16 能有效地破坏微管/管蛋白的动态，诱导 SGC-7901 细胞的细胞周期阻滞在 G2/M 期。
T62498	Tubulin polymerization-IN-20
	Tubulin aggregation-IN-20 (compound 11) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-20 具有潜力进行乳腺癌和耐药结肠癌的研究。
T61600	Tubulin polymerization-IN-10
	Tubulin polymerization-IN-10 is a highly potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 4.25±0.75 μM. It possesses significant anti-tumor properties [1].
T63111	Tubulin polymerization-IN-33
	Tubulin polymerization-IN-33 是一种 [1,2] 恶唑洛异吲哚微管蛋白聚合的抑制剂，能够较好的抗 NCI 系列癌细胞的增殖。
T80923	Tubulin polymerization-IN-53
	Tubulin polymerization-IN-53 是一种β-tubulin聚合的抑制剂，能够阻断细胞周期于G2/M阶段。对MDA-MB-231细胞系显示出抗增殖作用，其IC50为3.24 μM。
T79268	Tubulin polymerization-IN-42
	Tubulin polymerization-IN-42（compound 10j）是一种具有抗癌活性的吲哚取代呋喃酮类微管蛋白聚合抑制剂。
T60802	Tubulin polymerization-IN-2
	Tubulin polymerization-IN-2 为针对β-微管蛋白的强效抗癌分子，IC50 值为0.92 μM。该分子在多种细胞系中，包括白血病、非小细胞肺癌、肾癌、前列腺癌及乳腺癌细胞中展现出显著的抑制效果。
T79308	DNA polymerase-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-3 (Compd 5b) 为香豆素衍生物，对 Taq DNA聚合酶具有抑制活性，适用于增值性疾病研究。
T79766	Tubulin polymerization-IN-52
	Tubulin polymerization-IN-52 (compound SC23)是一种tubulin聚合抑制剂，具有2.9 μM的IC50值。
T62135	Tubulin polymerization-IN-25
	Tubulin polymerization-IN-25 是一种选择性的、双重 tubulin polymerization (IC50: 1.11 μM) 和 farnesyl transferase (FTase) (IC50: 0.39 μM) 抑制剂。Tubulin polymerization-IN-25 对癌细胞表现出细胞毒性，能够阻断细胞增殖。
T63580	Tubulin polymerization-IN-21
	Tubulin polymerization-IN-21 是微管蛋白聚合抑制剂，能够破坏细胞完整性和影响葡萄糖代谢，具有抗癌作用。
T62349	Tubulin polymerization-IN-8
	Tubulin aggregation-IN-8 (compound IIc) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-8 浓度依赖性地导致 HCT116 肿瘤细胞 G2/M 期细胞周期停滞，并显示显着抑制微管蛋白聚合，IC50值为 12.7 μM。Tubulin aggregation-IN-8 具有研究癌症疾病的潜力。
T61532	Tubulin polymerization-IN-6
	Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Additionally, Tubulin polymerization-IN-6 has been found to effectively hinder tumor growth in HT29 xenograft Balb/c nude mice [1].
T60902	Tubulin polymerization-IN-31
	Tubulin polymerization-IN-31 (Compound 4c) 具有抗癌活性，并诱导癌细胞凋亡。Tubulin polymerization-IN-31 是微管蛋白聚合的抑制剂，IC50 值为 3.64 μM。
T63849	Tubulin polymerization-IN-34
	Tubulin polymerization-IN-34 是 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂，能够高度选择边缘区淋巴瘤 VL51 细胞系。
T62369	Tubulin polymerization-IN-17
	Tubulin aggregation-IN-17 (compound 23g) 是一种 tubulin 聚合的有效抑制剂。Tubulin aggregation-IN-17 具有微管蛋白解聚作用，能够诱导细胞凋亡并抑制迁移。Tubulin aggregation-IN-17 具有潜力进行癌症疾病的研究。
T61482	Tubulin polymerization-IN-13
	Tubulin polymerization-IN-13 (Compound 4f) is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.37 μM. It displays significant anti-proliferative effects against cancer cells, inducing apoptosis and exhibiting potential antivascular activity [1].
T60735	Tubulin polymerization-IN-22
	Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期，并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。
T79532	Tubulin polymerization-IN-44
	Tubulin polymerization-IN-44 (7w)为具高效性的微管蛋白聚合抑制剂，其IC50为0.21 μM。该化合物可诱发G2/M期阻塞并触发癌细胞凋亡(apoptosis)，适用于肿瘤研究。
T62040	Tubulin polymerization-IN-30
	Tubulin polymerization-IN-30 (compound 6e) 是有效的微管蛋白聚合 (Tubulin polymerization) 抑制剂，可破坏细胞内微管组织，将细胞周期阻滞在 G2/M 期。Tubulin polymerization-IN-30 对 HeLa、SGC-7901和A549 等肿瘤细胞系具有良好的抗肿瘤活性，其IC50分别为 0.403、 2.16和2.21 μM。
T61940	Tubulin polymerization-IN-4
	Tubulin polymerization-IN-4 是有效的微管蛋白聚合体 (tubulin polymerization) 抑制剂（IC50=4.6 μM）。Tubulin polymerization-IN-4 可以破坏微管蛋白聚合，将细胞周期阻滞在G2/M 期，诱导细胞凋亡 (apoptosis)，抑制细胞的克隆发生和迁移。Tubulin polymerization-IN-4还可以破坏血管系统。
T60936	Tubulin polymerization-IN-24
	Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的微管蛋白聚合抑制剂，可提高 GTP 水解速率并抑制微管组装。Tubulin aggregation-IN-24 诱导细胞凋亡和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 抑制乳腺癌细胞 MCF-7 的增殖。
T61069	Tubulin polymerization-IN-15
	Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].
T79645	Tubulin polymerization-IN-48
	Tubulin polymerization-IN-48 (Compound 4k) 是一种中等强度破坏微管网络的微管蛋白聚合抑制剂。其对神经母细胞瘤癌细胞增殖的抑制效果显著，Chp-134 细胞系和 Kelly 细胞系的IC50值分别为79 nM和165 nM。
T79429	Tubulin polymerization-IN-50
	Tubulin polymerization-IN-50（compound 7n）是一种Tubulin polymerization抑制剂，其在SK-Mel-28细胞中的IC50值为5.05 μM，能够诱导(cell cycle)阻滞在G2/M期。
T80922	Tubulin polymerization-IN-56
	Tubulin polymerization-IN-56（compound 8l），一种吲唑衍生的微管蛋白聚合抑制剂，通过与秋水仙碱位点的相互作用，能够引发细胞周期停滞与细胞凋亡。该化合物还能降低细胞迁移并在体内更有效地抑制肿瘤生长。
T60758	Tubulin polymerization-IN-36
	Tubulin polymerization-IN-36 可用于癌症研究，例如淋巴癌。Tubulin polymerization-IN-36 结合微管蛋白的秋水仙碱位点并且抑制秋水碱结合，是一种微管蛋白聚合的抑制剂，IC50值为 2.8 μM。
T40311	Sucrose-epichlorohydrin copolymer Sucrose-epichlorohydrin copolymer,Polysucrose 400
	Sucrose-epichlorohydrin copolymer primarily serves as a macromolecular crowder facilitating protein liquid-liquid phase separation (LLPS).
T61129	Tubulin polymerization-IN-27
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1].
T62477	Tubulin polymerization-IN-18
	Tubulin aggregation-IN-18 (compound 3) 是一种有效的 tubulin 聚合抑制剂，具有潜力进行乳腺癌和耐药结肠癌的研究。
T72169	Tubulin polymerization-IN-40
	Tubulin polymerization-IN-40为基于吖啶的微管蛋白聚合抑制剂，IC50值为1.5 μM，能在G2/M期阻滞癌细胞并诱导细胞凋亡，同时显示出抗癌活性与免疫增强作用。
T62217	Tubulin polymerization-IN-9
	Tubulin polymerization-IN-9 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 1.82 μM)。Tubulin polymerization-IN-9 能够将 K562 细胞的细胞周期停滞在 G2/M 期，并诱导其凋亡 (apoptosis) 及线粒体去极化。Tubulin polymerization-IN-9 表现出强大的抗血管和抗肿瘤作用。
T63611	Tubulin polymerization-IN-32
	Tubulin polymerization-IN-32 是微管蛋白 (tubulin) 聚合抑制剂，能够抑制癌细胞增殖，可用于研究淋巴瘤等癌症。
T63725	Tubulin polymerization-IN-35
	Tubulin polymerization-IN-35 是 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂，能够高度选择性作用于边缘区淋巴瘤 VL51 细胞系。

