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33

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6550	Isoconazole nitrate 硝酸异康唑,Travogyn,Fazol	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Isoconazole nitrate (Fazol) 是一种唑类抗真菌试剂。它具有强效的抗真菌和革兰氏阳性菌的活性，以及快速吸收和系统性暴露低的特点。
T6499	Fenticonazole Nitrate REC 15-1476,硝酸芬替康唑,Falvin,Lomexin	Antibiotic; Antifungal	Microbiology/Virology
	Fenticonazole Nitrate (Lomexin) 是一种抗真菌的咪唑环衍生物。它阻止麦角固醇整合和依次破坏细胞质外膜起作用。它对革兰氏阳性菌，真菌病和阴道念珠菌病有效。
T0444L	Econazole nitrate NSC 243115,硝酸益康唑	Antibacterial; Antibiotic; Antifection; Antifungal	Microbiology/Virology
	Econazole nitrate (NSC-243115) 是一种有抗菌活性的咪唑类抗真菌药物。
T1438	Butoconazole nitrate RS 35887,硝酸布康唑	Estrogen/progestogen Receptor; Antifungal	Endocrinology/Hormones; Microbiology/Virology
	Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。
T7824	Eberconazole Nitrate 硝酸依柏康唑,Ebernet	Antifungal	Microbiology/Virology
	Eberconazole Nitrate (Ebernet) 是一种二氯咪唑衍生物，具有抗真菌活性，效果比Ketoconazole、Clotrimazole 和Miconazole 强。它通过局部给药对皮肤癣菌病具有潜在的研究价值。
T1290	Oxiconazole nitrate 硝酸奥昔康唑,Ro 13-8996	Others; Antibiotic; Antifection; Antifungal	Microbiology/Virology; Others
	Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg/mL。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T30750	Carnosine nitrate (+)-Carnosine nitrate
	Carnosine nitrate is a dipeptide molecule. It is highly concentrated in muscle and brain tissues.
T10915	Cycloguanil D6 Nitrate Chlorguanide triazine D6 Nitrate	Others	Others
	Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.
T36204	Methylatropine (nitrate)
	Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotin...
T69055	PD153035 nitrate
	PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T69593	Sildenafil nitrate
	Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T6686	Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病，花斑糠疹病，皮肤念珠菌病。
T32097	Homoanserine Nitrate
	Homoanserine Nitrate is a dipeptide found in mammalian brains and muscles.
T10562	(4-Acetamidocyclohexyl) nitrate BM121307	Others	Others
	(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase.
T0446L	Naphazoline nitrate Benil,Sanorin Spofa,Rhinon,Rinazina,Clera
	Naphazoline nitrate is an α1-Adrenergic receptor agonist. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation. It used to treat congestion and ocular pathologies.
T17378	Ald-Ph-amido-C2-nitrate	Others	Others
	Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative primarily employed as a noncleavable ADC linker[1].
T69591	Cycloguanil nitrate
	Cycloguanil nitrate is a dihydrofolate reductase inhibitor and is a metabolite of the antimalarial drug proguanil.
T124812	Sanguinarine nitrate
	Sanguinarine nitrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124812。
T60425	Tetrahydrozoline nitrate
	Tetrahydrozoline (Tetryzoline) nitrate 是咪唑啉的衍生物。它是一种引起血管收缩的α-肾上腺素能 (α-adrenergic) 激动剂。Tetrahydrozoline 广泛用于鼻充血和结膜充血的研究。
T125540	Sempervirine nitrate
	Sempervirine nitrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125540。
T28742	Securinine mononitrate Securinan-11-one nitrate
	Securinine mononitrate is a cholinergic agent and an antagonist of gamma-aminobutyric acid A (GABAA) receptor.
T31977	GLYN NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875
	GLYN, a nitric oxide donor, acts by enhancing the therapeutic efficacy of chemotherapy and radiotherapy.
T33595	Naproxcinod AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582
	Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a
T66321	Ethyl 3-guanidino-4-methylbenzoate nitrate
	Ethyl 3-guanidino-4-methylbenzoate nitrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66321，CAS号为 641569-96-2。
T21700	NOS-IN-1 2-Imino-4-methylpiperidine (acetate)	NOS	Immunology/Inflammation
	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) 是有效的、具有口服活性的一氧化氮合酶 (NOS) 的抑制剂。NOS-IN-1抑制人 iNOS (hiNOS)，hnNOS 和 heNOS 的 IC50 分别为 0.1 μM，0.2 μM 和1.1 μM。
T6863	Isosorbide Mononitrate 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan	Others; Autophagy	Autophagy; Others
	Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂，扩张血管从而降低血压，可用于心绞痛。
T31671	Erythrityl Tetranitrate Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle
	Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin. Like many nitrate esters, ETN acts as a vasodilator, and was the active ingredient in the original "sustained release" tablets, made in the early 50s. Ingesting ETN or prolonged skin contact can lead to absorption and what is known as a "nitro headache".
T32209	Isoidide mononitrate L-Iimn,L-Isoidide-2-mononitrate
	Isoidide mononitrate is a potent mononitrate vasodilator.
T24786	SG-209
	SG 209是nicorandil的类似物，可作为K+通道开放剂和无硝酸盐的冠状血管扩张剂。
T35996	FeTPPS
	Peroxynitrite is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.[1] FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomerization to produce nitrate both in vitro and in vivo. The conversion of this reactive nitrogen species to nitrate results in cytoprotection (EC50 = 5 &#181M). [2][3] FeTPPS does not complex with NO and does not alter superoxide directly. It is commonly used to elucidate the roles...
T36203	Menaquinone 9 MK-9,Vitamin K2(45),Menaquinone 9
	Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.

