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6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1761L |
Handle region peptide, rat acetate
Handle region peptide, rat acetate(749227-53-0 free base) |
Others | Others |
Handle region peptide, rat acetate(749227-53-0 free base) 是一种肾素原受体拮抗剂,可抑制糖尿病肾病的进展并具有抗炎作用。 | |||
T27176 |
Dimethandrolone Undecanoate
DMAU |
Others | Others |
Dimethandrolone Undecanoate (DMAU) 是一种新型可口服的雄激素,具有孕激素活性,是有潜力的男性避孕化合物。 | |||
TP1761 |
Handle region peptide, rat
|
||
Handle region peptide, rat, functions as a prorenin receptor antagonist, effectively inhibiting the development of diabetic nephropathy while also exhibiting anti-inflammatory properties specifically within the eye. | |||
T69717 |
Dimethandrolone
|
||
Dimethandrolone (DMA), also known by its developmental code name CDB-1321, is an experimental androgen/anabolic steroid (AAS) and progestogen medication which is under investigation for potential clinical use. Dimethandrolone is an AAS, and hence is an agonist of the androgen receptor, the biological target of androgens like testosterone. It is also a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progestero... | |||
TP1909L1 |
CALP2 acetate(261969-04-4 free base)
|
CaMK; PDE | Metabolism; Neuroscience |
CALP2 acetate 是一种钙调蛋白拮抗剂,对与 CaM EF-hand/Ca2+-结合位点具有高亲和力,Kd 为 7.9 µM。它有效抑制粘附和脱粒。它也是肺泡巨噬细胞的强激活剂。它抑制 CaM 依赖性磷酸二酯酶活性并增加细胞内 Ca2+ 浓度。 | |||
TP1910L1 |
CALP1 acetate
CALP1 acetate(145224-99-3 free base) |
CaMK | Neuroscience |
CALP1 acetate 是一种钙调蛋白 (CaM) 激动剂(Kd 为 88 µM),可与 CaM EF-hand/Ca2+ 结合位点结合。 CALP1 通过抑制钙通道的开放来阻断钙流入和细胞凋亡(IC50 为 44.78 µM)。 CALP1 阻断谷氨酸受体通道并阻断储存操作的非选择性阳离子通道。 CALP1 激活依赖于 CaM 的磷酸二酯酶活性。 | |||
TP1911L |
CALP3 acetate(261969-05-5 free base)
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CALP3 acetate(261969-05-5 free base) 是一种有效的 Ca2+ 通道阻滞剂,可激活 Ca2+ 结合蛋白的 EF 手基序。 它可以通过调节钙调蛋白 (CaM)、Ca2+ 通道和泵的活性在功能上模拟增加的 [Ca2+]i。 | |||
T4313 |
Tinoridine hydrochloride
盐酸替诺立定,Nonflamin,Y-3642 hydrochloride |
COX; Glutathione Peroxidase | Immunology/Inflammation; Metabolism; Neuroscience |
Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药,具有显著的自由基清除和抗过氧化物特性。 | |||
T33627 |
Nematocyphol
|
||
Nematocyphol is a triterpenoid from Euphorbia nematocypha hand-mazz. | |||
TP2170 |
CALP3 TFA(261969-05-5 free base)
CALP3 TFA |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin, Ca2+ channels, and pumps. | |||
TP1911 |
CALP3
|
||
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM). | |||
TP1909 |
CALP2
|
||
Cell-permeable calmodulin (CaM) antagonist that binds to the EF-hand/Ca2+-binding site. CALP2 has been demonstrated to inhibit CaM-dependant phosphodiesterase activity and increase intracellular Ca2+ concentrations by modulating Ca2+-channel activity. CAL | |||
T75790 |
CALP2 TFA
|
||
CALP2 TFA 是一种钙调蛋白 (CaM) 拮抗剂 (Kd 为 7.9 µM),以亲和力结合CaMEF-hand/Ca2+结合位点。CALP2 TFA 抑制CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性并增加细胞内 Ca2+浓度。CALP2 TFA 有效抑制粘附和脱粒。CALP2 TFA 还是肺泡巨噬细胞的强激活剂。 | |||
T35924 |
Tat-NR2Baa
Tat-NR2Baa |
||
Tat-NR2BAA is an inactive control peptide of Tat-NR2B9c. It shares a similar sequence with Tat-NR2B9c, but possesses a double-point mutation in the COOH terminal tSXV motif. This mutation renders Tat-NR2BAA unable to bind PSD-95. Tat-NR2B9c, on the other hand, is a membrane-permeable peptide that interferes with PSD-95/NMDAR binding. This interference leads to the decoupling of NR2B- and/or NR2A-type NMDARs from PSD-95[1][2]. | |||
TP1910 |
CALP1
|
||
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit | |||
T75791 |
CALP1 TFA
|
||
CALP1 TFA 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM),与 CaMEF-hand/Ca2+结合位点结合。CALP1 TFA 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50为 44.78 µM)。CALP1 TFA 阻止谷氨酸受体 (glutamate receptor channels) 通道,并阻止存储操作的非选择性阳离子通道。CALP1 TFA 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。 | |||
T75789 |
CALP3 TFA
|
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CALP3 TFA 是一种模拟 Ca2+ 的有效肽类 Ca2+ 通道阻断剂,能够激活 EF 手的 Ca2+ 结合蛋白。它通过影响钙调蛋白 (CaM)、Ca2+ 通道及泵的功能来模拟 [Ca2+]i 的增加,从而具备在控制 HIV 或缺血性神经元损伤等情况下调控细胞凋亡的能力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4558 |
Trioxsalen
三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen |
DNA Alkylator/Crosslinker; DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物,与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂,可用于激光激活定位的基因组链间交联可视化。 | |||
TN1131 |
Handelin
|
NF-κB; Immunology/Inflammation related | Immunology/Inflammation; NF-κB |
Handelin 是一种来自 Chrysanthemum boreale 的愈创木酚内酯二聚体,它能够阻碍 NF-κB 活化和促炎细胞因子产生,具有抗炎作用。 | |||
TN4272 | Isochandalone | Others | Others |
Isochandalone is a natural product from Derris robusta. | |||
TN4933 |
Sahandol
|
Antifection | Microbiology/Virology |
Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 |