化合物

Mp-polymer ester

Cat.No: T18365

Target: Others

Cat.No: T20188

Synonym: Formaldehyde, urea polymer,Gabrite,Hygromull,HSDB 7203

Cat.No: T7022

Synonym: 聚乙二醇,Polyethylene glycol 300

Target: Others

Tubulin polymerization-IN-47

Cat.No: T77651

Target: Microtubule Associated

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

DNA polymerase-IN-1

Cat.No: T80644

Target: Antiviral, DNA/RNA Synthesis

Tubulin polymerization-IN-43

Cat.No: T77647

Target: Apoptosis, Microtubule Associated

RNA polymerase II-IN-1

Cat.No: T74630

Target: DNA/RNA Synthesis

Tubulin polymerization-IN-3

Cat.No: T62121

DNA polymerase-IN-4

Cat.No: T82536

Viral polymerase-IN-1 hydrochloride

Cat.No: T74765

Tubulin polymerization-IN-49

Cat.No: T79887

Taq DNA polymerase

Cat.No: T79922

Target: DNA/RNA Synthesis

Tubulin polymerization-IN-37

Cat.No: T61084

Tubulin polymerization-IN-19

Cat.No: T62206

Tubulin polymerization-IN-7

Cat.No: T63836

Tubulin polymerization-IN-16

Cat.No: T62971

Tubulin polymerization-IN-20

Cat.No: T62498

Tubulin polymerization-IN-10

Cat.No: T61600

Tubulin polymerization-IN-33

Cat.No: T63111

Tubulin polymerization-IN-53

Cat.No: T80923

Tubulin polymerization-IN-42

Cat.No: T79268

Tubulin polymerization-IN-2

Cat.No: T60802

DNA polymerase-IN-3

Cat.No: T79308

Target: DNA/RNA Synthesis

Tubulin polymerization-IN-52

Cat.No: T79766

Tubulin polymerization-IN-25

Cat.No: T62135

Tubulin polymerization-IN-21

Cat.No: T63580

Tubulin polymerization-IN-8

Cat.No: T62349

Tubulin polymerization-IN-6

Cat.No: T61532

Tubulin polymerization-IN-31

Cat.No: T60902

Tubulin polymerization-IN-34

Cat.No: T63849

Tubulin polymerization-IN-17

Cat.No: T62369

Tubulin polymerization-IN-13

Cat.No: T61482

Tubulin polymerization-IN-22

Cat.No: T60735

Tubulin polymerization-IN-44

Cat.No: T79532

Tubulin polymerization-IN-30

Cat.No: T62040

Tubulin polymerization-IN-4

Cat.No: T61940

Tubulin polymerization-IN-24

Cat.No: T60936

Tubulin polymerization-IN-15

Cat.No: T61069

Tubulin polymerization-IN-48

Cat.No: T79645

Tubulin polymerization-IN-50

Cat.No: T79429

Tubulin polymerization-IN-56

Cat.No: T80922

Tubulin polymerization-IN-36

Cat.No: T60758

Sucrose-epichlorohydrin copolymer

Cat.No: T40311

Synonym: Sucrose-epichlorohydrin copolymer,Polysucrose 400

Tubulin polymerization-IN-27

Cat.No: T61129

Tubulin polymerization-IN-18

Cat.No: T62477

Tubulin polymerization-IN-40

Cat.No: T72169

Tubulin polymerization-IN-9

Cat.No: T62217

Tubulin polymerization-IN-32

Cat.No: T63611

Tubulin polymerization-IN-35

Cat.No: T63725

Cat. No.	Product Name	Target	Signaling Pathways
T78490	Polygalacturonic acid Galacturonic acid polymer
