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Search Results for " myocardial-protective "

3

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9180	LUF6096 CF-602	Adenosine Receptor	GPCR/G Protein; Neuroscience
	LUF6096 (CF-602) 是一种有效的腺苷 A3 受体 (adenosine A3 receptor) 变构增强剂。LUF6096 对任何腺苷受体显示出低正构亲和力。LUF6096 在心肌缺血/再灌注损伤中显示出保护作用。
T68878	L-2286
	L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.
T72281	Caspase-9 Inhibitor III Ac-LEHD-cmk
	Caspase-9 Inhibitor III (Ac-LEHD-cmk) 是一种 caspase-9抑制剂。Caspase-9 Inhibitor III 对局部缺血-重新灌注诱导的心肌损伤表现出保护作用。

化合物

Cat.No: T9180

Synonym: CF-602

Target: Adenosine Receptor

Cat.No: T68878

Caspase-9 Inhibitor III

Cat.No: T72281

Synonym: Ac-LEHD-cmk

Cat. No.	Product Name	Target	Signaling Pathways
T8158	Tilianin 香清兰苷,田蓟苷	Others	Others
	Tilianin 是一种广泛存在于多种药用植物中的活性黄酮类苷，具有降压、保护心肌、降血脂、抗糖尿病、抗炎、抗氧化等作用。
T3S0289	Araloside X	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
T2S0500	Ilexsaponin A 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1	Others	Others
	Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中，利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小，减少 LDH，AST 和 CK-MB 的血清水平，促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。
T3920	Pseudoginsenoside F11 Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11	Others; Endogenous Metabolite	Metabolism; Others
	Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。
T2973	Astragaloside IV AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV	MMP; ERK; Estrogen/progestogen Receptor; JNK	Endocrinology/Hormones; MAPK; Proteases/Proteasome
	Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷，抑制ERK1/2和JNK 激活，在乳腺癌细胞 MDA-MB-231 中，下调(MMP)-2和(MMP)-9的信号通路。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T4S0280	Eleutheroside D
	Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
TN3914	Echinatine	ATPase; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil

天然产物

Cat.No: T8158

Synonym: 香清兰苷,田蓟苷

Target: Others

Cat.No: T3S0289

Target: Calcium Channel

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Cat.No: T2S0500

Synonym: 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1

Target: Others

Pseudoginsenoside F11

Cat.No: T3920

Synonym: Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11

Target: Others, Endogenous Metabolite

Astragaloside IV

Cat.No: T2973

Synonym: AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Eleutheroside D

Cat.No: T4S0280

Cat.No: TN3914

Target: ATPase, IL Receptor, TNF

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