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24

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21980	PD 198306	MEK	MAPK
	PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。
T2208	Bacitracin Zinc 杆菌肽锌,Bacitracin zinc salt,Zinc bacitracin	c-Met/HGFR; Antibacterial; Antibiotic	Microbiology/Virology; Tyrosine Kinase/Adaptors
	Bacitracin Zinc 是 C55-异戊二烯焦磷酸酯的去磷酸化干扰物，可抑制 Met-enkephalin 中 Tyr 的裂解，IC50为10 μM。
T1386	Phenazopyridine hydrochloride Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶	Sodium Channel	Membrane transporter/Ion channel
	Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质，常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
T39802	Nedosiran DCR-PHXC
	Nedosiran (DCR-PHXC) is a GalNAc-dsRNA conjugate designed for RNA interference (RNAi) targeting lactate dehydrogenase (LDH). It serves as a potential therapeutic option for patients with primary hyperoxaluria (PH) and end-stage renal disease (ESRD).
T71129	AZD6564
	AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-protein interaction.
T33755	NSC57971
	NSC57971 is a novel non-peptide interference of the IKKß/NEMO complex.
T69089	Trimethoprim sulfate
	Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
T39487	HaXS8
	HaXS8 is a dimerizer that facilitates the covalent and irreversible intracellular dimerization of proteins of interest labeled with HaloTag and SNAP-tag. Furthermore, HaXS8 does not exhibit any interference with PI3K/mTOR signaling.
T40259	AB-729
	AB-729, a nucleoside analogue functioning as an RNA interference (RNAi), links to a GalNAc (N-acetylgalactosamine) trimer ligand facilitating hepatocyte uptake through the asialoglycoprotein receptor (ASGR). This compound effectively impedes viral replication and diminishes HBV antigens.
T39274	Lumasiran sodium
	Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, targets glycolate oxidase to reduce hepatic oxalate production, thereby reducing urinary oxalate excretion. This compound shows promise in addressing the underlying cause of progressive kidney failure in individuals with primary hyperoxaluria type 1 (PH1).
T61284	Antibacterial agent 94
	Antibacterial agent 94 (compound 5b) is a highly effective antibacterial agent that demonstrates strong activity against various bacterial strains. Notably, Antibacterial Agent 94 is capable of eradicating MRSA persisters, highlighting its potential as a therapeutic solution. Its mechanism of action involves interference with the bacterial membrane and disruption of the phosphatidylglycerol (PG) synthesis pathway [1].
T38326	Cromolyn (sodium salt hydrate)
	Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.
T78429	QTZ
	QTZ为腔肠素类似的生物发光剂，在活体成像中应用，其发射光具红移特性，且能确保较低的成像背景。
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran（终端糖基修饰）是一种靶向C5 mRNA的siRNA，通过N-乙酰半乳糖胺缀合增强RNAi活性，能够抑制肝脏中补体成分C5的生成。
T35924	Tat-NR2Baa Tat-NR2Baa
	Tat-NR2BAA is an inactive control peptide of Tat-NR2B9c. It shares a similar sequence with Tat-NR2B9c, but possesses a double-point mutation in the COOH terminal tSXV motif. This mutation renders Tat-NR2BAA unable to bind PSD-95. Tat-NR2B9c, on the other hand, is a membrane-permeable peptide that interferes with PSD-95/NMDAR binding. This interference leads to the decoupling of NR2B- and/or NR2A-type NMDARs from PSD-95[1][2].
T62527	INO-1001
	INO-1001 是一种有效的、选择性聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有抗肿瘤活性。INO-1001 是一种有效的辐射敏感性增强剂，能够利用干扰 DNA 修复机制，进而提高辐射诱导的细胞杀伤，使坏死细胞死亡。
T38076	ThioGlo1 ThioGlo1
	ThioGlo1 is a thiol-reactive fluorescent probe.1,2,3Upon reaction with a thiol group, a fluorescent adduct is formed that displays excitation/emission maxima of 384/513 nm, respectively.2,3It also reacts with sulfite to form a fluorescent adduct with similar spectral characteristics, and interference from sulfite during thiol determination must be accounted for using secondary methods. ThioGlo1 has been used to monitor the oxidative stability of beer. 1.Yang, J.-R., and Langmuir, M.E.Synthesis a...
T26452	A 80b A80b,A-80b
	A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-8
T76021	Myelin Basic Protein TFA
	Myelin Basic Protein (MHP4-14) TFA 是一种合成肽，包含髓鞘碱性蛋白的残基4-14，是一种非常有选择性的 PKC 底物 (Km=7 μM)。Myelin Basic Protein TFA 不被环腺苷酸依赖性蛋白激酶、酪蛋白激酶 I 和 II、Ca2+/钙调素依赖性蛋白激酶 II 或磷酸化酶激酶磷酸化，可常规用于测定粗组织提取物中低背景的蛋白激酶 C。
T82771	CB2-H
	CB2-H为一种高特异性双通道荧光探针，专门设计用于HOCl和ONOO-的同时检测。该探针在两个分离的通道中对HOCl和ONOO-无交叉干扰的检测能力使其适用于对活细胞和斑马鱼样本内HOCl及ONOO-的内源性水平进行双通道荧光成像分析，即使在不同生物刺激下也能保持准确性。
T41171	BODIPY FL VH032
	BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL(with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable...
T37762	Fura-FF AM
	Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 . Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation. Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively). ...
T37761	Fura-FF (potassium salt)
	Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.[1] Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively).[1],[2]However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presen...
T83664	Europium W1024 ITC Eu-W1024 ITC,Europium W1024 Isothiocyanate
	Europium W1024 isothiocyanate (ITC) 是一种基于镧系元素的荧光团，具有长发射寿命和大的斯托克斯位移。其激发/发射峰值分别为340/613 nm。Europium W1024 ITC含有一个反应性的异硫氰酸酯基团，能在碱性pH条件下与初级氨基发生反应。在高温、高EDTA浓度或低pH环境下稳定，但在锰的存在下不稳定。Europium W1024 ITC通常被连接到各种分子上，并作为TR-FRET中的供体荧光团使用，其长发射寿命为受体荧光的测量提供了更长的时间窗口，减少了自发荧光的干扰。