化合物

Isoconazole nitrate

Cat.No: T6550

Synonym: 硝酸异康唑,Travogyn,Fazol

Target: Antibacterial, Antibiotic, Antifungal

Fenticonazole Nitrate

Cat.No: T6499

Synonym: REC 15-1476,硝酸芬替康唑,Falvin,Lomexin

Target: Antibiotic, Antifungal

Econazole nitrate

Cat.No: T0444L

Synonym: NSC 243115,硝酸益康唑

Target: Antibacterial, Antibiotic, Antifection, Antifungal

Butoconazole nitrate

Cat.No: T1438

Synonym: RS 35887,硝酸布康唑

Target: Estrogen/progestogen Receptor, Antifungal

Eberconazole Nitrate

Cat.No: T7824

Synonym: 硝酸依柏康唑,Ebernet

Target: Antifungal

Oxiconazole nitrate

Cat.No: T1290

Synonym: 硝酸奥昔康唑,Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Carnosine nitrate

Cat.No: T30750

Synonym: (+)-Carnosine nitrate

Cycloguanil D6 Nitrate

Cat.No: T10915

Synonym: Chlorguanide triazine D6 Nitrate

Target: Others

Methylatropine (nitrate)

Cat.No: T36204

PD153035 nitrate

Cat.No: T69055

Sildenafil nitrate

Cat.No: T69593

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Sulconazole mononitrate

Cat.No: T6686

Synonym: Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑

Target: Antibacterial, Antibiotic, Antifungal

Homoanserine Nitrate

Cat.No: T32097

(4-Acetamidocyclohexyl) nitrate

Cat.No: T10562

Synonym: BM121307

Target: Others

Naphazoline nitrate

Cat.No: T0446L

Synonym: Benil,Sanorin Spofa,Rhinon,Rinazina,Clera

Ald-Ph-amido-C2-nitrate

Cat.No: T17378

Target: Others

Cycloguanil nitrate

Cat.No: T69591

Sanguinarine nitrate

Cat.No: T124812

Tetrahydrozoline nitrate

Cat.No: T60425

Sempervirine nitrate

Cat.No: T125540

Securinine mononitrate

Cat.No: T28742

Synonym: Securinan-11-one nitrate

Cat.No: T31977

Synonym: NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875

Cat.No: T33595

Synonym: AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582

Ethyl 3-guanidino-4-methylbenzoate nitrate

Cat.No: T66321

Cat.No: T21700

Synonym: 2-Imino-4-methylpiperidine (acetate)

Target: NOS

Isosorbide Mononitrate

Cat.No: T6863

Synonym: 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan

Target: Others, Autophagy

Erythrityl Tetranitrate

Cat.No: T31671

Synonym: Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle

Isoidide mononitrate

Cat.No: T32209

Synonym: L-Iimn,L-Isoidide-2-mononitrate

Cat.No: T24786

Cat.No: T35996

Cat.No: T36203

Synonym: MK-9,Vitamin K2(45),Menaquinone 9

Cat. No.	Product Name	Target	Signaling Pathways
T0344L	Miconazole nitrate NSC 169434 Nitrate,硝酸咪康唑,R18134 nitrate	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Miconazole nitrate (R18134 nitrate) 是咪唑类可抗菌的抗真菌剂。
T13923	Thiamine nitrate 硝酸硫胺,Vitamin B1 nitrate	Others	Others
	Thiamine nitrate (Vitamin B1 nitrate) 是必不能够少的维生素，能够提高正常的神经元活性。
T4704	L-Anserine nitrate L-鹅肌肽硝酸盐,L-Anserine nitrate salt	Others; Endogenous Metabolite	Metabolism; Others
	L-Anserine nitrate (L-Anserine nitrate salt) 是一种存在于大多数动物组织中的二肽。在模型系统中，它是一种有效的抗氧化剂和羟基自由基清除剂。该化合物抑制醛糖和酮糖还原糖诱导的非酶蛋白糖基化。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T1231	Pilocarpine nitrate 匹鲁卡品硝酸盐,Pilagan,硝酸毛果芸香碱,Pilofrin	AChR	Neuroscience
	Pilocarpine nitrate (Pilagan) 是 M3 型毒蕈碱乙酰胆碱受体激动剂，可用于治疗青光眼。
TN1003	DL-Alanine DL-2-Aminopropionic acid	Endogenous Metabolite	Metabolism
	DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸，是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂，可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。

天然产物

Miconazole nitrate

Cat.No: T0344L

Synonym: NSC 169434 Nitrate,硝酸咪康唑,R18134 nitrate

Target: Antibacterial, Antibiotic, Antifungal

Thiamine nitrate

Cat.No: T13923

Synonym: 硝酸硫胺,Vitamin B1 nitrate

Target: Others

L-Anserine nitrate

Cat.No: T4704

Synonym: L-鹅肌肽硝酸盐,L-Anserine nitrate salt

Target: Others, Endogenous Metabolite

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Pilocarpine nitrate

Cat.No: T1231

Synonym: 匹鲁卡品硝酸盐,Pilagan,硝酸毛果芸香碱,Pilofrin

Target: AChR

Cat.No: TN1003

Synonym: DL-2-Aminopropionic acid

Target: Endogenous Metabolite

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