	Polygalacturonic acid（Galacturonic acid polymer）为透明胶状物，构成细胞壁关键组分。该酸应用于制备银纳米颗粒（AgNPs），充当抗氧化剂与抗炎剂，防护细胞遭受ROS增高引起的损伤，并促进伤口愈合。Polygalacturonic acid纳米颗粒亦显示抗菌性能。
T31337	Decanedioic acid, homopolymer 1,10-decanedioic acid,Sebacic acid,EINECS 203-845-5
	Decanedioic acid, homopolymer is a biochemical.
T40646	Lipoteichoic acid	Complement System	Immunology/Inflammation
	Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的聚合物，通过诱导 C3 和抑制 CD55 来激活补体系统，通过 IGF-1 途径减少脂肪沉积。
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T7916	4-Acetamidobenzenesulfonyl azide	Others	Others
	4-Acetamidobenzenesulfonyl azide 用于各种科学研究应用，包括药物、肽和其他生物活性分子的合成，也被用作聚合反应和聚合物合成中的催化剂。
T11849	Lignin 木质素,脱碱的,木质素,Lignine	Others	Others
	Lignin (Lignine) 是一种具有生物可降解性和生物相容性的天然复合生物聚合物。它是植物细胞壁的主要成分，是一种可再生的芳香族聚合物，具有显著的抗氧化作用。
T7962	Coumalic acid 香豆酸,Cumalic Acid	Others	Others
	Coumalic acid (Cumalic Acid) 可以由苹果酸制备。它可用于香料、调味剂及化妆品工业生产中。它作为聚合物组分以及具有抗支气管和疟疾活性的活性分子支架。
T75639	Cellohexaose
	Cellohexaose，一种由β(1-4)链接的D-葡萄糖单体通过缩合反应形成的葡萄糖聚合物，来源于纤维素的分解，包含两个或更多的葡萄糖单体。
T21101	1-Decanol 1-Hydroxydecane,Caprinic alcohol,Decyl alcohol,Decanol,n-Decanol,Alcohol C-10
	1-Decanol is used in the production of lubricants, surfactants, plasticizers, and solvents. It is also used to study the thermal properties of polymer-monolithic stationary phases and is used to enhance the homomeric glycine receptor function. It is used
T38499	κ-Carrageenan
	κ-Carrageenan, a natural polymer found predominantly in red seaweeds, can serve as an effective drug carrier for delivering curcumin to cancer cells and inducing apoptosis. Additionally, κ-Carrageenan holds promise as a potential inflammatory agent, amplifying existing intestinal inflammation.
T20612	4,5,6,7-Tetrachlorophthalide KF 32,KF32,Rabcide,KF-32,Fthalide
	4,5,6,7-Tetrachlorophthalide is a fungicide used for the control of rice blast. It has a role as a melanin synthesis inhibitor and an antifungal agrochemical.

天然产物

Polygalacturonic acid

Cat.No: T78490

Synonym: Galacturonic acid polymer

Decanedioic acid, homopolymer

Cat.No: T31337

Synonym: 1,10-decanedioic acid,Sebacic acid,EINECS 203-845-5

Lipoteichoic acid

Cat.No: T40646

Target: Complement System

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

4-Acetamidobenzenesulfonyl azide

Cat.No: T7916

Target: Others

Cat.No: T11849

Synonym: 木质素,脱碱的,木质素,Lignine

Target: Others

Cat.No: T7962

Synonym: 香豆酸,Cumalic Acid

Target: Others

Cat.No: T75639

Cat.No: T21101

Synonym: 1-Hydroxydecane,Caprinic alcohol,Decyl alcohol,Decanol,n-Decanol,Alcohol C-10

Cat.No: T38499

4,5,6,7-Tetrachlorophthalide

Cat.No: T20612

Synonym: KF 32,KF32,Rabcide,KF-32,Fthalide

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