化合物

Cat.No: T21980

Target: MEK

Bacitracin Zinc

Cat.No: T2208

Synonym: 杆菌肽锌,Bacitracin zinc salt,Zinc bacitracin

Target: c-Met/HGFR, Antibacterial, Antibiotic

Phenazopyridine hydrochloride

Cat.No: T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Target: Sodium Channel

Cat.No: T39802

Synonym: DCR-PHXC

Cat.No: T71129

Cat.No: T33755

Trimethoprim sulfate

Cat.No: T69089

Cat.No: T39487

Cat.No: T40259

Lumasiran sodium

Cat.No: T39274

Antibacterial agent 94

Cat.No: T61284

Cromolyn (sodium salt hydrate)

Cat.No: T38326

Cat.No: T78429

Cemdisiran, terminal sugar modification-

Cat.No: T74550

Cat.No: T35924

Synonym: Tat-NR2Baa

Cat.No: T62527

Cat.No: T38076

Synonym: ThioGlo1

Cat.No: T26452

Synonym: A80b,A-80b

Myelin Basic Protein TFA

Cat.No: T76021

Cat.No: T82771

BODIPY FL VH032

Cat.No: T41171

Cat.No: T37762

Fura-FF (potassium salt)

Cat.No: T37761

Europium W1024 ITC

Cat.No: T83664

Synonym: Eu-W1024 ITC,Europium W1024 Isothiocyanate

Cat. No.	Product Name	Target	Signaling Pathways
T2911	Stevioside 甜菊苷,蛇菊苷	TLR	Immunology/Inflammation
	Stevioside 是一种天然甜味剂，从甜叶菊叶中提取的获得，具有抗癌作用。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T8678	Naphthazarin 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) 是来自毛紫草的一种天然产物，通过氧化应激、线粒体凋亡诱导因子的激活、微管的解聚、干扰溶酶体功能和 p53 依赖性 p21 激活，可触发细胞凋亡并具有抗肿瘤作用。
T2966	Beta-Sitosterol Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost	Apoptosis; Lipase; Endogenous Metabolite	Apoptosis; Metabolism
	Beta-Sitosterol (SKF 14463) 是一种植物甾醇，干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
T2S1797	Santalol 檀香醇；白檀油萜醇;檀香脑,檀香醇	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	Santalol 是一种檀香醇的 α 和 β-异构体混合物。其中α-santalol 分离自檀香油中，是一种有前途的抗癌药，能够预防口腔癌、前列腺癌、乳腺癌和皮肤癌。
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat

天然产物

Cat.No: T2911

Synonym: 甜菊苷,蛇菊苷

Target: TLR

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T8678

Synonym: 萘茜,5,8-Dihydroxy-1,4-naphthoquinone,DHNQ

Target: Apoptosis

Beta-Sitosterol

Cat.No: T2966

Synonym: Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Cat.No: T2S1797

Synonym: 檀香醇；白檀油萜醇;檀香脑,檀香醇

Target: Antioxidant, Antifungal

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

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