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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6609	NMS-E973	HSP	Cytoskeletal Signaling; Metabolism
	NMS-E973 是一种有效且选择性的 Hsp90 抑制剂，与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障，具有抗肿瘤效果。
T6788	Bitopertin Paliflutine,比拓喷丁,RO4917838,RG1678,比托派汀	GlyT	Neuroscience
	Bitopertin (Paliflutine) 是一种有效的甘氨酸转运蛋白 1 (GlyT1) 抑制剂，对人 hGlyT1b 的 Ki 为 8.1 nM。
T22641	CDPPB	GluR	Neuroscience
	CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
T9916	Alirocumab	Others	Others
	Alirocumab 是 PCSK9的人单克隆抗体。它能够特异性结合肝脏低密度脂蛋白 (LDL) 受体的下调剂 PCSK9，增强肝脏结合 LDL-胆固醇 (LDL-C) 的能力，降低血液中的 LDL-C 水平。它可用于研究高胆固醇血症。
T12970	Solabegron GW 427353,3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Solabegron (GW 427353) 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得 EC50=22 nM，可用于研究膀胱过度活跃和肠易激综合征。
T50086	Clomesone	Others	Others
	Clomesone 是一种合成的非甾体药物，可用作分子结构单元。它是一种常用于治疗女性不孕的药物，通过阻断大脑中雌激素的作用发挥作用，已被证明对患有多囊卵巢综合征和其他不孕问题的女性有效诱导排卵。
T23549	YM 511	P450; Aromatase	Endocrinology/Hormones; Metabolism
	YM 511 是一种高度特异性的非甾体芳香酶 (aromatase) 抑制剂。YM 511 竞争性抑制大鼠卵巢和人胎盘微粒体中的芳香酶活性 (IC50 分别为 0.4 和 0.12 nM)。YM 511 轻微抑制其他类固醇激素的产生。YM 511 具有用于抑制雌激素依赖性作用研究，不会影响其他类固醇激素的血清水平的潜力。
TP1425	Motilin (26-47), human, porcine 胃动素 (人类，猪)	Motilin Receptor	GPCR/G Protein
	Motilin (26-47), human, porcine 是内源性 motilin 受体的激动剂，在中国仓鼠卵巢细胞中，Ki 值和EC50值分别为 2.3 和 0.3 nM。
T80602	Dovanvetmab ZTS-00521505
	Dovanvetmab (ZTS-00521505)，一种IgG1-κ型抗体，专一性靶向Felcat IL31，由CHO（Chinese Hamster Ovary）细胞主要表达。
T33411	Mitopodozide SP-I 77,SPI 77,SPI-77
	Mitopodozide, as an ethylhydrazide derivative of podophyllic acid, acts as a mitotic poison in carcinomas of the ovary.
T82511	Ebdarokimab
	Ebdarokimab (AK101)，一种人源化IgG1-κ抗体，其表达系统主要选用CHO（中国仓鼠卵巢）细胞。
T82507	Ecleralimab CSJ-117,NVP-CSJ117
	Ecleralimab (CSJ-117; NVP-CSJ117) 是一种 Fab-IgG1-λ2 类型的单克隆抗体，专一性靶向胸腺基质淋巴生成素（TSLP）。该抗体主要采用 CHO（Chinese Hamster Ovary）细胞表达系统生产。
T71904	Chlormadinone (free base)
	Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
T80596	Coprelotamab GB-221	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Coprelotamab (GB-221) 为针对EGFR2的IgG-κ类单克隆抗体。该化合物通常在CHO DG44 (中国仓鼠卵巢) 细胞中表达。
T80611	Sasanlimab PF-06801591	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sasanlimab（PF-06801591），一种人源化IgG4-κ抗PD-1抗体，由CHO（中国仓鼠卵巢）细胞主要表达。
T80603	Dresbuxelimab AK-119	CD73	Immunology/Inflammation
	Dresbuxelimab (AK-119) 为靶向CD73的IgG-κ型单克隆抗体，常用CHO（中国仓鼠卵巢）细胞作为表达系统。
T64298	Turoctocog alfa
	Turoctocog alfa 是一种来源于中国仓鼠卵巢 (CHO) 细胞的重组凝血因子 VIII (FVIII)。Turoctocog alfa 能够用于研究 A 型血友病。
T82696	Cofetuzumab PF-06523435,hu24
	Cofetuzumab (PF-06523435)为针对PTK7的人源化IgG1-κ亚型单克隆抗体，常在CHO（中国仓鼠卵巢）细胞表达体系中生产。
T80614	Serclutamab DC-1630423,PR-1594407	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Serclutamab是一种针对EGFR的IgG1-κ型人源化嵌合抗体，主要通过CHO（中国仓鼠卵巢）细胞进行表达。
T26770	Bencycloquidium Bromide BCQB
	Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M
T80608	Ebronucimab AK102
	Ebronucimab (AK102)为一种针对PCSK9的IgG1-λ2单克隆抗体，其主要源自经过工程化改造的CHO DG44细胞系。
T71908	NU1085
	NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h.
T80499	Jingzhaotoxin XI JZTX-XI	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin XI (JZTX-XI) 为抑制钠电导的化合物，其IC50值为124 nM。该化合物能够减缓CHO-K1细胞中Nav1.5通道的快速失活，EC50值为1.18±0.2 μM。
T71483	Streptonigrin (racemate)
	Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.
T80598	Davoceticept CD80 vIgD-Fc,ALPN-202
	Davoceticept (ALPN-202; CD80 vIgD-Fc) 是一种靶向CTLA-4的单克隆抗体。它包含CD80的(1-107)片段，该片段通过肽基连接子与IGHG1 Fc连接。Davoceticept通常在CHO（中国仓鼠卵巢）细胞中表达。
T82501	Efavaleukin alfa AMG592
	Efavaleukin alfa (AMG592) 是一种人源化的单克隆抗体，由 IGHG1 Fc 片段与 IL-2 融合构成。其表达体系一般采用 CHO (中国仓鼠卵巢) 细胞。
T60990	U92016A hydrochloride
	U92016A hydrochloride 是口服有效的5-HT1A 受体激动剂，代谢稳定。U92016A hydrochloride 表现出极高的内在活性，能够以高亲和力结合中国仓鼠卵巢细胞中表达的人 5-HT1A 受体，Ki 值为0.2 nM。
T27647	J-104132 L753037,L 753037,J104132,J 104132,L-753037
	J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ova
T36672	CAY10561
	The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561...
T69056	Albizziin
	Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagin...
T37594	Pericosine A
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...
T10106	3-arylisoquinolinamine derivative	Others	Others
	3-arylisoquinolinamine derivative is a compound with antitumor activity.

化合物

Cat.No: T6609

Target: HSP

Cat.No: T6788

Synonym: Paliflutine,比拓喷丁,RO4917838,RG1678,比托派汀

Target: GlyT

Cat.No: T22641

Target: GluR

Cat.No: T9916

Target: Others

Cat.No: T12970

Synonym: GW 427353,3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸

Target: Adrenergic Receptor

Cat.No: T50086

Target: Others

Cat.No: T23549

Target: P450, Aromatase

Motilin (26-47), human, porcine

Cat.No: TP1425

Synonym: 胃动素 (人类，猪)

Target: Motilin Receptor

Cat.No: T80602

Synonym: ZTS-00521505

Cat.No: T33411

Synonym: SP-I 77,SPI 77,SPI-77

Cat.No: T82511

Cat.No: T82507

Synonym: CSJ-117,NVP-CSJ117

Chlormadinone (free base)

Cat.No: T71904

Cat.No: T80596

Synonym: GB-221

Target: EGFR

Cat.No: T80611

Synonym: PF-06801591

Target: PD-1/PD-L1

Cat.No: T80603

Synonym: AK-119

Target: CD73

Turoctocog alfa

Cat.No: T64298

Cat.No: T82696

Synonym: PF-06523435,hu24

Cat.No: T80614

Synonym: DC-1630423,PR-1594407

Target: EGFR

Bencycloquidium Bromide

Cat.No: T26770

Synonym: BCQB

Cat.No: T80608

Synonym: AK102

Cat.No: T71908

Jingzhaotoxin XI

Cat.No: T80499

Synonym: JZTX-XI

Target: Sodium Channel

Streptonigrin (racemate)

Cat.No: T71483

Cat.No: T80598

Synonym: CD80 vIgD-Fc,ALPN-202

Efavaleukin alfa

Cat.No: T82501

Synonym: AMG592

U92016A hydrochloride

Cat.No: T60990

Cat.No: T27647

Synonym: L753037,L 753037,J104132,J 104132,L-753037

Cat.No: T36672

Cat.No: T69056

Cat.No: T37594

3-arylisoquinolinamine derivative

Cat.No: T10106

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。

天然产物

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

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